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Drug-receptor encounters

As a first example in this regard, it is of interest to consider a study reported by E. Clementi and collaborators (108) in 1978. In this paper, the manner of treating enzymic reactions using theoretical techniques was generalized substantially from earlier work. Since the description of enzyme-substrate interactions encounters the same kinds of difficulties as the description of drug-receptor interactions, this study may provide a good indication of new directions and capabilities that can be expected to develop further in the near future. [Pg.16]

One of the strengths of Schild analysis is the capability of unveiling nonequilibrium conditions in experimental preparations such as inadequate time of equilibration or removal of drugs from the receptor compartment. Figure 6.11 shows a range of possible experimentally observed but problematic linear Schild regressions that could be encountered for competitive antagonists. [Pg.108]

All the mechanisms we have encountered, which affect the way in which a drug is handled by the body, are important for one major reason - they all work together to determine how much drug is present at any given time at the point in the body where the drug acts - its effector site. Commonly this is at a receptor site in particular cells and organs, and the... [Pg.130]


See other pages where Drug-receptor encounters is mentioned: [Pg.28]    [Pg.221]    [Pg.28]    [Pg.221]    [Pg.163]    [Pg.490]    [Pg.387]    [Pg.47]    [Pg.483]    [Pg.31]    [Pg.94]    [Pg.2]    [Pg.184]    [Pg.25]    [Pg.179]    [Pg.45]    [Pg.232]    [Pg.33]    [Pg.36]    [Pg.304]    [Pg.1010]    [Pg.886]    [Pg.693]    [Pg.136]    [Pg.144]    [Pg.177]    [Pg.30]    [Pg.17]    [Pg.60]    [Pg.183]    [Pg.24]    [Pg.98]    [Pg.81]    [Pg.221]    [Pg.598]    [Pg.145]    [Pg.271]    [Pg.15]    [Pg.107]    [Pg.253]    [Pg.170]    [Pg.29]    [Pg.127]    [Pg.291]    [Pg.93]    [Pg.108]    [Pg.304]    [Pg.1010]   
See also in sourсe #XX -- [ Pg.221 ]




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Drug-receptor

Encounter

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