Ehrlich carcinoma

Burlaka et al. (2004) used pristine C60 at 10 pM with visible light from a mercury lamp to produce some phototoxicity in Ehrlich carcinoma cells or rat thymocytes and used EPR spin-trapping techniques to demonstrate the formation of ROS. 

Ethyl 2-ethylthio-4-chloro-5-pyrimidinecarboxylate (XXIIa), as well as the corresponding4-hydroxy-(XXIIb) and 4-amino-(XXIIIa) derivatives, possess-anti-cytogenic activity on Neurospora crassa [223, 224]. Compounds (XXIIIa, b and c) were found to inhibit the conversion of orotic acid to the uridine nucleotides [202]. Ethyl 2-methylthio-4-(halo-substituted anilino)-5-pyrimidinecarboxylates (XXIV), particularly the o-bromo- and the o-chloro- derivatives, substantially inhibit the growth of five experimental mouse tumours (Krebs-2 ascites carcinoma, Ehrlich carcinoma clone 2, leukaemia L-1210, carcinoma 755 and lymphocytic neoplasm P-288) [225]. Compounds of this type are usually prepared by the base catalysed condensation of ethoxymethylenemalonic esters or related derivatives with urea, thiourea, guanidine, or substituted amidine-type analogues [212, 225-237]. 

Inorganic and organic selenium have been reported to loca ze in several types of human tumors (62, 63) Uptake of both Se selenate and selenite were similar (64) Ehrlich carcinoma,... 

The effect of tocotrienols on cancer progression was evaluated by Komi-yama and Yamaoka (177). The antitumor activity of tocotrienols was evaluated in terms of the increase in the lifespan of mice inoculated with tumor cells. a-Tocotrienols and y-tocotrienols were effective against the sarcoma cancer cell lines and Ehrlich carcinoma. When human lung carcinomas were challenged with these tocotrienols, a cytotoxic activity due to the tocotrienols was exhibited. Similarly. DMBA-treated rats responded with lower tumor numbers when their diets were supplemented with palm tocotrienols (178). Recently, a-carotene isolated from pahn oil has been shown to have antitumor activity against mouse lung cancer and against skin cancer (179). 

Dihydrodidemnin (DDB) is a depsipeptide that has been isolated from Aplidium albicans (Mediterranean tumicates). DDB was studied on Ehrlich carcinoma growing in vivo and in primary cells [112] and found to behave as a very potent inhibitor of protein synthesis. 

Two new diterpenic glycosides, virescenosides M 9 and N 10, were isolated from the marine fungus Acremonium striatisporum KMM 4401 which was associated with the holothurian Eupentacta fraudatrix. They both exhibited cytotoxic action against tumor cells of Ehrlich carcinoma in vitro, and showed a cytotoxic effect on developing eggs of the sea urchin Strongylocentrotus intermedius. 

Serratia marcescens polysaccharide has been reported to be active against a number of other tumors, such as Sarcoma 180 (Ref. 22), Ehrlich carcinoma,22 Guerin carcinoma,23 Sarcoma M-l (Ref. 23), and Walker carcinosarcoma.24 Navashin and coworkers25 found that... 

Effect of Proteus vulgaris Lipopolysaccharide on Solid Ehrlich Carcinoma and5 Sarcoma 180... 

Polysaccharides may be active components in undefined aqueous extracts (from sonicated E. coli) which inhibited ascites tumors, such as Sarcoma 180, Ehrlich carcinoma, and MM2 in ddD mice.70 Likewise, polysaccharides may be implicated in the activity of heat-killed Corynebacterium parvum against tumors in mice.71-73... 

Gum arabic prevented tumor takes if animals were treated with gum arabic before tumor implantation.158,157 Bamboo polysaccharide was quite effective in preventing tumor takes when given in-traperitoneally, starting 10 days before s.c. tumor implantation of Ehrlich carcinoma. Starch and degraded starches ( dextrins ) had no inhibitory effect.157... 

Luxemburgia nobilis Eichl. (leaves) Ochnaflavone (I-3, 0,II-4 —flavone-flavanone)-. 11-2,3-Dihydroochnaflavone (225). Inhibitor of DNA topoisomerases. (225) was cytotoxic to murine Ehrlich carcinoma and human leukemia K562 cells. (225) inhibited the activity of human DNA topoisomerases I and Il-a. (225) is a DNA interacting agent, which causes DNA unwinding in an assay with topoisomerase I. Likhitwitayawuid e al., 2001 [290] D Oliveira et al 2002[291],2005[59]. 

Ouratea semiserrata Mart (Engl.) (leaves and branches) Biflavones. I-7-O-Methyllanaroflavone (250) 1-7,11-4 -di-O-methyllanaroflavone (251) lanaroflavone (249) amentoflavone (1) podocarpusflavone A (6). Amentoflavone and its aeetyl derivative are inhibitors of human DNA topoisomerases 1 at 200 pM. These biflavonoids showed concentration-dependent growth inhibitory activities on Ehrlich carcinoma cells in 45-h culture. These biflavonoids are targets for DNA topoisomerases and their cytotoxicity is dependent on tumor cell type. Lanaroflavone is an active antiplasmodial compound Velandia et al., 2002[313] Grynber g et al., 2002[48] Weniger et al., 2006[86]. 

Methylagathisflavone (7"-0-methylagathisflavone) (103) and amentoflavone (1) showed concentration-dependent growth inhibitory activities on Ehrlich carcinoma cells in 45-h culture, tested by the tetrazolium method, with 1C50=24 1 gM for 103, and 26 1 gM for l. [48]... 

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