Hippocampal

LTP) in hippocampal slices (89,90). LTP is believed to be a critical step in memory acquisition, and agents that possess the abiUty to augment this process in vivo are expected to be of benefit in memory enhancement. However, this compound has only demonstrated this property in vitro. In addition, because (11) does not appear to affect other neurotransmitter systems, as do other nootropics, the potential of BMY 21502 as a memory-enhancing agent is questionable. [Pg.96]

Crestani F, Keist R, Fritschy J-M et al (2002) Trace fear conditioning involves hippocampal a5 GABAa receptors. Proc Natl Acad Sci USA 13 8980—8985... [Pg.254]

Traumatic brain injury is the most common cause of death in subjects under the age of 40, and an important risk factor for AD. Loss of hippocampal cells and depletion of ACh and of muscarinic receptors can be attenuated in injured experimental animals, improve blood perfusion in ischemic areas and increase cholinergic transmission in cortex and hippocampus the same mechanism invoked for treatment of VD. [Pg.360]

Membrez M, Hummler E, Beermann F et al (2006) GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function. Mol Cell Biol 26 4268 876... [Pg.551]

The hippocampus, which got its name from the Greek word for seahorse, due to its form, is a nucleus in the depth of the temporal lobe. The hippocampus is important for the integration of sensory information, for spatial orientation and for memory formation. The hippocampal formation contains the CA (cornu ammonis) regions, the dentate gyms and the subiculum. [Pg.587]

More recent analysis of tissue specific gene deletions showed that the Cav1.2 channel is involved in a wide variety of function including hippocampal learning, insulin secretion, intestine and bladder motility. Further analysis will be required to unravel the functional significance of voltage-dependent calcium channels for specific cellular functions. [Pg.1304]

Carta M, Ariwodola OJ, Weiner J L, et al Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons. Proc Natl Acad Sci U SA 100 6813-6818, 2003... [Pg.43]

Van Sickle BJ, Tietz El Selective enhancement of AMPA receptor-mediated function in hippocampal CAl nemons from chronic benzodiazepine-treated rats. Nemo-pharmacology 43 11—27, 2002... [Pg.161]

Ikeuchi Y, Hirai H, Okada Y, et al Excitatory and inhibitory effects of toluene on neural activity in guinea pig hippocampal slices. Neurosci Lett 138 63—66, 1993... [Pg.308]

Mcnncrick S, Jevtovic-Todorovic V, Todorovic SM, ct al Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures. J Neuro-... [Pg.310]

Semino CE, Kasahara J, Hayashi Y et al (2004) Entrapment of migrating hippocampal neural cells in three-dimensional peptide nanofiber scaffold. Tissue Eng 10 643-655... [Pg.164]

Kruman 11, Nath A, Mattson MP (1998) HlV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp Neurol 154(2) 276-288... [Pg.26]

Meucci O, Fatatis A, Simen AA, BusheU TJ, Gray PW, MUler RJ (1998) Chemokines regulate hippocampal neuronal signaling and gpl20 neurotoxicity. Proc Natl Acad Sci USA 95(24) 14500-14505... [Pg.28]

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