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Assay development drug receptors

A label-free comprehensive platform for functional evaluation of endogenous receptors. Assay and Drug Development Technologies, 4 (5), 609-619. [Pg.295]

Because the chemical structure of a molecule encodes its biological properties, structure has long served as the primary variable and determinant for the discovery of new drugs by medicinal chemists. For this reason, systematic structural modification has been the primary tool of choice to isolate and enhance a desired biologic activity. Moreover, with the relatively recent development of in vitro receptor-binding assays, combinatorial methods of chemical synthesis, and computer graphics, the overall approach to structural modification has become increasingly sophisticated. [Pg.18]

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See also in sourсe #XX -- [ Pg.45 ]



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