Aristolochia mollissima

In another study, the EO of the leaves of the Euphorbiaceae Croton flavens L. (yellow balsam) from Guadeloupe, a native plant from the Caribbean area, was analyzed by Sylvestre et al. (2006) and as main components viridiflorene (12.2%), germacrone (5.3%), (E )-Y-bisabolene (5.3%), and P-caryophyllene (4.9%) ascertained. The EO was found to be active against human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line DLD-1. Three of the 47 components of the EO, namely a-cadinol, P-elemene, and a-humulene, showed also a cytotoxic activity against tumor cell lines. Yu et al. (2007) tested the EO of the rhizome of the Aristolochiaceae Aristolochia mollissima for its cytotoxicity on four human cancer cell lines (ACHN, Bel-7402, Hep G2, HeLa). The rhizome oil possessed a significantly greater cytotoxic effect on these cell lines than the oil from the aerial plant. 

Table 6 shows the eleven sesquiterpene esters of aristolochic acids isolated from Aristolochia species. Isolation of the aristoloterpenate I (40) from the radix of A. mollissima is the first report of such compounds in... 

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