Dimethylhydrazine-induced tumors

Table III. Dimethylhydrazine-induced tumors in rats fed lyophilized charcoal broiled beef, raw beef or soybean protein...

Deschner, E. E., Florence, C. L., Hakissian, M., and Hermann, S. L., 1983, Differential susceptibility of AKR, C57BL/6J and CFl mice to 1,2-dimethylhydrazine induced tumor formation predicted by proliferative characteristics of colonic epithelial cells, J. Natl. Cancer Inst. 70 279. 

Deschner, E.E., Long, EC. Hakissian, M. (1988) Susceptibility to 1,2-dimethylhydrazine-induced colonic tumors and epithelial cell proliferation characteristics of FI, F2, and reciprocal backcrosses derived from SWR/J and AKR/J parental mouse strains. Cancer, 61, 478-482... 

The Bowman-Birk inhibitor also blocks the transformation of C H/10T1/2 cells (18). This raises the speculation that BB may represent a direct acting nutritionally relevant anticarcinogen particularly in the case of colon cancer. In this regard it was recently reported that e-aminocaproic acid (a trypsin inhibitor) inhibits dimethylhydrazine-induced colon tumors in mice (22). 

Asano T, Pollard M. 1978. Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germlfee rats (40146). Society for Experimental Biology and Medicine 158 89-91. 

Cook MG, McNamara P. 1980. Effect of dietary vitamin E on dimethylhydrazine-induced colonic tumors in mice. Cancer Res 40 1329-1331. 

Llor X, Jacoby RF, Teng BB, et al. 1991. K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors Effects of supplemental dietary calcium and vitamin D deficiency. Cancer Res 51 4305-4309. 

Siegers CP, Siemers J, Baretton G. Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice. Pharmacology 1993a 47(Suppl l) 205-8. 

Inhibition of 1,2-dimethylhydrazine-induced aberrant crypts and tumors in the colon... 

Wilson, R. B., Hutcheson, D. P., and Wideman, L., 1977, Dimethylhydrazine induced colon tumors in rats fed diets containing beef fat or corn oil with and without wheat bran. Am. J. Clin. Nutr. 30 176. 

Fukui, M., Fujino, T., Tsutsui, K. et al. (2001) The tumor-preventing effect of a mixture of several lactic acid bacteria on 1,2-dimethylhydrazine-induced colon carcinogenesis in mice. Oncol. Rep., 8, 1073-1078. 

With XA1PcS3, selective photonecrosis of colonic tumors induced with dimethylhydrazine was observed with low drug doses (0.5 mg kg-1), but selectivity over normal tissue disappeared at 5 mg kg-1.329 The use of this material (in the form of PHOTOSENS as a mixture of di- and tri-sulfonic acids (7)) in extensive clinical treatments in Moscow has been referred to in Section 9.22.4. 

Nauss, K.M., Locniskar. M., Pavlina, T. Newbeme, PM. (1984) Morphology and distribution of 1,2-dimethylhydrazine dihydrochloride-induced colon tumors and their relationship to gut-associated lymphoid tissue in the rat. J. natl Cancer Inst., 73, 915-924... 

Dimethylhydrazine (DMFI)-induced rat colon carcinogenesis model was used for evaluation of the synergistic inhibitory effect between curcumin and catechin in light of ACF formation and tumor incidence. The results of this... 

A series of studies show that sphingolipids derived from milk protect against development of colon tumors in mice. In the initial study (Dillehay et al., 1994), mice fed diets supplemented with 0.025, 0.050 or 0.1% sphingomyelin had less than half the incidence of 1,2-dimethylhydrazine (DMH)-induced colon tumors than mice fed non-supplemented diets. In addition, a diet supplemented with 0.025% of the ganglioside GMj produced significantly fewer DMH-induced aberrant crypt foci (ACF) than control animals. ACF are microscopically determined pre-neoplastic lesions that can develop into colon tumors. 

Turusov VS. 1980. Morphology and histogenesis of anal region and clitoral gland tumors induced in mice by 1,2-dimethylhydrazine. J Natl Cancer Inst 5 1161-1167. 

Various organic sulfides present in Allium have been found to have anticar-cinogenic activity. For example, allyl sulfide, a constituent of garlic oil, inhibited colon cancer in mice exposed to 1,2-dimethylhydrazine, and allyl methyl trisulfide, allyl methyl disulfide, aUyl trisulfide, and allyl sulfide all inhibited benzo[a]pyrene-induced neoplasma of the forestomach and lung in female mice (55). Lam et al. (Chapter 22) investigated the ability of 2-n-butyl thiophene, a constituent of roast beef aroma, to inhibit chemically induced carcinogenesis in three different tumor systems. This compound was found to be effective in the forestomach, lung, and colon models. 

It has been shown that CLA was able to protect against 2-amino-3-methylimida-zo[4,5-/]quinoline-induced colon carcinogenesis in F344 rats (25). A recent study (26) demonstrated that 1% dietary CLA significantly decreased colon tumor incidence in the colon of 1,2-dimethylhydrazine (DMH)-treated rats, and the apoptotic index estimated by the terminal deoxynucleotidyl transferase-mediated dUTP nick... 

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