Receptor stimulating adrenergic drugs

Sympathetic blocking agent. A drug that binds to, but does not stimulate, adrenergic receptors of the 3-type. 

Albuterol is a bronchodilator used in inhalation aerosols for the treatment of asthma. It is a P2-adrenergic drug. The bronchial muscles are controlled by P2 receptors. Stimulation of the P2 receptors leads to the relaxation of the bronchial muscles and the opening of the airways. But it must not encourage a stimulation, leading to vasoconstriction, or Pi stimulation, giving an... 

Propranolol has two separate and distinct effects. The first is a consequence of the drug s (3-blocking properties and the subsequent removal of adrenergic influences on the heart. The second is associated with its direct myocardial effects (membrane stabilization). The latter action, especially at high clinically employed doses, may account for its effectiveness against arrhythmias in which enhanced (3-receptor stimulation does not play a significant role in the genesis of the rhythm disturbance. 

Methoxamine [meth OX a meen] is a direct-acting synthetic adrenergic drug that binds primarily to a receptors, with a-i receptors favored over 0C2 receptors. Methoxamine raises blood pressure by stimulating ai receptors in the arterioles, causing vasoconstriction. This causes an increase in total peripheral resistance. Because of its effects on the vagus, methoxamine is used clinically to relieve attacks of paroxysmal supraventricular tachycardia. It is also used... 

At low doses, the drug primarily stimulates the I), receptor. At high therapeutic doses, dopamine stimulates adrenergic receptors, primarily the cardiac receptor and vascular a, receptor. 

Pindolol is a partial agonist at the P2-adrenergic receptor, and has antagonistic actions at the P,-receptor. Thus, cardiac output is reduced with the drug, due to p,-receptor antagonism, and vasodilatation is increased, due to the effects of p2-receptor stimulation. 

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