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Protein functionality

Maiorov V N and G M Crippen 1994. Learning About Protein Folding via Potential Functions. Proteins Structure, Function and Genetics 20 167-173. [Pg.576]

Much of protein engineering concerns attempts to explore the relationship between protein stmcture and function. Proteins are polymers of amino acids (qv), which have general stmcture +H3N—CHR—COO , where R, the amino acid side chain, determines the unique identity and hence the stmcture and reactivity of the amino acid (Fig. 1, Table 1). Formation of a polypeptide or protein from the constituent amino acids involves the condensation of the amino-nitrogen of one residue to the carboxylate-carbon of another residue to form an amide, also called peptide, bond and water. The linear order in which amino acids are linked in the protein is called the primary stmcture of the protein or, more commonly, the amino acid sequence. Only 20 amino acid stmctures are used commonly in the cellular biosynthesis of proteins (qv). [Pg.194]

Enzymes Degrading Macromolecules. Enzymes that degrade macromolecules such as membrane polysaccharides, stmctural and functional proteins, or nucleic acids, have all shown oncolytic activity. Treatment strategies include the treatment of inoperable tumors with pepsin (1) antitumor activity of carboxypeptidase (44) cytotoxicity of ribonudease (45—47) oncolytic activity of neuraminidase (48—52) therapy with neuraminidase of patients with acute myeloid leukemia (53) antitumor activity of proteases (54) and hyaluronidase treatment in the management of human soHd tumors (55). [Pg.308]

Functional proteins are also involved in high-affinity Ni transport for hydrogenase synthesis. One example is the nikABCDE gene cluster of Escherichia coli 20). NikA is a periplasmic Ni-binding protein. [Pg.286]

Proteins derive their powerful and diverse capacity for molecular recognition and catalysis from their ability to fold into defined secondary and tertiary structures and display specific functional groups at precise locations in space. Functional protein domains are typically 50-200 residues in length and utilize a specific sequence of side chains to encode folded structures that have a compact hydrophobic core and a hydrophilic surface. Mimicry of protein structure and function by non-natural ohgomers such as peptoids wiU not only require the synthesis of >50mers with a variety of side chains, but wiU also require these non-natural sequences to adopt, in water, tertiary structures that are rich in secondary structure. [Pg.18]

Halperin I, Ma B, Wolfson H, Nussinov R. Principles of docking an overview of search algorithms and a guide to scoring functions. Proteins 2002 47 409-43. [Pg.208]

A major requirement for structural studies is the availability of large quantities of pure, functional protein. Essentially all proteins are present in only very small quantities in native cells or tissues, so molecular biology techniques... [Pg.279]

The major androgen or androgen precursor produced by the adrenal cortex is dehydroepiandrosterone (DHEA). Most 17-hydroxypregnenolone follows the glucocorticoid pathway, but a small fraction is subjected to oxidative fission and removal of the two-carbon side chain through the action of 17,20-lyase. The lyase activity is actually part of the same enzyme (P450cl7) that catalyzes 17tt-hydroxylation. This is therefore a dual function protein. The lyase activity is important in both the adrenals and... [Pg.440]

Once a gene is cloned it is necessary to convert the information contained in it into a functional protein. There are a number of steps in gene expression (i) transcription of DNA into mRNA (ii) translation of the mRNA into a protein sequence and (iii) in some instances, post-translational modification of the protein. In discussing these steps in more detail, expression of a cloned insulin gene will be used as an example. [Pg.457]

A) Biological systems any biological entity, from a functional protein to an ecosystem virtual in silica) 3D models mathematical models... [Pg.4]

Proteins either strengthen the membrane structure (building proteins) or fulfil various transport or catalytic functions (functional proteins). They are often only electrostatically bound to the membrane surface (extrinsic proteins) or are covalently bound to the lipoprotein complexes (intrinsic or integral proteins). They are usually present in the form of an or-helix or random coil. Some integral proteins penetrate through the membrane (see Section 6.4.2). [Pg.448]

The serum L-PGDS/p-trace concentration shows a circadian variation with a nocturnal increase, which is suppressed during total sleep deprivation but not affected by deprivation of REM sleep (Jordan et ah, 2004). Whether or not L-PGDS is a dual-function protein in vivo and is involved in the production of PGD2 as well as in the transport of PGD2 or some other compound(s) remains to be elucidated. [Pg.369]

Two of the cytoskeletal components, the actin filaments and the microtubules have been studied with molecular rotors. The main component of the actin filaments is the actin protein, a 44 kD molecule found in two forms within the cell the monomeric globulin form (G-actin) and the filament form (F-actin). Actin binds with ATP to form the microfilaments that are responsible for cell shape and motility. The rate of polymerization from the monomeric form plays a vital role in cell movement and signaling. Actin filaments form the cortical mesh that is the basis of the cytoskeleton. The cytoskeleton has an active relationship with the plasma membrane. Functional proteins found in both structures... [Pg.297]

