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Drug receptor

To understand the estimation of average drug-receptor binding energies... [Pg.319]

Table 3. Equilibrium Dissociation Constants for Drug—Receptor Complexes In Vitro... Table 3. Equilibrium Dissociation Constants for Drug—Receptor Complexes In Vitro...
T. Kenakin, Pharmacological Analysis of Drug Receptor Interaction, 2nd ed.. Raven, New York, 1993 D. Oksenberg and co-workers. Nature, 360, 161 (1992). [Pg.284]

II. RELATIONSHIPS BETWEEN EXPERIMENTAL AND THEORETICAL APPROACHES TO STUDYING DRUG-RECEPTOR INTERACTIONS... [Pg.352]

Figure 1 A flow chart of experimental information about drug-receptor interaction. The objects of experimental and theoretical investigation are boxed, and the experimental information is circled. Figure 1 A flow chart of experimental information about drug-receptor interaction. The objects of experimental and theoretical investigation are boxed, and the experimental information is circled.
Figure 2 A flow chart of theoretical modeling drug-receptor interaction and relation to experiment. The objects of theoretical investigation are m rectangles, and the experimental information IS m the ovals. Figure 2 A flow chart of theoretical modeling drug-receptor interaction and relation to experiment. The objects of theoretical investigation are m rectangles, and the experimental information IS m the ovals.
It is amazing to note that complex processes such as drug binding to protein, activation of cells, and observation of syncytial cellular response should apparently so closely follow a model based on these simple concepts. This was not lost on A. J. Clark in his treatise on drug receptor theory The Mode of Action of Drugs on Cells [4] ... [Pg.12]

A classic example of where definitive experimental data necessitated refinement and extension of a model of drug-receptor interaction involved the discovery of constitutive receptor activity in GPCR systems. The state of the art model before this finding was the ternary complex model for GPCRs, a model that cannot accommodate ligand-independent (constitutive) receptor activity. [Pg.41]

Mathematical models are the link between what is observed experimentally and what is thought to occur at the molecular level. In physical sciences, such as chemistry, there is a direct correspondence between the experimental observation and the molecular world (i.e., a nuclear magnetic resonance spectrum directly reflects the interaction of hydrogen atoms on a molecule). In pharmacology the observations are much more indirect, leaving a much wider gap between the physical chemistry involved in drug-receptor interaction and what the cell does in response to those interactions (through the cellular veil ). Hence, models become uniquely important. [Pg.42]

Colquhoun, D. (1973). The relationship between classical and cooperative models for drag action. In A symposium on drug receptors, edited by H. P. Rang, pp. 149-182. University Park Press, Baltimore. [Pg.57]


See other pages where Drug receptor is mentioned: [Pg.326]    [Pg.487]    [Pg.315]    [Pg.240]    [Pg.274]    [Pg.278]    [Pg.359]    [Pg.362]    [Pg.21]    [Pg.140]    [Pg.3]    [Pg.6]    [Pg.13]    [Pg.16]    [Pg.17]    [Pg.21]    [Pg.34]    [Pg.34]    [Pg.41]    [Pg.41]    [Pg.41]    [Pg.42]    [Pg.42]    [Pg.42]    [Pg.42]    [Pg.42]    [Pg.43]    [Pg.44]    [Pg.46]    [Pg.48]    [Pg.50]    [Pg.52]    [Pg.54]    [Pg.56]    [Pg.58]    [Pg.59]    [Pg.81]    [Pg.87]   
See also in sourсe #XX -- [ Pg.326 ]




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Adverse drug reactions receptor

Affinity, drug-receptor

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Angiotensin-receptor blockers drug interactions

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Anti-ulcer drugs, histamine-2 receptor

Antiplatelet drugs receptor antagonists

Antipsychotic drugs dopamine receptor blockade

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Antipsychotic drugs serotonin receptor blockade

Antitussive drugs receptor specificity

Assay development drug receptors

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Binding interactions, drug receptor

Binding, drug-receptor distribution affected

Binding, drug-receptor interactions based

Bonds drug-receptor

Cells Cell surface receptors, drug

Chemical recognition mechanisms drug-receptor interactions

Chemokine Receptors as Drug Targets. Edited by Martine J. Smit, Sergio A. Lira, and Rob Leurs

