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HAZARD-BASED RISK ASSESSMENTS

A large number of research and review papers have been published in recent years on the integration of data on physicochemical properties, in vitro derived toxicity data, and physiologically based kinetics and dynamics as a modeling tool in hazard and risk assessment [72-85]. [Pg.93]

The need to develop and use chiral chromatographic techniques to resolve racemates in pesticide residues will be driven by new hazard and risk assessments undertaken using data from differential metabolism studies. The molecular structures of many pesticides incorporate chiral centers and, in some cases, the activity differs between enantiomers. Consequently, in recent years manufacturers have introduced resolved enantiomers to provide pesticides of higher activity per unit mass applied. For example, the fungicide metalaxyl is a racemic mix of R- and 5-enantiomers, both having the same mode of action but differing considerably in effectiveness. The -enantiomer is the most effective and is marketed as a separate product metalaxyl-M. In future, it will not be satisfactory to rely on hazard/risk assessments based on data from metabolism studies of racemic mixes. The metabolism studies will need to be undertaken on one, or more, of the resolved enantiomers. [Pg.748]

As mentioned previously, the assessment of hazard and risk to humans from exposure to chemical substances is generally based on the extrapolation from data obtained in smdies with experimental animals. In the absence of comparative data in humans, a basic assumption for toxicological risk assessment is that effects observed in laboratory animals are relevant for humans, i.e., would also be expressed in humans. In assessing the risk to humans, an assessment factor is applied to take account of uncertainties in the differences in sensitivity to the test substance between the species, i.e., to account for interspecies variability (Section 5.3). If data are available from more than one species or strain, the hazard and risk assessment is generally based on the most susceptible of these except where data strongly indicate that a particular species is more similar to man than the others with respect to toxicokinetics and/or toxicodynamics. Two main aspects of toxicity, toxicokinetics and toxicodynamics, account for the namre and extent of differences between species in their sensitivity to xenobiotics this is addressed in detail in Chapter 5. [Pg.94]

In the following, several terms used to describe interactions between chemicals are mentioned as well as basic concepts used in the hazard and risk assessment of chemical mixmres. The description of these basic concepts, first outlined by Bliss (1939) and Placket and Hewlett (1952), are based on the publications by Konemann and Pieters (1996), Cassee et al. (1998), and Groten et al. (2001). The definitions of additivity, synergism, antagonism, and potentiation are those of Klaassen (1995) and Seed et al. (1995). [Pg.373]

To validate the predicted risk, the actual impact of dumped harbour sediments on local ecosystems can be determined using a dedicated set of in vitro and in vivo bioassays as well as bioindicators selected based on the information obtained from the hazard and risk assessment and on the characteristics of the local ecosystem. [Pg.124]

Tran, L., Kelly, F., Mudway, I., Morin, J.P., Guest, R., Jenkinson, P., Samaras, Z., Giannouli, M., Kouridis, H. and Martin, P. (2008) Hazard and risk assessment of a nanoparticulate cerium oxide-based diesel fuel additive - a case study. Inhal. Toxicol., 20 (6), 547-566. [Pg.248]

HAZARD IDENTIFICATION RISK ANALYSIS Identify Hazards Evaluate Risks Assess Risks Make Risk-based Decisions Follow Through on Assessment Results Maintain a Dependable Practice... [Pg.166]

Several authors have provided comparative summaries of hazard and risk ranking tools. One publication organized examples of related hazard ranking tools according to a hierarchy based on the complexity of hazard and risk assessment decisions being supported. This relationship is shown in Figure 1. [Pg.1293]

See also Carcinogen Classification Schemes Dose-Response Relationship Exposure Assessment Exposure Criteria Hazard Identification Risk Assessment, Ecological Risk Based Corrective Action (RBCA) Risk Characterization Risk Communication Risk Management Uncertainty Analysis. [Pg.2316]

Effect parameters in hazard or risk assessment of chemicals for the aquatic environment are usually based on external effect concentrations for a few types... [Pg.13]

The information used to classify a chemical substance as dangerous , either to health or the environment, can be used for hazard assessment, which can be combined with chemical exposure data to produce a risk assessment. Further information on toxicity or exposure may be needed to refine the risk assessment, before any necessary risk management action is taken to ban or restrict the use of the chemical. (See also chapter by Cowie and Richardson.) Defined hazard and risk assessment procedures may be used by regulatffls, or informal assessments based on practical experience can be undertaken by chemical users, either voluntarily or to fulfil statutory obligations. [Pg.534]

Scenario-based safety risk assessment, where the calculation estimates the frequency with which the hazardous scenario will lead to the calculated consequence (a certain number of fatalities within the total exposed population). The distinction between this calculation and an Individual Risk calculation is that this calculation does not focus on any specific individual but instead considers and aggregates the impact on the whole population. A single scenario-based risk assessment does not account for all the sources of harm to which an individual may be exposed in a given establishment. When scenario-based LOPA is carried out. Individual Risk should also be considered to ensure that Individual Risk limits are not exceeded. [Pg.87]

Table 8 Is based on HSE s Guidance on ALARP decisions in control of major accident hazards (COMAH) SPC/Permissioning/12. Note that a scenario-based risk assessment with a single fatality is not the same as an Individual Risk calculation. [Pg.91]

Consistent with the obligation to ensure that compliance remains in the workplace (and not with Government) new performance based standards require hazard identification, risk assessment and risk control. Such activities are basic and necessary to a functional system of safety management, but the requirement introduces a subjective element into the process which continues to cause problems and disputes as to whether what has been done complies with the legal requirement (Dell, 2001). [Pg.16]

The safety integrity level (SIL 3 in this case) is allocated based on a process hazard and risk assessment. It forms the basis for the risk reduction target for the safety instrumented system/SIL (HIPS in this case). For on-demand systems such as a HIPS, the SIL defines the probability of... [Pg.187]

This is only general guidance. Actual on-site conditions or r ulatory requirements may dictate another hazard evaluation method. A paint inspection by itself may not identify lead-based paint hazards. A risk assessment inspection combination is an option whenever an assessment or inspection is indicated. A risk assessment screen is appropriate for buildings in good condition. Some jurisdications may limit choices in some circumstances. [Pg.54]

Under the current Lead-Based Paint Activities Regulations at 40 CFR, Part 745, Subpart L, both individuals and firms that perform lead-based paint inspections, lead hazard screens, risk assessments, and abatements must be certified by the U.S. Environmental Protection Agency (EPA), EPA proposed a similar, but not identical, regulatory scheme for individuals and firms that perform renovations. [Pg.139]

In this paper, we propose a structured method based on UML environment models supported by a tool. We assume that an item definition, hazard analysis, risk assessment and safety goals according to ISO 26262 are given (see e.g. [2]). In this paper, we focus on the next step the creation of a functional safety concept (FSC) in which we show how the functional safety requirements are systematically derived. In the FSC, additionally, requirements may be decomposed in order to lower the ASIL. Furthermore, the functional safety requirements are allocated to elements of a preliminary architecture. These aspects are appropriately described in the ISO 26262 and need no further explanation and improvement and are, therefore, not part of this paper. The contribution of our paper can be summarized as follows ... [Pg.66]


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See also in sourсe #XX -- [ Pg.239 ]




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