Nuclear receptor drug discovery

Recent Progress in Nuclear Receptor Drug Discovery 9... 

In the introductory chapter a very brief overview on historic developments in nuclear receptor drug discovery from the pioneering experiments up to our current knowledge is given by Eckhard Ottow and Hilmar Weinmann. 

Moore JT, Collins JL, Pearce KH (2006) The nuclear receptor superfamily and drug discovery. Chem Med Chem 1 504-523... 

Xie, W., Uppal, H., Saini, S.P., Mu, Y., Little, J.M., Radominska-Pandya, A. and Zemaitis, M.A. (2004) Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism. Drug Discovery Today, 9, 442-449. 

Pearce KH, larmone MA, Simmons CA, et al. Discovery of novel nuclear receptor modulating ligands an integral role for peptide interaction profiling. Drug Discov Today 2004 9 741-51. 

Pharmacological knowledge, gained with the discovery of steroid hormones, their nuclear receptors and their function in normal and malignant tissues, has been successfully translated into the first targeted drugs in oncology. 

Waxman DJ (1999) P450 gene induction by structurally diverse xenochemicals central role of nuclear receptors CAR, PXR, and PPAR. Arch Biochem Biophys 369 11-23 Yang Y, Blomme EA, Waring JF (2004) Toxicogenomics in drug discovery from preclinical studies to clinical trials. Chem Biol Interact 150 71-85... 

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