Chemokine receptors drugs modulating

Complexity, drug-receptor interaction

Cooperativity drug receptor interactions

DRUG DISCOVERY TARGETS AND RECEPTORS

Definitions of Drug-Receptor Binding Interactions

Dopamine receptors drugs acting

Drug Interactions with Targets or Receptors

Drug Receptor Studies

Drug absorption receptor-mediated endocytosis

Drug action drugs that target receptors

Drug action receptor theory

Drug and receptor

Drug antagonism receptor

Drug delivery receptor interaction

Drug delivery systems receptor-mediated endocytosis

Drug design receptor structure

Drug design receptor-bound conformation

Drug neurotransmitter receptors

Drug receptor based

Drug receptor interaction

Drug receptor-interaction irreversible

Drug receptor-interaction mechanisms

Drug receptors regulation

Drug targets intracellular receptors

Drug-Receptor Binding Energies

Drug-receptor analysis

Drug-receptor binding

Drug-receptor complex

Drug-receptor electrostatic interactions

Drug-receptor encounters

Drug-receptor interactions cooperative binding

Drug-receptor interactions enthalpy/entropy compensation

Drug-receptor interactions entropy

Drug-receptor interactions free energy

Drug-receptor interactions functional group contributions

Drug-receptor interactions hydrogen bonds

Drug-receptor interactions hydrophobic

Drug-receptor interactions inductive

Drug-receptor interactions lead compounds

Drug-receptor interactions principles

Drug-receptor interactions stereochemistry

Drug-receptor interactions, forces

Drug-receptor interactions, hydrogen

Drug-receptor molecular pharmacological techniques

Drug-receptor quantitative analysis

Drug-receptor recognition

Drugs association with receptors

Drugs chemokine receptor modulated

Drugs receptors for

Drugs targeting /1-adrenergic receptor

Enantiomers drug-receptor interactions

Experimental Quantification of Drug-Receptor Binding Interactions

Functional groups drug-receptor interactions

GABA receptors hypnotic drugs

General Molecular Concepts of Drug Receptor Action

Geometry drug-receptor complex

Glycine (Gly drugs binding to receptors

Hormone receptor drug binding

Hydroxyl group drug-receptor interactions

Hypotensive drug 2 receptor agonist

IUPHAR Committee on Receptor Nomenclature and Drug

Identical twin drugs receptor ligands

Intracellular receptors drug development

Intracellular receptors drug interactions

Ionic bonds, drug receptor interactions

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Methyl group drug-receptor interactions

Molecular drug targets nuclear receptors

Molecular drug targets receptors

Molecular drug-receptor interaction

Multi-receptor drug

Neuroleptic drugs dopamine receptors

Neuropeptide receptor-acting drugs

Nuclear Receptor-Mediated Regulation of Drug Transporters

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Nuclear receptor drug discovery

Opioid analgesic drugs receptors

Orphan receptors drug discovery using

Pharmacodynamics drug-receptor interactions

Pharmacokinetics and Drug Receptors

Post-Receptorome Screening Data Implicate 5-HT2b Receptors in Drug-Induced VHD and PH

Potency, drugs receptor role

Pro-drugs of dopamine receptor agonists

Receptor access, drug design

Receptor affinity antidepressant drugs

Receptor binding drug design

Receptor characterization drug design

Receptor patches destruction by drugs

Receptor stimulating adrenergic drugs

Receptor-Mediated Endocytosis and Drug Absorption

Receptor-based drug design

Receptor-based drug discovery

Receptor-based drug targeting

Receptor-drug interactions bond types

Receptor-drug interactions conformational change

Receptor-drug interactions rate theory

Receptors as drug targets

Receptors bound drugs

Receptors drug development

Receptors drug targets

Receptors drug-receptor interactions

Receptors drug-target residence time

Receptors drugs that target

Receptors interaction with drugs

Receptors neuroleptic drugs

Scoring Drug-Receptor Interactions

Scoring functions drug receptor

Selecting a Receptor Appropriate for Drug Design

Selective drugs, activity toward receptors

Selective estrogen receptor modulators drugs

Serotonin receptors, drug design/discovery

Serpentine receptors, drug

Significance of chemical bonding in drug-receptor interactions

Stereospecificity, drug-receptor

Stereospecificity, drug-receptor interactions

Steric hindrance drug-receptor interactions

Structure-activity relationships drug-receptor interactions

Sympathomimetic drug Adrenergic receptor

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That Influence Drug Receptors

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The Role of Functional Groups in Drug-Receptor Interactions

The Strengths of Functional Group Contributions to Drug-Receptor Interactions

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Transgenic animals humanized drug receptors

Twin drugs receptor ligands

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