Human Health Evaluation

Ethylene oxide has been shown to produce mutagenic and cytogenic effects in a variety of test systems (226). An increased frequency of chromosomal aberrations in peripheral lymphocytes of monkey exposed to ethylene oxide for 104 weeks has been reported (240). In mice, it is an effective inducer of chromosome breaks leading to dominant-lethal mutations. In addition, ethylene oxide has been shown to induce heritable effects in the heritable translocation test conducted in mice exposed to ethylene oxide by inhalation (241,242). In this study, male mice were exposed to ethylene oxide ranging from 165 to 300 ppm for 6 h per day 5 or 7 days/week for 8.5 weeks. Ethylene oxide has also been shown to bind to proteins (243) as well as to DNA (244). Several studies on ethylene oxide-exposed workers have demonstrated an increased incidence of chromosomal aberrations and sister chromatid exchanges the relevance of such effects to human health evaluation is currendy uncertain. 

EPA (1989) Risk Assessment Guidance for Superfund. Volume I. Human Health Evaluation Manual. EPA/540/1-89/002. 

U S Environmental Protection Agency. Risk Assessment Guidance for Superfund (RAGS), Vol. I Human Health Evaluation Manual (Part E, Supplemental Guidancefor Dermal Risk Assessment) Interim, 2004 http //www.epa.gov/oswer/ riskassessment/ragse/index.htm (last accessed 12 July 2010). 

USEPA] US Environmental Protection Agency. 1989. Risk assessment guidance for superfund. I. Human health evaluation manual (Part A). Technical report EPA 540-1-89-002 Washington (DC) Office of Emergency and Remedial Response, USEPA. 

US Environmental Protection Agency (US EPA) (2009). Risk assessment guidance for Superfund (RA65), volume 1 Human health evaluation manual (Part F Supplemental guidance for inhalation risk assessment). Office of Research and Development, Washington, DC. 

Risk Assessment Guidance for Superfund Human Health Evaluation Manual Part A. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response Washington, DC 20460. OSWER Directive 9285.701a, July, 1989. 

D.J. Vorhees, W. H. Weisman and J. B. Gustafson, Total Petroleum Hydrocarbon Criteria Working Group Volume 5 Human Health Evaluation of Petroleum Release Sites. Implementing the Working Group Approach, Amherst Scientific Publishers, Amherst, 1999. 

EPA Risk Assessment Guidance for Superfund Volume 1 Human Health Evaluation Manual (Part B, Development of Risk-Based Preliminary Remediation Goals. (1991a). Publication 9285.7-OlB. Washington, DC Office of Emergency and Remedial Response, NTIS PB92-963333. 

Mozaffarian, D. E.B. Rimm. Fish intake, contaminants, and human health Evaluating the risks and the benefits./. Amer. Med. Assoc. 2006,296, 1885—1899. 

The Department of Defense Appropriation Act of 2002 required the DOD to establish a program and protocol for the prioritization of sites containing munitions and explosives of concern (MEC), releases of hazardous substances, and CWM. Each of these aspects has a distinct scoring module within the Munitions Response Site Prioritization Protocol (MRSPP). These are titled the Explosives Hazard Evaluation (EHE), the Human Health Evaluation (HHE), and the Chemical Hazard Evaluation (CHE), respectively. The MRSPP was finalized through federal rulemaking on October 5,2005, under 32 CFR Part 179. Additional information on the prioritization protocol can be found onUne at http //www.denix.osd.mil. 

HHE Health Hazard Evaluation or Human Health Evaluation... 

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