Induced skin tumor inhibition

Inhibition of A -nitrobis-(2-hydroxypropyl)amine (BHP) induced pancreatic tumors Inhibition of DMBA/TPA induced skin tumors Inhibition of DMBA/teleocidin B induced skin tumors Inhibition of DMBA/fumonsin-Bl induced skin tumors Inhibition ofNOR-l/TPA induced skin tumors Inhibition of DMBA/okadaic acid induced skin tumors Inhibition of DMBA/mineral oil induced skin tumors... 

Skin 1 Inhibition of 7,12-dimethylbenz[a Janthracene (DMBA 2)/TPA induced skin tumors (Topical application) [8,3739-42]... 

Skin 11 Inhibition of DMBA/TPA induced skin tumors (Oral application) [43]... 

Huang et al. [70] have evaluated the effects of chlorogenic acids on tumor promotion in an animal study using CD-I mice. Chlorogenic, caffeic and ferulic acids inhibit the induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate (TPA). TPA-mediated DNA synthesis has been weakly inhibited, but TPA-induced skin tumor promotion has been markedly inhibited by these compounds. 

Skin-2 Inhibition of DMBA/teleocidin B induced skin tumors... 

Gingerol, a prineipal pungent ingredient of ginger, strongly inhibited TPA-induced skin tumor promotion when topieally applied onto dorsal skin of female ICR mice... 

Powdered caraway inhibited lipid peroxidation in stored chicken meat. An ethanol extract of the seeds showed greater potency. As a supplement in the diet of mice, the oil inhibited carcinogen-induced skin tumors however, best results were found from topical application of the oil. Carvone and limonene have shown in vitro chemopreventive activity by... 

Female SKH-1 mice (7-8 weeks old) initiated with a single dose 200 nmol of DMBA and promoted with 30 mJ/cm UV twice a week for 34 weeks resulted in formation of an average 13.6 skin tumors per mouse and 100% of mice had skin tumors (Table V). Topical application of 10 pmol DBM at 10 min prior to each UV irradiation twice a week for 34 weeks decreased the number of skin tumors was to 1.2 tumors per mouse (91% inhibition). The percentage of mice with tumors was also reduced to 56% (44% inhibition). Topical plication of 10 pmol PABA at 10 min prior to each UV irradiation twice a week for 34 weeks inhibited the number of tumors per mouse by 79.7%, and the percentage of mice with tumors was inhibited by 14%. The results indicate that both DBM and ABA protect against UV-induced skin tumor promotion, and DBM has a better protection against UV-induced skin tumor promotion than PABA under these conditions. 

On the other hand, morusin (3) itself did not show a tumor promoting activity on mouse skin, x in Figs. (10) and (11). From these results, morusin (3) is an anti-tumor promoter judging from its ability to inhibit the short-term effects induced by tumor promoters. 

Mantena SK, Meeran SM, Elmets CA, Katiyar SK. 2005. Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors. J Nutr 135 2871-2877. 

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