Hippocampal LTP

Patterson, S. L., Abel, T., Deuel, T. A. et al. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16 1137-1145,1996. 

Initial evidence linking Hebb s coincidence detection rule to learning and memory. As the unique receptor in the brain with the coincidence-detection property, the NMDA receptor is an ideal candidate to gate the formation of memory at the synaptic level. Early observations demonstrated that infusion of NMDA receptor blockers into brain ventricles resulted in animals poor performance in the hidden-platform water maze. At first, this seemed to provide evidence for the role of hippocampal LTP in memory formation. Unfortunately, careful analyses revealed that poor performances in the water maze tests... 

It is not established if these effects of glucocorticoid modulation are due to alterations to hippocampal LTP Hippocampal synaptic plasticity can be upregulated or downregulated depending on the levels of stress hormone... 

Gerlai R (2002) Hippocampal LTP and memory in mouse strains is there evidence for a causal relationship Hippocampus 12 657-666 Geschwind DH (2000) Mice, microarrays, and the genetic diversity of the brain. Proc Nad Acad Sci U S A 97 10676-10678... 

Morris RG (1996) Further studies of the role of hippocampal synaptic plasticity in spatial learning is hippocampal LTP a mechanism for automatically recording attended experience J Physiol Paris 90 333-334... 

Sakimura, K., Kutsuwada, T., Ito, I., Manabe, T., Takayama, C., Kushiya, E., Yagi, T., Aizawa, S., Inoue, Y., Sugiyama, H., Mishina, M. Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor s2 subunit, Nature 1995, 373, 151-155. 

Endocannabinoids have also been suggested to participate in long-term synaptic potentiation (LTP), a widely recognized model of synaptic changes underlying learning and memory (Malenka and Bear 2004). Prior to discovery of the CB1 receptor, one study indicated that A9-THC alters hippocampal LTP (Nowicky et al. 1987). Activation of CB1 receptors by 2-AG was shown to prevent LTP induction at Schaffer collateral-CAl pyramidal cell synapses in hippocampus (Stella et al. 

Fukazawa Y, Saitoh Y, Ozawa F, Ohta Y, Mizuno K, Inokuchi K (2003) Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. Neuron 38 447-60... 

Vaillend C, Billard J-M, Laroche S. 2004. Impaired long-term spatial and recognition memory and enhanced CA1 hippocampal LTP in the dystrophin-deficient Dmd (mdx) mouse. Neurobiol Dis 17 10-20. 

Larkman AU, Jack JJ (1995) Synapdc plasdeity Hippocampal LTP. Cult Opin Neui obiol 5 324—334. 

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