Interferon murine

Dalod M, Hamilton T, Salomon R, et al. Dendritic cell responses to early murine cytomegalovirus infection subset functional specialization and differential regulation by interferon alpha/beta. J Exp Med 2003 197(7) 885-898. 

Segel MJ, Izbicki G, Cohen PY, et al. Role of interferon-gamma in the evolution of murine bleomycin lung fibrosis. Am J Physiol Lung Cell Mol Physiol... 

Polynucleotides. Polynucleotides are potent interferon inducers. A mismatched, double-stranded synthetic polyribonucleotide ampligen and the double-stranded acids, polyadenylic-polyuridylic acid and polyinosinic-polycytidylic acids have been widely studied for cancer therapy(ii). Although these materials elicit excellent activity with murine rodents, therapeutic effects are dramatically decreased within primates. 

Drapier,J.C., Wietzerbin, J. and Hibbs, J.B. Jr (1988) Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. European Journal of Immunology 18,1587-1592. 

Black, P.L. et al., Antitumor response to recombinant murine interferon gamma correlates with enhanced immune function of organ-associated, but not recirculating cytolytic T lymphocytes and macrophages, Cancer Immunol Immunother., 37, 299, 1993. 

HosakaY, Taguchi K, Iwamoto T, Kuroda K, Tsuruoka H, Xu H, Hamaoka T. Ultrastructure of murine tumour cell lines defective in MHC class I expression before and after interferon-y treatment. J Electron Microsc 1998 47 495-503. 

G-CSF expression is controlled at both the transcriptional and posttranscrip-tional levels. A sequence of 300 nucleotides upstream of the initiation codon is conserved in both the murine and human genes, and this appears to contain three regulatory sites. G-CSF (and some other cytokine genes) may be constitutively transcribed by cells such as blood monocytes, fibroblasts and endothelial cells, but the mRNA may be short-lived (fi/2 < 15 min). The mRNA contains poly-AUUUA sequences in the untranslated region, and this motif is usually associated with mRNA instability. Indeed, such regions have also been identified in mRNA for GM-CSF, IL-1, IL-6, interferons, TNF, some growth factors, c-jun, c-fos, c-myc and c-myb. Upon the addi-... 

Seymour BW. Gershwin LJ. Coffman RL Aerosol-induced immunoglobulin-E unresponsiveness to ovalbumin does not require CDS 4- or T-cell receptor-y/8-H T cells or interferon-y in a murine model of allergen sensitization. 1 Exp Med 1998 187 721-731. 

The specific regulatory role of HI documented for the Xenopus 5S RNA gene points to the importance of AT-rich tracts in the genome as potential sites of strong and preferential HI binding. Indeed, it has been shown that histone HI is probably involved in the repression of the murine /1-interferon promoter by binding to its upstream AT-rich region [143]. 

Effect of carcinogenic components of cigarette smoke on in vivo production of murine interferon. Cancer Res 1983 43(10) 4720-4722. 

Stuehr, D. J., and Marietta (1987). Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, t>r interferon-gamma. J. Immunol. 139, 518-525. 

Senda T, Shimazu T, Matsuda S, Kawano G, Shimizu H, Nakamura KT, Mitsui Y. Three-dimensional crystal structure of recombinant murine interferon-(3. EMBO J 1992 11 3193-3201. 

Zavodny PJ, Petro ME, Chiang TR, Narnia SK, Leibowitz PJ. Alterations of the amino terminus of murine interferon gamma expression and biological activity. J Interferon Res 1988 8 483-494. 

Spolski, R.J., Thomas, P.G., See, E.J., Mooney, K.A. and Kuhn, R.E. (2002b) Larval Taenia crassiceps secretes a protein with characteristics of murine interferon-"/. Parasitology Research 88, 431-438. 

D2. Dao, T., Ohashi, K., Kayano, T., Kurimoto, M., and Okamura, H., Interferon -inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper cells. Cell Immunol. 173, 230-235 (1996). 

These pure dextran phosphates exhibit immunostimulatory effects independent of the molecular weight. It was shown that the mitogenic response of murine splenocytes can be enhanced [101]. Moreover, dextran phosphate (Mw 40 000 g mol-1) increases the survival rate of mice infected with influenza A2 virus (H2N2). Intraperitoneal administration of dextran phosphate, an interferon inducer, shows a 1-day delay in the virus growth in lung, and production of HAI antibody, when compared to the non-treated or dextran-treated mice as controls. More significant was the 2-day delay in the development of lung consolidation, which led to 40% survival of the treated mice [102]. 

Rolls, J. K., Lei, D., Nelson, S., Summer, W. R. and Shellito, J. E. (1997). Pulmonary cytokine gene therapy. Adenoviral-mediated murine interferon gene transfer compartmentally activates alveolar macrophages and enhances bacterial clearance. Chest 111, 104S. 

Mice and humans (and their respective cytokines and receptors) have been evolutionarily separated for over 100 million years. Consequently, the murine interferons differ from all of the human interferons at fifty-six to seventy-two amino-acid positions. Nevertheless, it was possible, simply by recombining human sequences, to produce an interferon with an activity greater than that of the natural mouse protein. Sequences that had been pre-tested in humans to function as a-interferons contained the information necessary to build a protein that functions well with murine cells. Even though it was not possible to reconstruct the exact sequence of murine a-interferon from the human genes, it was possible to reconstruct its function. 

Blach-Olszewska, Z. and lanusz, M. 1997. Stimulatory effect of ovine colostrinine (a proline-rich polypeptide) on interferons and tumor necrosis factor production by murine resident peritoneal cells. Arch. Immunol. Ther. Exp. 45, 43-47. 

TerrellTG, Green JD. Comparative pathology of recombinant murine interferon-y in mice and recombinant human interferon-y in cynomolgus monkeys. Exp Pathol 1993 34B 73,101. 

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