Diabetes sweeteners

In a similar way, xylitol, maltitol and lactitol are obtained from xylose, maltose and lactose. These sugar alcohols are used as low calory or diabetic sweetener. They are claimed to be non-cario-genic. 

Saccharin. Sacchatin [81-07-2] C H NO S, which is approximately 300 times as sweet as sucrose ia coaceatratioas up to the equivaleat of a 10% sucrose solutioa, has beea used commercially as a nonnutritive sweeteaer siace before 1900, predomiaanfly ia carboaated soft drioks, tabletop sweeteaers, and dietetic foods marketed primarily to diabetics. In 1977, the FDA proposed a ban on sacchatin because of its association with bladder cancer ia laboratory animals. At the time, it was the only commercially available nonnutritive sweetener, and pubflc outcry led to a delay of the ban, which was officially withdrawn ia 1991. Instead, the FDA required that warning labels be placed on all foods that contained the iagredient. Although sacchatin is heat stable, the pubflc debate over its safety, as well as the fact that approximately one-third of the population perceives it to have a bitter aftertaste, has limited its use. 

Early applications of crystalline fructose focused on foods for special dietary applications, primarily calorie reduction and diabetes control. The latter application sought to capitalize on a signiftcandy lower serum glucose level and insulin response in subjects with noninsulin-dependent diabetes melUtus (21,22) and insulin-dependent diabetes (23). However, because fmctose is a nutritive sweetener and because dietary fmctose conversion to glucose in the hver requires insulin in the same way as dietary glucose or sucrose, recommendations for its use are the same as for other nutritive sugars (24). Review of the health effects of dietary fmctose is available (25). 

Sorbitol is a sweetener often substituted for cane sugar, because it is better tolerated by diabetics. It is also an intermediate in the commercial synthesis of vitamin C. Sorbitol is prepared by high-pressure hydrogenation of glucose over a nickel catalyst. What is the structure (including stereochemistry) of sorbitol ... 

Odier dragp are taken 1 hour before or 4 to 6 hours after cholestyramine Cholestyramine is available combined widi die artificial sweetener, aspartame (Questran Light), for patients widi diabetes or diose who are concerned with weight gain. 

FDA Approves New High-Intensity Sweetener Sucralose. FDA Talk Paper T98-16, April 1,1998, The Diabetes Monitor, http //www.diabetesmonitor.com/sucralos.htm... 

Negative public reaction to the FDA ban. Consumers tried to stock up saccharin products against the coming ban diabetics lobbied Congress to reverse the ban (no other nonsugar sweetener available at that time) consumers asked for a warning label on the product instead... 

Sweetness free, or at least virtually free, from calories establishes the need for intense sweeteners while suitability for diabetics, absence of carcinogenicity with functionality similar to sucrose and related carbohydrates form the basis for application of bulk sweeteners. 

Metabolism via normal metabolic pathways or fast excretion without metabolism are desirable characteristics. Some intense sweeteners are excreted unchanged while others are metabolised. Bulk sweetener absorption is lower and slower than for carbohydrates and results in reduced caloric availability which is partly due to metabolites formed by intestinal bacteria. Such metabolites and osmotic effects of not fully absorbed bulk sweeteners can cause laxative effects. Generally, the calorific value of bulk sweeteners is lower than for carbohydrates. Intense and bulk sweeteners are, as far as they are metabolised, not dependent on insulin. They are therefore acceptable for diabetics as part of a suitable diet. 

The design of safe sweeteners is very important for people who are afiected by diabetes, hyperlipemia, caries and other diseases that are linked to sugar consumption. Sweet proteins, which are found in several tropical plants, are many times (100-100,000) sweeter than sucrose on a molar basis. Only a few sweet proteins are known miraculin, monellin, thaumatin, curculin, mabinlin. 

Food additives such as preservatives, sweetening agents, flavours, antioxidants, edible colours and nutritional supplements are added to the food to make It attractive, palatable and add nutritive value. Preservatives are added to the food to prevent spoilage due to microbial growth. Artificial sweeteners are used by those who need to check the calorie Intake or are diabetic and want to avoid taking sucrose. 

Name the sweetening agent used in the preparation of sweets for a diabetic patient. 

On the other hand, borohydride reduction of the ketose o-fructose will give a mixture of o-glucitol and its epimer, D-mannitol. A better approach to D-mannitol would be reduction of the aldose D-mannose. o-Glucitol (sorbitol) is found naturally in the ripe berries of the mountain ash (Sorbus aucuparia), but is prepared semi-synthetically from glucose. It is half as sweet as sucrose, is not absorbed orally, and is not readily metabolized in the body. It finds particular use as a sweetener for diabetic products. o-Mannitol also occurs naturally in manna, the exudate of the manna ash Fraxinus ornus. This material has similar characteristics to sorbitol, but is used principally as a diuretic. It is injected intravenously, is eliminated rapidly into the urine, and removes fluid by an osmotic effect. 

Every patient with diabetes requires some form of dietary assessment, and often therapy. This is important to allocate the relative amounts of energy derived from carbohydrate, protein and fat of total recommended daily calories in proportion to the patient s body weight and height and daily requirements, while avoiding atherogenic diets. Diets with high carbohydrate content (50-60%), low fat (30-35%) and adequate protein (10-15%) is recommended. Fibre-rich foods are preferable. The use of non-nutritive sweeteners (saccharin, aspartame, ace-sulfame K and sucralose) are acceptable. Alcohol intake should be assessed since excess consumption... 

Artificial sweeteners such as sorbitol saccharin is used as synthetic sweetening agent which is more palatable having no food value and can be used by diabetic patients. 

Fructose, another common monosaccharide found in fruits and honey, is more soluble in water than glucose and is also sweeter than glucose. It is used as a sweetener for diabetic patients, and in infusion for parenteral nutrition. 

Lactose has a sweetish taste, and is used extensively in the pharmaceutical industry. It is the second most widely used compound and is employed as a diluent, filler or binder in tablets, capsules and other oral product forms, a-lactose is used for the production of lactitol, which is present in diabetic products, low calorie sweeteners and slimming products. As lactose is only 30 per cent as sweet as sugar it is used as a sugar supplement, and also in food and confectionery. It is used in infant milk formulas. 

In recent years the consumption of carbohydrates in the form of refined sugar has received significant attention from health professionals. The annual consumption of sugar in the United States is about 50 pounds per person or just under 1 pound per week. The adverse effects of excessive sugar in the diet include obesity, increased risk of heart disease, diabetes, tooth decay, and disruptive behavior such as hyperactivity in children. Because of these problems, the food industry has used a number of synthetic or artificial sweeteners in place of sugar. These artificial sweeteners may reduce the use of sugars, but they have also been... 

Typically, the concentration of sweeteners in oral solutions or suspensions averages between 30% and 50% of the formulation. In fact, in some cough or cold syrups, the sweetener content is as high as 80%. However, because of a growing population of diabetic patients in the United States, it is advisable to keep the amount of added sweetener (sucrose) as low as possible. Additionally, when natural sweeteners are used, there is an increase risk of microbial contamination and growth in the liquid formulation. 

Sweetness is one of the most important taste sensations for humans. Sucrose has been widely used for its sweetness as well as for functional properties such as texture, mouthfeel, bulking agent, and preservative. However, the specialized dietary requirements of diabetics and health concerns about obesity and dental caries have prompted a considerable research effort into the development of alternative sweeteners (1-6). 

---