Mean Corpuscular Hemoglobin Concentration

MCHC Mean corpuscular hemoglobin concentration OD Right eye (oculus dexter)... 

Gd gestational day (Gl) = gastric intubation (GO) = gavage in oil Hemato - hematological incr. = increased IPTPP = isopropyl triphenyl phosphate LD = lethal dose, 50% kill LOAEL = lowest-observed-adverse-effect level M = male MCV = mean corpuscular volume MCHC = mean corpuscular hemoglobin concentration mo = month(s) Musc/skel = musculoskeletal NOAEL = no-observed-adverse-effect level NS = not specified NTE = neurotoxic esterase RBC red blood cell Resp = respiratory TBEP = tributoxyethyl phosphate TBP = tributyl phosphate TMP = trimethyl phosphate TNBP = tri-n-butyl phosphate TOP = trioctyl phosphate wk = week(s) x = times yr = year(s). 

F, female M, male MCH, mean corpuscular hemoglobin MCHC, mean corpuscular hemoglobin concentration MCV, mean corpuscular volume RBC, red blood cell RDW, red blood cell distribution TIBC, total iron-binding capacity. 

Statistically significant decreases in hematocrit and increases in mean corpuscular hemoglobin concentration have been reported in men occupationally exposed to 0.46-0.75 ppm EGBE for 1-6 years." It was noted that changes were small, showed no relationship to exposure concentration, and were still within normal biological variability. 

Mean corpuscular hemoglobin concentrate (MCHC) 33-36 g/dL 20.3-22 mmol/L... 

Abdel-Rahman and coworkers (Abdel-Rahman et al. 1984b Couri and Abdel-Rahman 1980) also exposed male rats to sodium chlorite in the drinking water, 20 hours/day for up to 1 year, at concentrations that resulted in estimated doses of 1 or 10 mg/kg/day. Both dose levels resulted in increased mean corpuscular hemoglobin concentration (after 7, but not 9 months) and decreased osmotic fragility after 7-9 months). Erythrocyte glutathione levels were significantly decreased at dose levels 0.1 mg/kg/day by the end of the... 

Mean corpuscular volume Mean corpuscular hemoglobin Mean corpuscular hemoglobin concentration... 

In addition, quotients like Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Mean Corpuscular Volume (MC V) can be calculated. In case anaemia was induced by the testing material, its nature can be characterized macrocytic, microcytic, hypo- or hyper-chromic. The type of the anaemia provides information on the mechanism of induction of anaemia. 

Dawley) increased mean corpuscular hemoglobin concentration, 7% increased erythrocytes) ... 

Typical CBC results include severe anemia with the Hb concentration between 30 and 65g/L, MCV 48 to 72 L, and the mean corpuscular hemoglobin concentration (MCHC) 230 to 320 g/L. On the peripheral blood smear, a characteristic markedly abnormal RBC morphology is noted, which includes a large number of microcytes, numerous target... 

Rats were exposed for 4 weeks MCV, mean corpuscular volume MCH, mean corpuscular hemoglobin mass MCHC, mean corpuscular hemoglobin concentration values are mean of 10 animals/group < 0.05 p < 0.01 p < 0.001... 

Figure 3. Effect of iron intake on the mean corpuscular hemoglobin concentration (MCHC) in the rat. Diets contained either 10% (O) or 20% (A) protein (5).

Both the hematocrit values and the red cell counts (A) show much the same story. When these values were used to compute the mean corpuscular hemoglobin concentration (Figure 3) and the mean cell volumes (Figure 4) it was found that indeed a microcytic hypochromic anemia had been produced at the lowest iron intake levels.- However, the effect was much more pronounced when 20% protein was fed than when the diet contained 10% casein. 

Mean corpuscular hemoglobin concentration (MCHC) (BErc) ... 

When rats were exposed to 5, 25, or 77 ppm 2-butoxyethanol 5 days per week, 6 hours per day, for 13 weeks, decreased red blood cell count was observed at 77 ppm in males and females females also exhibited decreased hemoglobin and mean corpuscular hemoglobin concentration at 77 ppm (Dodd et al. 1983). Thus, 25 ppm is the NOAEL for hematological effects in rats after intermediate-duration inhalation exposure to 2-butoxyethanol. Based on this value, an intermediate inhalation MRL of 3.0 ppm for 2-butoxyethanol was calculated as described in the footnote to Table 2-1 and in Appendix A. 

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