Hippocampal formation monkey

Fig. 31 Staining for BrdU in IT of short-term (A) and long-term (B) monkey groups. Note the increase of positive cells after ischemia. The position of the visual field within the temporal lobe is schematically depicted as a frame in the map (upper right). STG> MTG, and ITG, superior, middle and inferior temporal gyrus PHG, parahippocampal gyrus HPC, hippocampal formation. Scale bar = 500 pm...

The anatomical visualization of 5-ht1E receptor mRNA has been done in monkey and human brain by in situ hybridization histochemistry (75) see also Fig. 4) and in the guinea pig brain (Fig. 4). The strongest signals are seen in the caudate and putamen, islands of Calleja, external and internal cortical layers (layers II and V in the monkey brain), CA fields and dentate gyms of the hippocampal formation, dorsal and ventral parts of the lateral septal nuclei, and some hypothalamic nuclei. 

Front cover Autoradiography showing the distribution of Y1-binding sites (top) and Y2-binding sites (bottom) at the level of the hippocampal formation of the monkey brain (see Dumont el al., Chapter 4). 

The dorsal and ventral hippocampus is involved in the formation of social memory (van Wimersma Greidanus and Maigret, 1996). Neonatal ablations of hippocampal regions can lead to decreased and abnormal social behavior in rhesus monkeys that is reminiscent of severe neuropsychiatric disorders in humans such as autism and schizophrenia (Bachevalier et ah, 1999). These monkeys are often withdrawn socially and will develop locomotoric stereotypies a pattern similar to that found in autistic children. 

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