Human colon adenocarcinoma cell line

PALOZZA P, SERINI S, MAGGIANO N, ANGELINI M, BONINSEGNA A, DI NICUOLO F, RANELLETTI F O and CALVIELLO G (2002) Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by P-carotene through down-regulation of cyclin A and Bcl-2 family proteins , Carcinogenesis, 23, 11-18. 

FIGURE 1.2 2D liquid protein expression map of the HCT-116 human colon adenocarcinoma cell line. (See text for full caption.)... 

Human colon adenocarcinoma cell line used as an absorption model... 

Peters, W. H. N., Roelofs, H. M. J., Time-dependent activity and expression of glutathione S-transferases in the human colon adenocarcinoma cell line Caco-1, Biochem. J. 1989, 264, 613-616. 

The human colon adenocarcinoma cell line (Caco-2) assay is still commonly used to measure the potential for a compound to be absorbed. It measures the permeability potential because permeability is a component of the absorption process,3 27 31 Multiple reports discuss the use of HPLC/MS/MS to support the Caco-2 assay.32 38... 

Pinto, M., Robine-Leon, S., Appay, M.D., Kedinger, M., Triadou, N., Dussaulx, E., Lacroix, B., Simon-Assmann, P., Haffen, K., Fogh, and Zweibaum, A., Enterocytic-like differentiation and polarization of the human colon adenocarcinoma cell line Caco-2 in culture, Biol. Cell, 47,... 

Caco-2 cells and isolated small intestine are models of basic nutrition that contributed to the understanding of resveratrol absorption and bioavailability. While the Caco-2 absorption model is a well-defined cellular in vitro system based on a human colonic adenocarcinoma cell line, the isolated small intestine model is nearer to in vivo conditions and is also simpler to handle. It also avoids the methodological problems of in vivo perfusion models [Barthe et al., 1998, 1999]. 

Fujianmycins A and B were isolated from a Streptomyces species (IA-CAS-114) in Fujian, China [167], The structure of fujianmycin A (34a) may be regarded as the 2,3-hydrated form of (33a), and fujianmycin B (34b) as its methyl ether derivative. The structure of antibiotic PD-116740 (35), isolated from an unidentified actinomycete species (WP-4669) and possessing activity against L1210 leukaemia in vitro and HCT-8 human colon adenocarcinoma cell line [168], may be visualized as the 3-hydroxylated 8-methyl-5,6-diol derivative of (33a). All these antibiotics contain the characteristic 2-phenylnaphthalene structural feature. 

Harper PA, Prokipcak RD, Bush LE, et al. 1991. Detection and characterization of the Ah receptor in the human colon adenocarcinoma cell line LS 180. Arch Biochem Biophys 290 27-36. 

Fantini, J., Galons, J.-P., Marvaldi, J., Cozzone, P.J., Canioni, P. (1987). Growth of a human colonic adenocarcinoma cell line (HT 29) on microcarrier beads Metabolic studies by 31phosphorus nuclear magnetic resonance spectroscopy. Int. J. Cancer 39,225-260. 

P388/DX Lymphocytic leukemia cell line resistant to doxorubicin LoVo Human colon adenocarcinoma cell line... 

Human colonic adenocarcinoma cell line Caco-2 Downregulating cyclin D1/Cdk4 complex and upregulating cyclin E and A expression [125]... 

The introduction of new technologies in recent years is increasing the throughput of ADME studies during the drug discovery process. The advent of cell culture techniques in recent years has facilitated the assessment of intestinal permeability for many drugs. A notable example is the use of CaCO-2 cells, an immortalized human colon adenocarcinoma cell line... 

In another study, the EO of the leaves of the Euphorbiaceae Croton flavens L. (yellow balsam) from Guadeloupe, a native plant from the Caribbean area, was analyzed by Sylvestre et al. (2006) and as main components viridiflorene (12.2%), germacrone (5.3%), (E )-Y-bisabolene (5.3%), and P-caryophyllene (4.9%) ascertained. The EO was found to be active against human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line DLD-1. Three of the 47 components of the EO, namely a-cadinol, P-elemene, and a-humulene, showed also a cytotoxic activity against tumor cell lines. Yu et al. (2007) tested the EO of the rhizome of the Aristolochiaceae Aristolochia mollissima for its cytotoxicity on four human cancer cell lines (ACHN, Bel-7402, Hep G2, HeLa). The rhizome oil possessed a significantly greater cytotoxic effect on these cell lines than the oil from the aerial plant. 

Pawlikowska-Pawlega B, Jakubowicz-Gil J, Rzymowska J, Gawron A. The effect of quercetin on apoptosis and necrosis induction in human colon adenocarcinoma cell line LS180. Folia Histochem Cytobiol 2002 39 217-218. 

Raubenheimer reported the anti-cancer activity of compound 34 (Figure 4.9).This complex was tested on human cervical epithelioid carcinoma cell line HeLa, human colon adenocarcinoma cell line CoLo 320 DM, leukaemia cell line Jurkat, and breast cancer cell line MCF-7. IC50 values determined by the MTT assay showed human lymphocytes were less sensitive than the cancer cells tested, indicating some selectivity for the cancer cells. 

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