Multi-receptor drug

PETERSON G and BARNES s (1991) Genistein inhibition of the growth of hiunan hreast cancer cells independence from estrogen receptors and the multi-drug resistance gene. Biochem Biophys Res Commun. 179 (1) 661-7. 

In addition to epilepsy, neuronal death due to the toxic effects of glutamate has also been implicated in cerebral ischaemia associated with multi-infarct dementia and possibly Alzheimer s disease. With the plethora of selective excitatory amino acid receptor antagonists currently undergoing development, some of which are already in clinical trials, one may expect definite advances in the drug treatment of neurodegenerative disorders in the near future. 

De Lean A, Munson PJ, Rodbard D. Multi-subsite receptors for multivalent ligands. Application to drugs, hormones, and neurotransmitters. Mol Pharmacol 1979 15 60-70. 

The choice of model should be based on biological, physiological, and pharmacokinetic plausibility. For example, compartmental models may be used because of their basis in theory and plausibility. It is easy to conceptualize that a drug that distributes more slowly into poorly perfused tissues than rapidly perfused tissues will show multi-phasic concentration-time profiles. Alternatively, the Emax equation, one of the most commonly used equations in pharmacodynamic modeling, can be developed based on mass balance principles and receptor binding kinetics. 

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