Tumors, colon

PERRIN F, PERRIN P, CHAMP M, BORNE, F, MEFLAH K, MENANTEAU J (1997) Short-chain frUCtO-oligosaccharides rednce the occurrence of colon tumor and develop gut-associated lymphoid tissue in Min mice. Cancer Res. 57 225-8. 

VERGHESE M, RAO D R, CHAWAN C B, WILLIAMS L L, SHACKELFORD L (2002) Dietary inului suppresses azoxymethane-induced aberrant crypt foci and colon tumors at the promotion stage in young fisher 344 rats. J. Nutr. 132 2809-2813. 

With XA1PcS3, selective photonecrosis of colonic tumors induced with dimethylhydrazine was observed with low drug doses (0.5 mg kg-1), but selectivity over normal tissue disappeared at 5 mg kg-1.329 The use of this material (in the form of PHOTOSENS as a mixture of di- and tri-sulfonic acids (7)) in extensive clinical treatments in Moscow has been referred to in Section 9.22.4. 

Chen MF, Chen LiT and Boyce HW, Jr. 1995. Cruciferous vegetables and glutathione their effects on colon mucosal glutathione level and colon tumor development in rats induced by DMH. Nutr Cancer 23(1) 77—83. 

Raicht RF, Cohen BI, Fazzini EP, Sarwal AN and Takahashi M. 1980. Protective effect of plant sterols against chemically induced colon tumors in rats. Cancer Res 40 403—405. 

The other well-known member of this superfamily is CEA or carcinoem-bryonic antigen. CEA is a widely used tumor marker, especially for monitoring patients with diagnosed colorectal cancer (M5). It is a high-molecular-weight (Afr 200,000, approximately) glycoprotein containing about 60% carbohydrate. In normal colonic cells and in well-differentiated colon carcinomas, the distribution of CEA is apical. However, in undifferentiated colonic tumors, CEA is present on all of the cell membrane (J3). Whether this altered subcellular localization of CEA mediates cancer spread is presently unclear. 

While dEpoB performed similarly to paclitaxel in sensitive tumor xenografts (MX-1 human mammary and HT-29 colon tumor), clearly superior effects of dEpoB were observed against MDR tumors under these slow infusion conditions. Thus, dEpoB (6 h, Q2D, 30 mg/kg x 5 doses, i.v.) demonstrated a foil curative effect when administered to nude mice bearing the resistant human lymphoblastic T-cell leukemia,... 

Da Violante, G., Zerrouk, N., Richard, I., Provot, G., Chaumeil, J.C., and Arnaud, P., Evaluation of the cytotoxicity effect of dimethylsulfoxide (DMSO) on Caco2/TC7 colon tumor cell cultures, Biol. Pharm. Bull., 25,1600, 2002. 

Colbern GT, Dykes DJ, Engbers C, et al. Encapsulation of the topoisomerase I inhibitor GL147211C in pegylated (STEALTH) liposomes pharmacokinetics and antitumor activity in HT29 colon tumor xenografts. Clin Cancer Res 1998 4 3077. 

Draesne N, Pagniez A, Mayeur C, Thomas M, Cherbuy C, Duee PH, Martel P, Chaumontet C. (2004) Dially disulfide (DADS) increase histone acetylation and p21/wafl/cipl expression in human colon tumor cell lines. Carcinogenesis 25 1227-1236. 

Recently, the piperazine intermediate 15 for the total synthesis of (—)-lemon-omycin (9) was reported by Fukuyama et al. [14], (—)-Lemonomycin possesses interesting antibiotic activity against methiciUin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium, as well as cytotoxicity against the human colon tumor cell line HCT-116 [15]. The reaction of 2-isocyanoethyl phenyl carbonate 11 gave Ugi product 14, which was further transformed to a piperazine intermediate 15 (Scheme 2). 

Pence BC, Buddingh E Co-carcinogenic effect of carbon black ingestion with dietary fat on the development of colon tumors in rats. Toxfro/37 177-182, 1987... 

Of all the 4-anilino-3-quinoHnecarbonitrile dual Src/Abl inhibitors, the most extensively profiled analog is SKI-606. Pharmacokinetics showed SKI-606 to have an oral bio availability in nude mice of 18% and a half-hfe of 8.6 hours with a large volume of distribution [122]. SKI-606 was active in several colon tumor xenograft models when dosed orally at 25-150 mg/kg daily for 21 days with no weight loss or overt toxicity noted in the animals. On the basis of its pre-clinical properties, SKI-606 entered clinical trials in 2004 for the treatment of solid tumors and will soon be entering trials for the treatment of CML. 

Phan SC, Morotomi M, Guillem JG, LoGerfo P, Weinstein IB (1991) Decreased levels of 1,2-sn-diacylglycerol in human colon tumors. Cancer Res 51 1571-1573 Piovesan B, Pennell N, Berinstein NL (1998) Human lymphoblastoid cell lines expressing mutant p53 exhibit decreased sensitivity to cisplatin-induced cytotoxicity. Oncogene 17 2339-2350... 

Selective COX-2 inhibitors have also been shown to prevent early and late forms of colorectal neoplasia in rat models. Reddy et al. showed that administration of celecoxib inhibited aberrant colonic crypt foci (ACF) induction and multiplicity by about 40-49% in an azoxymethane-induced ACF rat model (81). Later the same investigators also showed that dietary administration of celecoxib can inhibit both the incidence and multiplicity of colon tumors by about 93 % and 97 %, respectively in the same rat model (82). Other researchers reported similar results with the Min mouse model (52). There is little data on human clinical trials with selective COX-2 inhibitors for colorectal tumor prevention. Recently Steinbach et al. conducted a double-blind, placebo-controlled study with 77 patients with FAP, and reported that treatment with celecoxib, a selective COX-2 inhibitor, for 6 mo led to a significant reduction (28%) in the number of colorectal polyps in these patients (50). Collectively, COX-2 nonspecific or specific NSAIDs appear to have chemopreventive activity against colorectal cancer development. Selective... 

C. Punt, A. van der Kogel, A. Heerschap, Carbogen breathing differentially enhances blood plasma volume and 5-fluorouracil uptake in two murine colon tumor models with distinct vascular structures. Proc. Inti. Soc. Mag. Reson. Med. (Seattle) 2006, p. 1766. 

Carcinogenesis inhibition. Polysaccharide fraction of the dried seed hulls, administered to rats by gastric intubation, was active vs tumor induction with N-ethyl N-nitro-N nitrosoguanidine h Rice bran, administered orally to male rats at a concentration of 4% of the diet, was active. A 1 1 combination of wheat bran and psyllium, at a total level of 8% dietary fiber, offers the highest protection against colon tumor development . 

Rodriguez-Cabezaz, M. E., ]. Galvez, M. D. Lorente, et al. Dietary fiber down-regulates colonic tumor necrosis factor alpha and nitric oxide production in trinitrobenzenesulfonic acid-induced colitis rats. J Nutr 2002 132(11) 3263-3271. 

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