Pro-drugs of dopamine receptor agonists

Application of prodrugs has involved (1) enhancement of bioavailability and passage through various biological barriers, (2) increased duration of pharmacological effects, (3) increased site-specificity, (4) decreased toxicity and adverse reactions, (5) improvement of organoleptic properties and (6) improvement of stability and solubility properties.184 

Since a lot of the dopamine receptor agonists possess catechol or phenol moieties, the most frequently investigated prodrugs are esters and carbamates of these hydroxylated compounds.96 185 187 

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