DNA-drug binding

Diaminopyrimidines, 19 (1982) 269 Digitalis recognition matrix, 30 (1993) 135 Diuretic drugs, 1 (1961) 132 DNA-binding drugs, 16 (1979) 151 Dopamine D2 receptor agonists,... 

The ability of DNA-binding drugs to induce chromatin condensation calls for in-depth studies, because the biological consequence of chromatin condensation is its loss of transcriptional ability. Therefore it might be a mechanism of transcription inhibition by the reversible DNA binders. The first report in this line (Sen and Crothers, 1986) employed transient electric dichroism to study the ability of the drugs to induce folding of chromatin from the 10- to 30-nm fiber either by... 

Seenisamy J, Bashyam S, Gokhale V, Vankayalapati H, Sun D, Siddiqui-Jain A, Streiner N, Shin-Ya K, White E, Wilson WD, Hurley EH (2005) Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure. J Am Chem Soc 127(9) 2944-2959 Sen D, Crothers DM (1986) Influence of DNA-binding drugs on chromatin condensation. Biochemistry 25(7) 1503-1509... 

S. Neidle (1979). The molecular basis of action of some DNA-binding drugs. In G. P. Ellis and... 

Triolo, A., Arcamone, F.M., Raffaeli, A. and Salvadori, P. (1997) Non-covalent complexes between DNA-binding drugs and double-stranded deoxyoligonucleotides a study by ionspray mass spectrometry. J. Mass Spectrom., 32 (11), 1186-94. 

Dickerson, R. E., and Kopka, M. L. Rational design of DNA-binding drugs or How to read a helix. In Patterson and Pattersons. Fifty Years of the Patterson Function. (Eds., Glusker, J. P., Patterson, B. K. and Rossi, M.) Ch. 12. pp 252-278. International Union of Crystallography/Oxford University Press New York (1987). 

Wan, K.X. Shibue, T. Gross, M.L. Non-Covalent Complexes Between DNA-Binding Drugs and Double-Stranded Oligodeoxynucleotides A Study by ESI Ion-Trap Mass Spectrometry, J. Am. Chem. Soc. 122, 300-307 (2000). 

DG has been used to propose novel antifolates,as well as DNA-binding drugs, antiviral agents, and others, Further discussion of DG can be found elsewhere. 

Several DNA binding drugs that act as bifunctional alkylating agents and are able to... 

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