Ascitic tumors, inhibition

Yarbro JW, Kennedy BJ, Barnum CP. Hydroxyurea inhibition of DNA synthesis in ascites tumor. Proc Natl Acad Sci USA 1965 53 1033-1035. 

Fetner has also demonstrated chromatid breaks in a human tissue-culture cell line exposed to ozone at 8 ppm for 5 min. Other tissue-culture studies include that of Sachsenmaier et who noted tetraploidy and other chromosomal abnormalities in embryonic chick fibroblasts exposed to ozone and a decrease in transplantability of mouse ascites tumor cells. In addition, Pace et demonstrated an interference by ozone with mitotic activity in two tissue-culture cell lines. More recently, Booher et al. reported that lung cells exposed in culture to ozone concentrations as low as 0.3 ppm demonstrated an inhibition in growth that was proportional to the ozone concentration. 

Gregory, R.I. et al. (2002) Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2afl-rsl locus in mouse embryonic stem cells. J. Biol. Chem. 277, 11728-11734. Thomas, G., Lange, H.W., and Hempel, K. (1975) Kinetics of histone methylation in vivo and its relation to the cell cycle in Ehrlich ascites tumor cells. Eur. J. Biochem. 51, 609-615. 

Genotoxic Effects. Genotoxic Effects. HDI was demonstrated to be non-mutagenic against some Salmonella typhimurium strains with or without metabolic activation (Anderson et al. 1980). HDI also inhibited the growth of Ehrlich ascites tumor eells in female mice (Moos et al. 1971) and decreased the mutation frequency in Escherichia coli (Kawazoe et al. 1981). Calf thymus DNA incubated in vitro with 10.4 or 52 mol of HDI for 10 or 20 minutes produeed no evidence of intrastrand cross-links or DNA strand breaks (Peel et al. 1997). No studies were located that studied the genotoxic effects of HDI on human cells or that deseribed the ability of prepolymer forms of HDI to induce genotoxicity."... 

Moos GE, Mcquire JA, Kitchlew WA, et al. 1971. Inhibition of growth of erhlich ascites tumors in ICR-Ha Swiss mice by isocyanates. Cancer Res 31 937-941. 

Berberine inhibits oxidative decarboxylation of yeast pyruvic acid (310) the same dose has, however, no effect upon aerobic glycolysis, Warburg s respiratory enzymes, indophenol oxidase, etc. Berberine and tetrahydroberberine have an inhibitory effect on oxidation of (+ )-alanine in rat kidney homogenates (498). Berberine and palmatine show a specific inhibitory effect upon cholinesterase in rabbit spleen and on pseudocholinesterase in horse serum (499). Berberine inhibits cellular respiration in ascitic tumors and even in tissue cultures (500-502). The specific toxic effect of berberine on the respiration of cells of ascitic tumors in mice was described (310). The glycolysis was not found to be affected, but the uptake of oxygen was smaller. Fluorescence was used in order to demonstrate berberine in cellular granules. Hirsch (503) assumed that respiration is inhibited by the effect of berberine on the yellow respiratory enzymes. Since the tumorous tissue contains a smaller number of yellow respiratory enzymes than normal tissue it is more readily affected by berberine. Subcutaneous injections of berberine, palmatine, or tetrahydropalmatine significantly reduce the content of ascorbic acid in the suprarenals, which is not affected by hypophysectomy (504). 

Considerable evidence has shown that selenium can inhibit the growth of experimentally transplanted tumors (65-74) One of the principal cell lines that has been used for many of these studies has been the Ehrlich ascites tumor cell (65-68) Abdullaev et al., (65) showed that the parenteral administration of sodium selenite at a dose of 1 ug per g body weight of the host retarded the growth of this tumor cell line. Additional studies also revealed that similar quantities of jelenium inhibited the growth of Guerin carcinoma, sarcomatous M neoplasms and L-1210 leukemic cells (65, 74) ... 

Sodium selenite and selenodiglutathione have been found to be more effective in inhibiting the growth of Ehrlich ascites tumors than sodium selenide, dimethyl selenide or seleno-DL-cystine. Preincubation of tumor cells with either 1 or 3 ppm Se as GSSeSG, Na SeO or dimethylselenide before reinoculated into mice resulted in a significant increase in survival in mice inoculated with cells pretreated with GSSeSG (69) (Table IV). Vernie et al.,... 

Partial inhibition of glycolysis by saturated fatty acids has been observed in Ehrlich ascites tumor cells. Palmitate and acetate decreased glutamate formation from glutamine (the first step in glutaminolysis) in this cell line, suggesting the possible role of fatty acids as an alternative energy source (Butler et al., 1999). 

Erythrocytes from humans, birds, and rat Ehrlich ascites tumor cells astrocytes fibroblasts C67 glioma cells intestine trachea parotid MDCK cells retinal pigment epithelium frog skin HeLa cells rabbit medullary thick ascending limb Inhibition of K+ and Cl channels... 

Pyrazinamide is one of the most powerful drugs available for the inhibition of urate excretion in man, consistently providing a 80-90% reduction in the renal clearance of uric acid (1401, 1403). 2-Morpholinocarbonylpyrazine and its 6-methoxy derivative are claimed to have antidiabetic activity (948, 949, 1351, 1387, 1404), and some 2-(p-ureidosulfonylphenethylcarbamoyl)pyrazines have been shown to have hypoglycemic activity in mice (1405). The effect of 2-amino-3-hydroxy-carbamoylpyrazine on DNA synthesis by Erlich ascites tumor cells in vitro has been investigated (1406) as well as the inhibition by 2-amino-3-hydroxycarbamoylpyrazine on L-histidine carboxylyase (1407) many 2-hydroxyimidazo[4,5-6]pyrazines (prepared from 2-amino-3-hydrazinocarbonylpyrazines with nitrous acid) are potent hypotensive agents in animals (880,891,963,1181). 

Polysaccharides may be active components in undefined aqueous extracts (from sonicated E. coli) which inhibited ascites tumors, such as Sarcoma 180, Ehrlich carcinoma, and MM2 in ddD mice.70 Likewise, polysaccharides may be implicated in the activity of heat-killed Corynebacterium parvum against tumors in mice.71-73... 

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