Cytogen

Physicochemical properties requked include melting/boiling point, vapor pressure, solubiUty, and flammabiUty/explosion characteristics. The toxicological studies include acute toxicity tests, oral, inhalation, and dermal skin and eye kritation skin sensiti2ation subacute toxicity, oral, inhalation, and dermal and mutagenicity tests. In vitro reverse mutation assay (Ames test) on Salmonella typhimurium and/or E.scherichia coli and mammalian cytogenic test. In vivo mouse micronucleus test. [Pg.301]

Ethylene oxide has been shown to produce mutagenic and cytogenic effects in a variety of test systems (226). An increased frequency of chromosomal aberrations in peripheral lymphocytes of monkey exposed to ethylene oxide for 104 weeks has been reported (240). In mice, it is an effective inducer of chromosome breaks leading to dominant-lethal mutations. In addition, ethylene oxide has been shown to induce heritable effects in the heritable translocation test conducted in mice exposed to ethylene oxide by inhalation (241,242). In this study, male mice were exposed to ethylene oxide ranging from 165 to 300 ppm for 6 h per day 5 or 7 days/week for 8.5 weeks. Ethylene oxide has also been shown to bind to proteins (243) as well as to DNA (244). Several studies on ethylene oxide-exposed workers have demonstrated an increased incidence of chromosomal aberrations and sister chromatid exchanges the relevance of such effects to human health evaluation is currendy uncertain. [Pg.464]

De Ferrari M, Artuso M, Bonassi S, et al. 1991. Cytogenic biomonitoring of an Italian population exposed to pesticides Chromosome aberration and sister-chromatid exchange analysis in peripheral blood lymphocytes. Mutat Res 260 105-113. [Pg.201]

Sarto F, Stella M, Acqua A. 1978. [Cytogenic studies in 20 workers occupationally exposed to lead.] Med Lav 69 172-180. (Italian)... [Pg.571]

Schmid E, Bauchinger M, Pietruck S, et al. 1972. [Cytogenic action of lead in human peripheral lymphocytes in vitro and in vivo. Mut Res 16 401-406. (German)... [Pg.572]

Tachi K, Nishimae S, Saito K. 1985. Cytogenic effects of lead acetate on rat bone marrow cells. Arch Environ Health 40 144-147. [Pg.579]

No information on genotoxicity in humans was located. In vitro, a cytogenic assay with human lymphocytes was negative (Collins et al. 1995). Vapor concentrations ranged from 5% to 100% volume per volume (v/v), and the incubation period was 3 h in both the presence and absence of metabolic activation. [Pg.145]

Some modifications to current in vivo testing methods both can and should be adopted. A current example of this would be in medical devices where a substantial portion of the requirements under the governing regulatory (ISO 10993) can be met with in vitro alternatives (cytogenicity, muscle cell implantation, the limulus test for pyrogens, and in vitro mutagenicity assays). [Pg.648]

Conventional cytogenic analysis is performed on a small sample of heparinized blood. Phytohemagglutinin is added to induce mitotic division. After 65 to 72 hours in culture, colchicine is added, which by preventing spindle... [Pg.22]

Richler, C., Dhara, S.K., and Wahrman, J. (2000) Histone macroH2A1.2 is concentrated in the XY compartment of mammalian male meiotic nuclei. Cytogene. Cell Genet. 89, 118-120. [Pg.202]

Benz RD, Beltz PA. 1980. Cytogenic toxicologic testing with dogs. Environ Mutagen 2 312-313. [Pg.167]

Ethyl 2-ethylthio-4-chloro-5-pyrimidinecarboxylate (XXIIa), as well as the corresponding4-hydroxy-(XXIIb) and 4-amino-(XXIIIa) derivatives, possess-anti-cytogenic activity on Neurospora crassa [223, 224]. Compounds (XXIIIa, b and c) were found to inhibit the conversion of orotic acid to the uridine nucleotides [202]. Ethyl 2-methylthio-4-(halo-substituted anilino)-5-pyrimidinecarboxylates (XXIV), particularly the o-bromo- and the o-chloro- derivatives, substantially inhibit the growth of five experimental mouse tumours (Krebs-2 ascites carcinoma, Ehrlich carcinoma clone 2, leukaemia L-1210, carcinoma 755 and lymphocytic neoplasm P-288) [225]. Compounds of this type are usually prepared by the base catalysed condensation of ethoxymethylenemalonic esters or related derivatives with urea, thiourea, guanidine, or substituted amidine-type analogues [212, 225-237]. [Pg.294]

There are no indications of mutagenic or cytogenic effects for -butyl acetate. ... [Pg.98]

Sawada M, Sofuni T and Ishidate M Jr Cytogenic effects of 1,1-dichloroethylene in mammalian cells (II). MutatRes 130 380 (abst), 1984... [Pg.146]

Kligerman AD, Morgan DL, Doerr CL, et al Cytogenic effects in mice of divinylbenzene-55 inhalation. Mutat Res 370(2) 107-113, 1996... [Pg.290]

Picciano D Cytogenic investigation of occupational exposure to epichlorohydrin. Mutat Res 66 169-173, 1979... [Pg.295]

Because EEA is well absorbed through the skin, ambient monitoring of environmental exposure levels is not considered to be an accurate method of determining absorbed dose. Biological monitoring of the EEA metabolite 2-ethoxyacetic acid in urine has been shown to be an effective indicator of absorbed dose in workers. " Cytogenic examination of persons exposed to EEA did not show an increase in sister chromatid exchanges or in micronuclei. "... [Pg.305]

In genotoxic assays both positive and negative results have been reported. A cytogenic study of 35 patients admitted to the hospital after exposure to MIC at Bhopal found no significant effects on sister chromatid exchanges, chromosomal aberrations, or cell cycle. Other studies have found chromosomal abnormalities (especially translocations) in exposed individuals. ... [Pg.486]

Lakkad BC, Karnik AB, Shishir N, et al Cytogenic evaluation of persons exposed to methyl isocyanate at Bhopal. Indian find Med 42(4) 203-205, 1996... [Pg.486]

Stodddard solvent was not genotoxic in a variety of assays including Salmonella typhimurium, a mouse lymphoma mutation assay, rodent bone marrow cytogenic tests, and rodent dominant lethal tests." ... [Pg.639]

Nikiforov A, Slozina N, Neronova E, et al Cytogenic investigation of thallium-poisoned people Pilot study. J Toxicol Environ Health A 58(8) 465-8, 1999... [Pg.670]

OncoScint CR/OV (Satumomab Cytogen Pendetide, murine Mab directed against TAG-72, a high molecular weight tumour-associated glycoprotein)... [Pg.505]

Waksvik H, Boysen M. 1982. Cytogenic analysis of lymphocytes from workers in a nickel refinery. Mutat Res 103 185-190. [Pg.255]

LFTs before treatment and every month, CBC, serum chemistry, bone marrow assessment (including cytogenic analysis)... [Pg.614]

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