Inhibition induced lung tumors

Poirier LA, Theiss JC, Arnold LJ, et al. 1984. Inhibition by magnesium and calcium acetates of lead subacetate and nickel acetate-induced lung tumors in strain A mice. Cancer Res 44 1520-1522. 

Lung Inhibition of 4-(methylnitrosoamino)-I-(3-pyridyI)-l-butanone (NNK) induced lung tumors [46]... 

Koizumi A, Tsukada M, Hirano S, Kamiyama S, Masuda H, Suzuki KT. Energy restriction that inhibits cellular proliferation by torpor can decrease susceptibility to spontaneous and asbestos-induced lung tumors in AJJ mice. Lab Invest 1993 68 728-739. 

Inhibition of azoxymethane (AOM) induced colon tumors Inhibition of Af-methyl-A -nitrosourea (NMU) induced colon tumors Inhibition ofiV-diethylnitrosamine (DEN)/phenobarbital (PB) induced hepatic tumors Inhibition of sponateneous hepatoma development in C3H/HeNCrj mice Inhibition of 4-(methylnitrosoamino)-l-(3-pyridyl)-I-butanone (NNK) induced lung tumors Inhibition of 4-nitroquinoline-W-oxide (4-NQO)/glycerol induced pulmonaiy tumors Inhibition of NMU induced mammary tumors... 

Inhibition of 4-(methylnitrosaniino)-l-(3-pjridjl)-l-butanone-induced lung tumors... 

The effect of BHA on the In vivo formation of BP metabolite-DNA adducts in the forestomach of female A/HeJ mice was also examined (7) In this study, mice were fed BHA, 0.5% of diet, for eighteen days. H-BP mg/mouse) was adminitered and the animals were sacrificed 48 hours later. As in lung and liver, the BPDEI-deoxyguanosine adduct was the predominant adduct formed in the forestomach. BHA treatment inhibited the formation of BPDE-DNA adducts in the forestomach by 50%. Wattenberg (8) has shown that BHA treatment inhibits BP-induced forestomach tumors approximately 90%. Although our protocol for administration of BP was not identical to that used in the tumorigenicity studies, we can still see a definite trend between BHA inhibition of BPDE-DNA adduct formation in the forestomach of A/HeJ mice and reduction in tumor formation. 

Lung-2 Inhibition of 4-nitroquinoline-/V-oxide (4-NQO)/glycerol induced pulmonaty tumors... 

Shi J, Zheng D, Liu Y, Sham MH, Tam P, Farzaneh F, Xu R. Overexpression of soluble TRAIL induces apoptosis in human lung adenocarcinoma and inhibits growth of tumor xenografts in nude mice. Cancer Res 2005 65 1687-1692. 

Dietary pretreatment with DDT decreased the incidence of mammary tumors induced by dimethyl benzanthracene (21). Carcinogenicity of ethylene dibromide has been shown (18) to be increased by exposure to disulfiram. Induction of lung benzo(a)pyrene hydroxylase by carbaryl paralleled an Increase in lung tumors induced by benzo(a)pyrene (19). In the same experiments, pretreatment with toxaphene decreased the incidence of lung adenomas (19) and this correlated with the inhibition of lung benzo(a)pyrene hydroxylase. 

Malkinson, A.M. et al.. Inhibition of 4-(methylnitrosammo)-l-(3-pyridyl)-l-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone). Carcinogenesis, 19, 1353, 1998. 

Yang, G., Wang, Z.Y., Kim, S., Liao, J., Seril, D.N., Chen, X., Smith, T.J., and Yang, C.S., Characterization of early pulmonary hyperprohferation and tumor progression and their inhibition by black tea in a 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone-induced lung tumorigenesis model with A/J mice. Cancer Res. 57,1889-1894,1997. 

Inhibition of Benzo[a]pyrene-induced forestomach and lung tumors... 

Table 3. Inhibition of BP-Induced Forestomach and Lung Tumors in A/J Mice by BT and HF...

Beef, effect of analysis on sulfur-containing flavor compounds, 49-60 Benzo[a]pyrene-induced forestomach and lung tumors, inhibition by 2- -butylthiophene and 2-iV-heptylfuran, 283,2851 Brassica, source of goitrogens, 106 Brassica oilseeds alternative methods of processing, 113,116... 

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