Functional and Genomic Analysis of the Unfolded Protein Response

Functional and Genomic Analysis of the Unfolded Protein Response 

The previous section looked at examples in which detailed analysis of specific proteins identified as targets of the heat shock response has led to the identification of new molecular chaperones as well as an expanded view of the requirements for efficient protein production and folding. In this section we focus on how the use of DNA microarrays has provided a global view of the spectrum of targets of a specific stress response, the unfolded protein response (UPR), which plays a critical 

The ER also has a robust quality control system responsible for recognizing misfolded proteins and preventing their progress through the secretory pathway (for reviews, see Brodsky and McCracken, 1999 Ellgaard et al., 1999 Hurtley and Helenius, 1989). This quality control system provides the dual benefit of keeping folded proteins within 

Core oligosaccharide synthesis DPMI, PM 140, REIKI, SEC59 

Chaperones FKB2,JEM1, LHS1, SCJ1, YFR041Cb 

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III. Functional and Genomic Analysis of the Unfolded Protein Response. 353... 

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