Hippocampal formation human

Halgren, E. Walter, R. D., Cherlow A. G. and Crandall, P. H. Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdale. Brain 101 83-117,1978. 

The anatomical visualization of 5-ht1E receptor mRNA has been done in monkey and human brain by in situ hybridization histochemistry (75) see also Fig. 4) and in the guinea pig brain (Fig. 4). The strongest signals are seen in the caudate and putamen, islands of Calleja, external and internal cortical layers (layers II and V in the monkey brain), CA fields and dentate gyms of the hippocampal formation, dorsal and ventral parts of the lateral septal nuclei, and some hypothalamic nuclei. 

Crook JM, Tomaskovic-Crook E, Copolov DL, Dean B. 2000. Decreased muscarinic receptor binding in subjects with schizophrenia A study of the human hippocampal formation. Biol Psychiatry 48 381-388. 

Dysbindin-1 gene expression in the human hippocampal formation shown seen with in situ hybridization. As seen at low magnification in (a), all major cell layers express the gene, but the level of expression is highest in the pyramidal layer of CA3 (c) and the polymorph layer of the DGh (d). Labeling with the antisense probe versus the sense probe is shown in (e) and (f), respectively. The scale bar in (a) is 1 mm, while those in (b-f) are 20 p.m. Reprinted with permission from Talbot et al. (2004)... 

The —33 kDa band (32-34 kDa) is close in molecular mass to dysbindin-1C, which lacks the NTR of dysbindin-1 A but is otherwise identical to dysbindin-1 A (see Section 2.2.2.2.1). It is consequently difficult to determine if the —33 kDa band represents (1) dysbindin-lC itself, (2) a degradative product of dysbindin-1 A missing the NTR, or (c) some combination of the first two possibilities. The first possibility seems most likely, however, because the —33 kDa band is absent in some tissues (e.g., cerebellum, kidney, and liver) where the —50 kDa band (i.e., dysbindin-1 A) is present and hence subject to degradation ( Figure 2.2-12c). Moreover, the —33 kDa band is often stronger than the 50 kDa band even in fresh tissue. We thus believe that the —33 kDa band does represent dysbindin-1C. It is seen in the heart, lung, skeletal muscle, striatum, hippocampal formation, and cerebral cortex (e.g., O Figure 2.2-12a and c). In synaptosomes of the mouse and human brain, the —33 kDa isoform is concentrated in synaptic vesicle and PSD fractions with very little, if any, present in the presynaptic membrane fraction (Talbot et al., in preparation). 

As noted earlier (see O Section 2.2.63.i), dysbindin-lB in human synapses is almost exclusively associated with synaptic vesicles. Consequently, our recent finding that dysbindin-lB is reduced in the hippocampal formation of schizophrenia cases confirms our previous quantitative immunohistochemi-cal finding that reduced dysbindin-1 occurs in glutamatergic presynaptic fields of associational and... 

Seress L, Gulyas Al, Ferrer I, Tunon T, Soriano E, et al. 1993. Distribution, morphological features, and synaptic connections of parvalbumin- and calbindin D28k-immunoreactive neurons in the human hippocampal formation. J Comp Neurol 337 208-230. 

Gurevich EV, Kordower JH, Joyce JN (2000) Ontogeny of the dopamine D2 receptor mRNA expressing cells in the human hippocampal formation and temporal neocortex. J Chem Neuroanat 20 307-325. 

Whitaker WR, Clare JJ, Powell AJ, Chen YH, Faull RL, Emson PC 2000 Distribution of voltage-gated sodium channel alpha-subunit and beta-subunit mRNAs in human hippocampal formation, cortex, and cerebellum. J Comp Neurol 422 123-139... 

Amaral, D.G. Insausti, T. (1990) Hippocampal formation. In The Human Nervous System (ed. Paxinos, G.), pp. 711—755. London, Academic Press. 

Hyman, B.T.,Elvhage, T.E. and Reiter, . 1994. Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer s disease. Am. J. Pathol. 144 565-572... 

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