Tumor-inhibiting properties

Podophyllotoxin, a potentially lethal component of mayapple, blocks cell division and has tumor-inhibiting properties. Two drugs derived from it are approved for use in the U.S. Etoposide is used to treat testicular and small-cell lung cancer. Teniposide is employed with brain tumors and childhood leukemia (see Chapter 62). 

Kandioller W, Hartinger CG, Nazarov AA, Bartel C, Skocic M, Jakupec MA, Arion VB, Keppler BK (2009) Maltol-derived ruthenium-cymene complexes with tumor inhibiting properties the impact of ligand-metal bond stability on anticancer activity in vitro. Chem-EurJ 15 12283-12291... 

Schneider MR, Von Angerer E, Schonenberger H, Michel RT, Fortmeyer HP (1982) 1, 1, 2-triphenylbut-l-enes relationship between structure, estradiol receptor affinity, and mammary tumor inhibiting properties. J Med Chem 25 1070-1077... 

Tumor-inhibiting properties of (C5H5)2MCl2 in optimum doses against various experimental tumor systems... 

The constitutions of 6a,7-dehydroglaucine (26e) (191), hernandonine (35c) (432), imenine (35e) (433), oxonuciferine (35g), dicentrinone (35h), and lanuginosine (35b) have been elucidated (393, 434). The latter five oxo bases have not yet been found in the Papaveraceae. Because some of the oxo-aporphine alkaloids have cytotoxic (tumor inhibiting) properties, their further study could be fruitful (435). 

In addition to antimicrobial applications, p(l,3)-Glucans have been explored as antitumor agents for cancer therapeutics. It is believed that the activity of these polysaccharides is related to their triple helical conformation, as denaturation of the polysaccharide leads to the loss of tumor inhibition properties. However, the precise mechanism of any observed antitumor activity is poorly understood. These effects are... 

Thioguanine has multiple metabolic effects. Its tumor inhibitory properties may be due to one or more of its effects on feedback inhibition of de novo purine synthesis inhibition of purine nucleotide interconversions or incorporation into DNA and RNA. The net conseqnence of its actions is a sequential blockade of the synthesis and utilization of the purine nucleotides. 

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