Directly acting

Guaiacols. Cresote, obtained from the pyrolysis of beechwood, and its active principles guaiacol [90-05-1] (1) and cresol [93-51-6] (2) have long been used ia expectorant mixtures. The compounds are usually classed as direct-acting or stimulant expectorants, but their mechanisms of action have not been well studied. Cresol is obtained by the Clemmensen reduction of vanillin (3), whereas guaiacol can be prepared by a number of methods including the mercuric oxide oxidation of lignin (qv) (4), the ziac chloride reduction of acetovanillone (5), and the diazotization and hydrolysis of o-anisidine (6). 

Dupl ex Double-Acting Pumps These pumps differ primarily from those of the simplex type in having two cyhnders whose operation is coordinated. They may be direct-acting, steam-driven, or power-driven with crank and flywheel. 

Control-System Components The three principal elements of a control system are the sensing device which measures the error as the deviation from the set point, means for transmission and amphfi-cation of the error signal, and the control output device in the form of a seivo-operated valve. In the case of the direct-acting flyball governor (Fig. 29-18) these three elements are combined in the flyball element and the linkage that connects to the valve. 

M to 9 Direct acting indicating analogue electrical measuring instruments and their accessories 1248 1 to 9 BS 89-1 to 9 ... 

Direct acting recording electrical measuring instrument and their accessories - BS 90/1993 -... 

Figure 3-69. Horizontal direct-acting steam pump or power pump.

Figure 12-31. Capacity control suction valve unloaders are available in either of two designs with pneumatic operators (A) direct-acting (air to unload) (B) reverse-acting or fail safe (air to load), which automatically unloads the compressor in the event of control air failure (C) an innovation in manually operated unloaders. Here, the lever cam arrangement provides positive loading or unloading, eliminating the requirement to turn a handwheel completely in or out. (Used by permission Bui. 9-201B, 1991. Cooper-Cameron Corporation.)...

Many of these devices are direct acting on the controlled device and do not require a controller to process the signal. 

Proportional detectors measure the process condition, which can then he compared hy the controller with the required value. They are not direct acting, and need a controller to convert the signal to a working instruction to the controlled device. Proportional detectors include ... 

The cholinesterase inhibitors are more potent and longer acting tiian the direct-acting miotics and are used... 

Some laboratory studies with rats and mice have linked trichloroethylene exposure to various types of cancers. Several of these studies, however, should be viewed cautiously, since the tumorigenic activity might be influenced by the presence of direct-acting compounds, namely the epoxides (e.g., epichlorohydrin) added as stabilizers in trichloroethylene. Epoxides are known to be very reactive, and some, such as epichlorohydrin, are potent carcinogens themselves. 

Figure 7.7 Dopamine-induced rotation in the rat in which one (left) nigrostriatal dopamine pathway from the substantia nigra (SN) to the caudate putamen (CP) has been lesioned by a prior injection (14 days) of 6-hydroxydopamine. Amphetamine, an indirectly acting amine, releases DA and so can only act on the right side. Since the animal moves away from the dominating active side it induces ipsilateral rotation (i.e. towards the lesioned side). By contrast, the development of postS5maptic supersensitivity to DA on the lesioned side ensures that apomorphine, a directly acting agonist, is actually more active on that side and so the animal turns away from it (contralateral rotation)...

The above scheme satisfies much of the metabolic data however, some of it is speculative, and it is certainly incomplete. The evidence for the formation of the a-hydroxylated intermediate is circumstantial. The acetate ester of a-hydroxylated dimethylnitrosamine has been prepared (12.13) and has been found to be a potent, directly acting carcinogen (14). Other esters of a variety of a-hydroxylated nitros-amines have also been prepared (15). While it has been shown that DMN acetate is hydrolyzed to hydroxymethylmethyl-nitrosamine by an esterase enzyme, it has been pointed out that these derivatives of the a-hydroxylated nitrosamines also dissociate to N-nitrosoimmonium ions (15 16). 

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