Fischer 344 rats

CHUNG F L, CONAWAY c c, RAO c V and REDDY B s (2000) Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate . Carcinogenesis, 21 2287-91. 

CHUNG F L, KELLOFF G, STEELE V, PITTMAN B, ZANG E, JIAO D, RIGOTTY J, CHOI C I and RiVENSON A (1996) Chemopreventive efficacy of arylalkyl isothrocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats . Cancer Res, 56 772-8. 

Sugawara, N., D. Li, M. Katakura, and C. Sugawara. 1994. Biliary excretion of copper in Fischer rats treated with copper salt and in Long-Evans Cinnamon (LEC) rats with an inherently abnormal copper metabolism. Biol. Trace Elem. Res. 46 125-134. 

Kasprzak, K.S., R.M. Kovatch, and L.A. Poirier. 1988. Inhibitory effect of zinc on nickel subsulfide carcinogenesis in Fischer rats. Toxicology 52 253-262. 

Boorman, G.A., S.L.Eustis, and M.R.Elwell. 1990. Pathology of the Fischer Rat Reference and Atlas. New York Academic Press, Inc. 

Chlorfenvinphos [470-90-6] male Fischer rats LC5o(4-h) -0.89 Takahashi et al., 1994... 

However, subsequent studies did not find clear evidence to support the view that bile acids could independently stimulate tumour formation utilising rat models. Rather, the findings indicated that bile acids could enhance the effect of other carcinogens in these models. An example of such a study is by McSherry et al. in which male Fischer rats were fed diets supplemented with cholic acid (0.2%) and administered the colonic carcinogen, A-Methyl-A-nitrosurea (MNU), intra-rectally. Fifty-five per cent of MNU treated rats on standard diet developed tumours, a figure that increased to eighty per cent in MNU-treated rats given dietary cholic acid. Rats fed cholic acid supplemented diet alone did not develop tumours. 

MNNG ir male/female CD-Fischer rat LCA/tauro-DCA Narisawa et al., 1974 ... 

Mononuclear Cell Leukemia (MNCL) is unique to the rat, and is only common in the F-344 (common name Fischer rat) inbred rat strain, which is the strain used by the U.S. National Toxicology Program (NTP). Elevated incidences of MNCL have been observed in a number of chronic bioassays in the F-344 rat. The frequency differs between males and females, with an incidence in males around 50%, and an incidence in females around 30%, with a large variation from study to study. It has been shown for some genotoxic carcinogens that exposure does not lead to an increase in MNCL in the F-344 rat, while a number of substances, which are believed to be noncarcinogens,... 

Atrazine was not carcinogenic to mice or Fischer rats after oral administration in the diet. An increase incidence of mammary tumors has been found in female Sprague-Dawley females treated similarly. The lARC has determined that the mammary tumors associated with atrazine exposure involve a mechanism that is non-DNA-reactive and hormonally mediated. They further stated that this mechanism is not relevant to humans. The lARC concluded that there was sufficient evidence for the carcinogenicity of atrazine in experimental animals and inadequate evidence of carcinogenicity in humans. ... 

Lijinsky W, Reuber MD Comparative carcinogenesis by some aliphatic nitrosamines in Fischer rats. Cancer Lett 14 297-302, 1981... 

Lijinsky W, Reuber MD Carcinogenesis in Fischer rats by nitrosodipropylamine, nitro-sodibutylamine and nitrosobis(2-oxopropyl) amine given by gavage. Cancer Lett 19 207-213, 1983... 

Rosenbaum, G. A. Morrill and E. Bloch. Effects of cannabinoids on reproductive organs in the female Fischer rat. Adv Biosci Marihuana Biological Effects 1978 22 441-447. 

Intestinal neoplasia. Oil was administered to 8-week-old male Fischer rats divided into two groups of 60 each (sedentary and exposed to moderate exercise), at a dose of 21% of diet for 38 weeks. The exercising and sedentary rats fed coconut oil were significantly heavier than rats fed corn oil. In the rats fed coconut oil diet, nine carcinomas were recorded in the sedentary groups and five in the exercised rats, which developed significantly fewer neoplasms than corn oil-fed group ". 

CN173 Thorling, E.B., N. O. Jacobsen, and K. Overvad. The effect of treadmill exercise on azoxymethane-induced intestinal neoplasia in the male Fischer rat on two different high-fat diets. Nutr... 

Groups of 18-20 male Fischer rats (weighing 160 g) were given a single intra-peritoneal injection of 200 mg/kg bw NDEA. Two weeks later, they were fed a diet containing 3000 ppm di(2-ethylhexyl) phthalate [purity unspecified] for six weeks. At week 3, they were subjected to a partial hepatectomy. All rats were killed at week 8. Di(2-ethylhexyl) phthalate-treated rats had no increase in foci staining positively for glutathione S-transferase placental form (8.5 per cm versus 11.6 for NDEA alone) (Ito etal., 1988). 

RLV/Fischer rat assay without the addition of an exogenous metabolic activation system. In a single study, mouse JB6 epidermal cells were transformed by di(2-ethyl-hexyl) phthalate without activation and in one of two studies a weak response was reported in the CSHIOT A cell transformation assay with di(2-ethylhexyl) phthalate in either the absence or presence of exogenous metabolic activation. BALB/c-3T3 cells were not transformed by di(2-ethylhexyl) phthalate with or without metabolic activation. Di(2-ethylhexyl) phthalate inhibited gap-junctional intercellular communication in Chinese hamster V79 cells in six of seven studies, but not in one study of liver cells of cynomolgus monkeys in vivo. Di(2-ethylhexyl) phthalate treatment of Syrian hamster embryo cells in a two-stage exposure with 12-O-tetradecanoylphorbol 13-acetate resulted in superinduction of ornithine decarboxylase, an early event in morphological transformation no effect was seen after a one-stage treatment with di(2-ethylhexyl) phthalate alone. 

Suk, W.A. Humphreys, J.E. (1985) Assay for the carcinogenicity of chemical agents using enhancement of anchorage-independent survival of retroviras-infected Fischer rat embryo cells. Prog. Mutat. Res., 5, 673-683... 

Cell transformation, RLV/Fischer rat embryo cells Cell transformation, SA7/Syrian hamster embryo cells... 

Beitner-Johnson, Dana, Xavier Guitart, and Eric J. Nestler. 1991. "Dopaminergic Brain Reward Regions of Lewis and Fischer Rats Display Different Levels of Tyrosine Hydroxylase and Other Morphine- and Cocaine-Regulated Phosphoproteins." Research 561 147-50. 

K. Aghajanian, and Eric J. Nestler. 1993. "Lewis and Fischer Rat Strains Display Differences in Biochemical, Electrophysiologica), and Behavioral Parameters Studies in the Nucleus Accumbens and Locus Coeruleus of Drug Naive and Morphine-Treated Animals." Brain Research 611 7-17. 

Another study in Fischer rats demonstrated that MSCs do not elicit an immune response after transplantation in immunocompetent recipients. Syngeneic Fischer MSCs or allogeneic ACI MSCs were implanted via an osteoconductive matrix into the bilateral femoral gap of Fischer rats who were then sacrificed at 3, 6 and 12 weeks post-implantation (n = 4 per time point). Histological analysis showed there was no difference between the syngeneic or allogeneic implants. Allogeneic implants did not induce significant inflammatory cell infiltration or stimulate alloreactive T-cell responses [656702]. 

In vivo HMSC engraftment and migration Fischer rat MSCs were infused intraportally into the livers of other Fischer rats (2 million cells/rat) Results showed cells to persist for at least 28 days, being localized to the portal triad regions 643859... 

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