Between mGlul Receptors and Endocannabinoids in the CA1 Hippocampal Region

Interactions Between mGlul Receptors and Endocannabinoids in the CA1 Hippocampal Region 

Postsynaptic mGluI Receptors may Indirectly Inhibit the Release 

CB1 receptor antagonists are able to prevent this effect (Neu et al., 2007 Ohno-Shosaku et al, 2002). Similarly, a group I mGlu receptor-mediated retrograde inhibition of GABA release through endocannabinoids has been described in CA1 for both short-(Varma et al., 2001) and long-term (Chevaleyre and Castillo, 2003) forms of synaptic plasticity, as well as for the persistent effects of experimental febrile seizures on the enhancement of hippocampal excitability (Chen et al., 2007). 

CA1 pyramidal cell GABAa CA1 pyramidal cell GABAa 

Further studies are required to determine the validity of these hypotheses. The clarification of these mechanisms is expected to provide new insight into the possible targets for new therapeutic interventions for stroke and other ischemia-related syndromes. 

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