Tumor weight, inhibition

Various lipid Tumor volume Inhibition Tumor weight Inhibition... 

Anionic polyelectrolytes have been shown to enhance resistance to bacteria and fungi, enhance immune response, inhibit adjuvent arthritis and either depress or stimulate phagocytic activity of the reticuloendothelial system [458,459]. Carboxylic acid polymers have shown interferon induction, antiviral activity, and tumor growth inhibition [460]. The effects include inhibition of sarcoma, leukemia, polyoma and vesicular stomatitis virus. In one application, the cytotoxicity of bleomycin toward cultured mammalian cells was synergisti-cally enhanced by stirring in the presence of high molecular weight polyfacrylic acid) [461]. 

Various lipid fractions Tumor volume mm3 Inhibition % Tumor weight mg Inhibition %... 

Various lipid fractions (800 mg/kg) were orally administered for 20 day in sarcoma 180-bearing mice. Inhibition ratio (%) was measured as tumor volume or tumor weight of various lipid fraction-treated mice/ tumor volume or tumor weights of control mice. Each value represents the means S.E. of 10 mice. P<0.05, Significantly different from sarcoma 180-bearing mice. 

Fig. 14.3. Treatment effect on tumor growth. (A) Treatment with IFL significantly (P= 0.0009, RM ANOVA) inhibited the growth of FIT-29LP tumors as measured by bioluminescence imaging. (B) Tumor weight measurements confirmed antitumor effects of IFL. Mean tumor weight in the IFL group was significantly (P< 0.0001, one-way ANOVA) lower...

In the initial study by Ip et al. (1991), the authors fed rats a standard diet or that diet supplemented with 0.5, 1.0 or 1.5% CLA, 2 weeks prior to and following administration of the carcinogen 7, 12-dimethylbenz[a]anthracene (DMBA). At the end of the experiment, the total number of mammary adenocarcinomas in the groups fed 0.5, 1.0 and 1.5% CLA was reduced by 32, 56 and 60% compared to the control, respectively. Tumor incidence, tumor multiplicity (number of tumors per rat) and total tumor weight were reduced to a similar degree. This tumor inhibition by CLA is in contrast to linoleic acid, which promotes tumor development in this model. 

In the mice with intrasplenicalty implanted LLC cells, the increase of tumor weight in the spleen was significantly inhibited by the oral administration of tuna triacylglycerols (1000 mg/kg) Fig. (5) . 

As shown in Table (16) , Fr. 1 and Fr. 2at a dose of 100 mg/kg, twice daily significantly inhibited tumor volume and tumor weight on day 15. Furthermore, the above two fractions inhibited metastasis to the lung and the increase of lung weight that occurred in tumor-removed mice Table (16) . 

As shown in Fig. (24) , 4-hydroxyderrcin (25 or 50 mg/kg, twice daily) significantly inhibited tumor growth on days 8 to 14. Tumor weight at day 15 was reduced by the twice-daily oral administration of 4-hydroxyderricin (25 or 50 mg/kg x 2/day) Fig. (25) . Furthermore, 4-hydroxyderrcin (25 or 50 mg/kg, twice daily) prolonged the survival time and survival rate compared to those in mice after the removal of tumors Fig. (26) . 

Key i.c., intracutaneous i.p., intraperitoneal i.v., intravenous. Lipopolysaccharide was injected either daily for seven days, or for three days on days 2, 4, and 6 after tumor inoculation. Mice used were dd/Y (inbred strain). Tumors were removed and weighed on the 14th day after implantation. Inhibition ratio (%) was calculated on the basis of the tumor weight given by the authors. 

Almeida et al. [6] thus tested a purified fraction from the rhizome of Wilbrandia sp. and demonstrated not only that the fraction inhibited KB cells with an effective concentration-50 (EC50) of 12 pg/ml, but also that it reduced the relative tumor weight of rats bearing Walker 256 carcinosarcoma by 65% [6,59]. These effects were thought to be due to the presence of cucurbitacins WGi and WG2 in the fraction, but the pure compounds were not tested. 

In %. Tumor inhibition ratio (C - T)/C x 100 (C - tumor weight of control mice, T tumor weight in lentinan treated mice. 

Fig. 3 His-TAT-HA-CARP-1 (1-198) protein inhibits growth of human breast cancer cell-derived tumor xenografts in SCID mice. The wild-type breast cancer cells were xenografted subcutaneously in each flank. After the palpable tumors developed, the proteins were injected intratumorally at a dose of 25 pg/tumor/day for 5 consecutive days and tumor growth monitored for additional 20 days. Histogram columns represent mean tumor weight and the standard deviation is indicated by bars. P = 0.0015 P = 0.003 compared with the corresponding His-TAT-HA-eGFP-treated tumors (adapted from Zhang et al. [251])...

Fig. 5 Tumor growth inhibition of s.c. human breast MCF-7 carcinoma xenografts in BALB/c nude mice. Mice were injected i.v. with 10 mg/kg DOX equivalent dose DOX-loaded PHSM ( ), PHSM/f (A), PHIM (V), PHIM/f (O), and DOX ( ). Two i.v. injections on days 0 and 3 were made, (a) Tumor volume change and (b) body weight change (n = 5). Values are the means of the standard deviations (SD) (adapted from Ref. [120] with permission)...

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