Tumor inoculation, inhibition

In AKR mice treated (daily x 8) 8 days posttumor inoculation. Key -, 0-25% tumor growth inhibition +, 26-50% tumor growth inhibition + +, 51-75% tumor growth inhibition + -I- +, 76-100%, tumor growth inhibition T, toxic in 50% of treated animals. 

Key i.c., intracutaneous i.p., intraperitoneal i.v., intravenous. Lipopolysaccharide was injected either daily for seven days, or for three days on days 2, 4, and 6 after tumor inoculation. Mice used were dd/Y (inbred strain). Tumors were removed and weighed on the 14th day after implantation. Inhibition ratio (%) was calculated on the basis of the tumor weight given by the authors. 

The follicles are used to treat asthma and cough and to mitigate painful swollen breasts. A paste of the leave is applied to contusion. Essential oil distilled from the follicles induced apoptotic death in HepG2 human hepatoma cells in a concentration- and time-related manner, and inhibited tumor development of mice inoculated with Huh-7 human hepatoma cells (33). 

Sodium selenite and selenodiglutathione have been found to be more effective in inhibiting the growth of Ehrlich ascites tumors than sodium selenide, dimethyl selenide or seleno-DL-cystine. Preincubation of tumor cells with either 1 or 3 ppm Se as GSSeSG, Na SeO or dimethylselenide before reinoculated into mice resulted in a significant increase in survival in mice inoculated with cells pretreated with GSSeSG (69) (Table IV). Vernie et al.,... 

Fig. 3.6 Nanoparticle siRNA delivery for tumor treatment, a N2Atumor-beaiing mice received a single intravenous injection of 40 mg pLuc in RPP-nanoplexes only, with control siRNA or with Luc-specific siRNA. 24 h following administration, tissues were assayed for luciferase activity (n = 5). b Mice were inoculated withN2Atumor cells and left untreated (open squares) or treated every 3 days by tail vein injection with RPP-nanoplexes with control siRNA or VEGF R2-spedflc siRNA at a dose of 40 mg per mouse. Treatment was started when the tumors became palpable (>20mm ). Only VEGF R2-sequence-speciflc siRNA inhibited tumor growth, whereas treatment with control siRNA did not affect tumor growth rate when compared with untreated controls n = 5)...

DF, mice were inoculated with 10 Lewis lung cells into right-hind gluteus muscle. Polymers were administered daily by the intraperitoneal route for 10 consecutive days following tumor implantation. Primary tumor size was determined on day lU (55 inhibition) and increased life span (55 ILS) calculated from mean time to death. 

Animals treated i.p. with pyran produced a 30 fold inhibition of Ehrlich ascites tumor growth with maximum inhibition of tumor growth occurlng with pyran treatment two days prior to tumor cell inoculation (Table XIII) (60. ... 

Table XIII. Inhibition of Ehrlich Ascites Tumor Cell Prolifera-tion in vivo by Eyran Inoculation...

---