Ness, J.E., Kim, S., Gottman, A. etal. (2002) Synthetic shuffling expands functional protein diversity by allowing amino acids to recombine independently. Nature Biotechnology, 20, 1251-1255. [Pg.76]

Hanes, J. and Pluckthun, A. (1997) In vitro selection and evolution of functional proteins by using ribosome display. Proceedings of the National Academy of Sciences of the United States of America, 94, 4937-4942. [Pg.78]


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See also in sourсe #XX -- [ Pg.19 ]




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A Selective Survey of Ga Protein Structure and Function

Activator proteins, function engineering

Acyl carrier protein, function

Adipocyte lipid-binding protein function

Apolipoprotein protein function

Applications Protein Function

Applications in Protein Structure and Function Modeling

Assigning Enzyme Function from DNA Sequence or Recombinant Proteins

B5 Functionality of Proteins

Bacteria, protein structure-function studies

Bioactive Food Proteins and their Biological Functions

Biological Functions of Iron-Containing Proteins

Biological systems protein function

Blue copper proteins function

Calcium/calmodulin-dependent protein kinases function

Canola protein functional properties

Cell Division Activity, Errors in Function of Signal Proteins and Tumor Formation

Cell function proteins

Cellular retinol-binding protein function

Chaperone proteins, apoE function

Chemical protein function

Circular permutations, protein function

Cobalt protein-functionalized

Computational protein design energy function

Copper proteins functions

Cucumber basic blue protein function

Density functional theory protein-ligand interactions

Directed evolution of protein function

Elucidation of Protein Function by Chemical Modification

Engineering Control Over Protein Function

Escherichia coli, protein structure-function

Eukaryotic systems, protein structure-function

Eukaryotic systems, protein structure-function studies

Expression of Genes Encoded for Functional Proteins

FK506 binding proteins functions

FUNCTIONALITY AND PROTEIN STRUCTURE

Fatty acid-binding proteins function

Fluorescent proteins biological function

Fold and protein function

Food protein functional properties

Food protein ingredients functionality

Forming Functional Proteins

From Gene to Functional Protein Processing Steps in Plants

Function and Coordination Chemistry of Cd(II) in Metalloregulatory Proteins

Function of Cap-Binding Proteins

Functional Diversity of Proteins

Functional Domains of the P22 Scaffolding Protein

Functional Sites of Proteins

Functional analysis of RNA-protein complexes in vitro

Functional and Genomic Analysis of the Unfolded Protein Response

Functional annotation of proteins

Functional bioassays proteins

Functional coding principle, proteins

Functional general design, protein

Functional group targets proteins

Functional groups model protein reduction

Functional groups, modification, protein

Functional groups, of proteins

Functional milk proteins

Functional of proteins

Functional properties enzymatic protein processing

Functional properties food protein ingredients

Functional properties milk protein modification

Functional properties of proteins

Functional properties of soy proteins

Functional protein-functionalized

Functional protein-functionalized

Functional proteomics activity-based protein profiling

Functional targets Proteins

Functional testing, protein

Functional unfolded proteins

Functional units, protein patterns

Functions of Protein Kinase

Functions of Protein Tyrosine Phosphorylation

Functions of proteins

G protein function, scheme

G protein functions

G protein-coupled receptors structure and function

G-protein-coupled receptors functions

Gaussian functions/distribution proteins

Gene activation, functional proteins

General Classification and Function of Protein Kinases

Genomics - assigning function to genes and proteins

Globular proteins biological function

Globular proteins functions

HAT Proteins Function in Regulating Transcriptional Elongation

Heat shock proteins , function

Heme proteins functionalization

Heme proteins structure-function relationship

High-potential iron proteins function

Histidine Hydrogen Exchange for Analysis of Protein Folding, Structure, and Function

Human nutrition, protein functions

Influence of Glutathione Status on Sarcolemmal Protein Function

Intestine, fatty acid-binding proteins function

Iron protein structure-function correlation

Iron-sulfur proteins functions

Learning for Protein Structure and Function Prediction

Legume proteins, functionality

Ligand-functionalized protein-containing

Ligand-protein complexes, induction functional

Ligand-protein complexes, induction functionals

Linked functions heme proteins

Lipid-binding proteins function

Lipid-binding proteins physiological functions

Lipids matrix, function membrane proteins

Major urinary protein function

Mannose-binding proteins functions

Membrane channel protein, function

Membrane channel protein, function molecular model

Membrane proteins functions

Membrane proteins structure-function relationships, cellular

Milk proteins function

Milk proteins protein functions

Mixed-function oxidase protein

Mixed-function protein kinase

Modeling Flavin Coenzyme Function in Peptides and Proteins

Modeling Nicotinamide Coenzyme Function in Protein and Peptide Systems

Modulation of protein function

Mutagenesis, protein function analysis

Nitrogenase MoFe protein function

Nucleation proteins, function

PROTEIN FUNCTIONALITY IN FOODS

Photoswitchable Biomaterial Functions through Tethering of Photoisomerizable Units to Proteins

