Tumor angiogenesis, inhibition

These novel tetrameric bromotyrosine metabolites display a range of biological activities, including effects on calcium channels (1900), lipoxygenase inhibition (1772), tumor angiogenesis inhibition (1901), and endothelial cell anti-proliferation (1902). Syntheses of several bastadins have been accomplished (1903,1904). 

Peterson, H.-I. (1986) Tumor angiogenesis inhibition by prostaglandin synthetase inhibitors. Anticancer Res. 6,251-254. 

Pleiotrophin Growth factor Inhibition of colony formation decrease of in vivo tumor growth, tumor angiogenesis, and metastatic ability... 

ZHOU J R, GUGGER E T, TANAKA T, GUO Y BLACKBURN G L and CLINTON S K (1999) Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J Nutr. 129 (9) 1628-35. 

Folkman J, Langer R, Linhardt RJ, Haudenschild C, Taylor S (1983) Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone. Science 221 719-725. 

Torisel ) antibiotic NP arrest in ttie G1 phase, and inhibits tumor angiogenesis by reducing synthesis of vascular endothelial growth factor (VEGF) ... 

Vajkoczy P, Menger MD, Goldbrunner R et al (2000) Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC. Int J Cancer 87 261-268... 

Prewett M, Huber J, Li Y, et al. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res 1999 59(20) 5209-5218. 

Huang SM, Harari PM. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin Cancer Res 2000 6 2166-2174. 

Another effect of LPS may be the inhibition of tumor angiogenesis. This was evidenced in melanoma B16- bearing C57BL/6 mice treated i.v. with the lipid A GL-60, after an IFN-y injection [114], It was confirmed in the same model using DT-5461 alone injected i.v. [94]. This effect of LPS is likely to be due to the production of TNF-a. This cytokine may be toxic for the endothelium [64], inhibiting at the same time the motility and proliferation of endothelial cells [59]. Sato et al. [115] showed that TNF-a inhibits tumor-induced angiogenesis in a rabbit corneal pocket assay. On the contrary, Vukanovic and Isaacs [116] concluded that TNF-... 

Aoki S, Cho S, Ono M, Kuwano T, Nakao S, Kuwano M, Nakagawa S, Gao J-Q, MayumiT, Shibuya M, Kobayashi M (2006) Bastadin 6, a Spongean Brominated Tyrosine Derivative, Inhibits Tumor Angiogenesis by Inducing Selective Apoptosis to Endothelial Cells. Anti-Cancer Drugs 17 269... 

Luttun A, Tjwa M, Moons L, et al. Revascularization of ischemic tissues by PIGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-FIt I. Nat Med 2002 8 831-840. 

Corada, M., Zanetta, L., Orsenigo, F., Breviario, F., Lampugnani, M. G., et al. 2002. A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability. Blood 100 905-911. 

The n-6 PUFAs have been shown to upregulate COX-2 expression,80 whereas n-3 PUFAs have been shown to suppress its expression in tumors,81,82 in association with decreased proliferation of cancer cells and reduced tumor angiogenesis.83 n-3 PUFAs have also been shown to suppress tumor growth via a COX-independent pathway.84 DHA, in comparison with LA, has also been shown to decrease the expression of other oncogenes implicated in tumor promotion including ras85 and bcl-2 expression,86 resulting in inhibition of mitosis and enhanced apoptosis of cancer cells, respectively. 

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