Chemokine regulation

Meucci O, Fatatis A, Simen AA, BusheU TJ, Gray PW, MUler RJ (1998) Chemokines regulate hippocampal neuronal signaling and gpl20 neurotoxicity. Proc Natl Acad Sci USA 95(24) 14500-14505... 

Belmadani A, Tran PB, Ren D, Miller RJ (2006) Chemokines regulate the migration of neural progenitors to sites of neuroinflammation. J Neurosci 26 3182-3191 Bensinger SJ, Tontonoz P (2008) Integration of metabolism and inflammation by lipid activated nuclear receptors. Nature 454 470-477... 

Nanki T, Nagasaka K, Hayashida K, Saita Y, Miyasaka N. Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Immunol 2001 167(9) 5381—5385. 

Kasama T, Stricter RM, Lukacs NW, Lincoln PM, Burdick MD, Kunkel SL. Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Invest 1995 95(6) 2868-2876. 

Takeuchi, H., A. Fujimoto, M. Tanaka, T. Yamano, E. Hsueh, and D. S. Hoon. 2004. CCL21 chemokine regulates chemokine receptor CCR7 bearing malignant melanoma cells. Clin Cancer Res 10 2351-2358. 

Luboshits, G., S. Shina, O. Kaplan, S. Engelberg, D. Nass, B. Lifshitz-Mercer, S. Chaitchik, I. Keydar, and A. Ben-Baruch. 1999. Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma. Cancer Res 59 4681. 

Zhao Q, Simpson LG, Driscoll KE, Leikauf GD. Chemokine regulation of ozone-induced neutrophil and monocyte inflammation. Am J Physiol 1998 274 L39-46. 

VI. Evidence That Chemokines Regulate the Pattern of Organ-Specific Metastasis... 

Chemokines regulate the migration of cells in vivo and dysregulated expression of chemokines and their receptors are implicated in autoimmune and inflammatory diseases. Inflammatory arthritides, such as rheumatoid arthritis (RA), are characterized by the recruitment of inflammatory cells into joints. The K/BxN serum transfer mouse model of inflammatory arthritis shares many similar features with RA. In this autoantibody-induced model of arthritis, neutrophils are the critical immune cells necessary for the development of joint inflammation and damage. In this review, we describe the use of several methods to study the role of chemoattractant receptors, including chemokine receptors, on the recruitment of neutrophils into the joint in the K/BxN model of inflammatory arthritis. This includes both traditional methods, such as flow cytometry, immunohistochemistry, and enzyme assays, as well as multiphoton in vivo microscopy that we have adapted to study the role of immune cell trafficking in and around the joint in live mice. 

Goger, B., Halden, Y., Rek, A., Mosl, R., Pye, D., Gallagher, J., etal. (2002). Different affinities of glycosaminoglycan oHgosaccharides for monomeric and dimeric interleukin-8 A model for chemokine regulation at inflammatory sites. Biochemistry, 41, 1640—1646. 

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