Physiological functions protein

Plasma proteins functions

Polymer-Binding Reprograms Domain Functions of Proteins

Polymeric Materials with Ionic Functional Groups and Their Protein Adsorptive Behavior

Potential energy functions protein force fields

Prokaryotic systems, protein structure-function

Prokaryotic systems, protein structure-function studies

Protective proteins, functions biological systems

Protein Data Bank scoring functions

Protein Detection via Functional Measurements

Protein Dynamics and Enzyme Functioning

Protein Folding Problems and Functional Sites

Protein Function Analysis

Protein Function Engineering Control

Protein Function Using Chemistry

Protein Function, Enzymes, and Enzyme Kinetics

Protein as function

Protein assemblies functionalization

Protein biological functions

Protein blocking functional

Protein catalytic function

Protein chips surface functionalization

Protein design energy function

Protein dynamics and their functional activity

Protein dynamics, as a function of hydration

Protein engineering functions

Protein folding function

Protein folding scoring function evaluation

Protein function

Protein function evolution

Protein function evolution combinatorial methods

Protein function evolution dehydrogenase

Protein function evolution deletions

Protein function evolution engineering

Protein function evolution expression improvement

Protein function evolution insertion

Protein function evolution modular proteins

Protein function evolution multidomain proteins

Protein function evolution overview

Protein function evolution proteases

Protein function evolution stability improvement

Protein function imaging

Protein function investigation

Protein function modulation

Protein function predictions

Protein function sarcolemmal

Protein function, during mammalian

Protein function, various effects

Protein functional

Protein functional group properties, influences

Protein functional groups

Protein functional properties

Protein functional properties, determination

Protein functional sites

Protein functional, formation

Protein functionalizations

Protein kinase Function

Protein modifying functional properties

Protein molecular evolution function

Protein movement function

Protein oxidation biological functions

Protein patterns, functional cell units

Protein properties and functionality

Protein protective function

Protein receptors, function

Protein regulatory function

Protein secretion, functional

Protein secretion, functional proteins

Protein sequencing amino acid function analysis

Protein storage function

Protein structural function

Protein transport function

Protein tyrosine phosphorylation cellular function

Protein-based approach predicting functional sites

Protein-based materials aqueous environment function

Protein-functionalized colloidal particles

Protein-ligand scoring functions

Proteins and function)

Proteins assigning functions

Proteins blocking functional groups

Proteins classification and function

Proteins crystals, functional properties

Proteins function definition

Proteins function observation

Proteins functional analysis

Proteins functional roles

Proteins functioning

Proteins functioning

Proteins functions, generally

Proteins immobilization with functional mesoporous

Proteins insights about function

Proteins retain their function in the crystal

Proteins structure and function

Proteins understanding catalytic function

Proteins, functional properties dispersibility

Proteins, functional properties emulsification

Proteins, functional properties foaming

Proteins, functional properties solubility

Proteins, functional properties surface activity

Proteins, functional properties terms Links

Proteins, functional properties wettability

Proteins, immobilization onto functionalized

Proteins, introduction function, mechanisms

Proteins, introduction function, regulation

Proteins, redox structure-function

Proteins: Structure, Function, and Bioinformatics

Rapeseed proteins functionality

Rational Design of Functional Proteins

Retinol-binding protein function

Ribosomes and Polyribosomes (Polysomes), Their Functions in the Structural Organization of Protein Biosynthesis

Ribosomes: site and function of protein synthesis

Rieske proteins function

Rieske-type proteins function

Scoring Functions for Protein-Ligand Recognition

Scoring functions tertiary protein structure

Sequence—function relationships proteins

Silk protein structure function relationship

Small Molecules protein function

Small molecule modulators of protein function

Solvent Accessibility of Functional Targets in Proteins

Solvent-protein interactions functional roles

Steroid Molecular Structure, Protein Interaction and Biological Function

Stress Proteins and Their Functions

Stress proteins functions

Structural proteins, functions biological systems

Structure and Function of Proteins

Structure and function of G protein-coupled receptors

Structure-function relationship, proteins

Structure-function studies, of proteins

Studying the Function of Proteins Using Chemical Probes with Unknown Polypharmacology

Superfamily Analysis Understanding Protein Function from Structure and Sequence

Surface functionalization for protein arrays

Synthetic Approach to the Structure and Function of Copper Proteins

The Challenge to Make Small-Molecule Modulators of Protein Function

The Functional Cycle of Heterotrimeric G-Proteins

The G proteins identified by function and purification

Therapeutic proteins, wound healing functions

Unknown proteins, predicting functions

VSV Functions that Affect Protein Synthesis Inhibition

Vegetable food proteins functionality

Virus coat proteins, structure-function

Virus-induced proteins functions

What Are the Many Functions of Proteins

Wheat proteins functional properties

Whey protein functional properties

Yeast, protein structure-function studies

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