Angiotensin receptor blockers drugs

Calcium-channel blockers such as amlodipine can be used in patients receiving angiotensin-receptor blockers such as valsartan for the treatment of hypertension and angina. Side-effects common to both drugs include dizziness and hypotension. 

Mangoni AA, Jackson SH. The implications of a growing evidence base for drug use in elderly patients Part 2. ACE inhibitors and angiotensin receptor blockers in heart failure and high cardiovascular risk patients. Br J Clin Pharmacol 2006 61(5) 502-12. 

Sites of action of drugs that interfere with the renin-angiotensin-aldosterone system. ACE, angiotensin-converting enzyme ARBs, angiotensin receptor blockers. 

Treatment with angiotensin-converting enzyme inhibitors is also more likely to be associated with hyperkalemia in older individuals (69). Impaired angiotensin II formation limits this potent stimulus for aldosterone secretion, and this is superimposed on the already age-related decrease in activity of the renin-angiotensin-aldosterone axis. The same drug-induced hyporeninemic hypoaldosteronism is predicted for the angiotensin receptor blockers. However, to date this has not been documented clincally. 

In the patient with chronic angina, the drugs commonly used seem to offer important myocardial protection Thus, (3-blockers, ACE inhibitors and most probably angiotensin receptor blockers, statins, Ca2+ channel blockers, all are in their way cardioprotective. Nitrates and more importantly nicorandil are worthwhile options. Trimetazidine and drugs producing a shift towards preferential glucose oxidation would also be a consideration. A number of studies stress that they may produce an improvement in ischemic cardiomyopathy, probably through an anti-inflammatory action.261... 

Triazoles and tetrazoles do not exist in nature. However, many synthetic medicines do contain triazoles and tetrazoles. For instance, valsartan, an angiotensin receptor blocker (ARB) indicated for heatment of high blood pressure and other cardiovascular disease contains a tetrazole. Anastrozole contains a 1,2,4-triazole and is an aromatase-inhibiting drug approved for treatment of breast cancer. Tazobactam is a 1,2,3-triazole containing compound that inhibits the action of bacterial -lactamases and is used to treat bacterial infection in combination with the beta-lactam antibiotic piperacillin. ... 

Several standard drug therapies can markedly improve survival from cardiovascular disease in select patient populations. These include j8-blockers (77-79), aspirin (80,81), angiotensin converting enzyme (ACE) inhibitors (82,83), angiotensin receptor blockers (ARBs) (84-86), anticoagulants (including warfarin and aspirin) (87-90), aldosterone antagonists (91), and HMG-CoA reductase inhibitors (78-80,83,86,92-98). 

High dietary potassium has been linked to lower blood pressure, and dietary supplementation with moderate amounts of potassium has been found to lower blood pressure. Many drugs have effects in either raising or lowering potassium levels in the body. Levels are raised by digoxin, trimethoprim-sulfamethoxazole, ibuprofen, ACE inhibitors, angiotensin receptor blockers, spironolactone and heparin. Levels of potassium are lowered by diuretics, corticosteroids pseudoephedrine, some penicillins, carbenoxolone, caffeine and theophylline. 

Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers decrease protein excretion and are the drugs of choice for hypertension in patients with CKD. 

For women with 140 to 179 mm Hg systolic or 90 to 109 mm Hg diastolic, the decision to continue or stop antihypertensive therapy during pregnancy is controversial. Antihypertensive drugs may be continued during pregnancy except for ACEIs and angiotensin II receptor blockers. 

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