Contact dermatitis ointment causing

Systemic contact dermatitis is a delayed hypersensitivity skin reaction that results from systemic exposure. Exanthematous systemic contact dermatitis from ethylenediamine has been reported with aminophylline. Disodium edetate (ethylenediamine tetra-acetic acid) has caused contact dermatitis after local application (SEDA-23, 242), and ethylenediamine cross-reacted in a patch test in a patient who had had contact dermatitis with hydroxyzine, an ethylenediamine derivative (SEDA-22, 178). Prior sensitization can occur to ethylenediamine in creams and ointments (SED-14, 485). 

Mupirocin ointment can occasionally cause allergic contact dermatitis (3). 

Parabens can cause allergic contact dermatitis that can run an insidious course, especially when the parabens are in glucocorticoid ointments. In such cases, treatment leads to a protracted dermatitis without acute exacerbation, so that neither the patient nor the physician suspects parabens as a possible cause. A sensitization index of 0.8% was found in 273 patients with chronic dermatitis (1). 

Mechlorethamine hydrochloride (Mustargen) and carmustine (bischloronitrosourea, BCNU, BICNU) are used topically to treat cutaneous T-cell lymphoma. Both can be applied as a solution or in ointment form. It is important to monitor complete blood counts and liver function tests because systemic absorption can cause bone marrow suppression and hepatitis. Other side effects include allergic contact dermatitis, irritant dermatitis, secondary cutaneous malignancies, and pigmentary changes. Carmustine also can cause erythema and posttreatment telangiectasias. 

Falicain allergy reported in 28 of 70,000 dermatologic patients was mainly caused by hemorrhoidal ointments and suppositories (Scholz and Richter 1977). It caused several cases of allergic contact dermatitis in East Germany (Behrbohm and Lenzner 1975). 

Crotamiton (Eurax) is used as a scabicide and is antipruritic. It caused contact dermatitis in a patient with stasis dermatitis treated with Eurax ointment (van Duk and Marien 1972). It has not sensitized in short-term exposure such as in scabies therapy. 

Oxypolyethoxydodecane, a derivative of alkyl polyethylene used as antipruritic agent in Anacal rectal ointment, caused perianal allergic contact dermatitis in a woman (Calnan 1978). 

Coumarin (coumarinic anhydride) and drivatives are added as a fragrance to topical preparations. Allergic contact dermatitis from coumarin derivatives was seen in a patient who had applied Jecovitol ointment to a foot ulcer (Van Ketel 1973). The synthetic 6-methylcoumarin has caused allergic photocontact dermatitis (Kaidby and Kligman 1978). 

Nitroglycerin ointment applied frequently over large body areas in angina pectoris patients has caused allergic contact dermatitis (Hendricks and Dee 1979 Sausker and Frederick 1978). Sensitization developed even after previous peroral use of the drug. 

Penicillin is a potent topical sensitizer and may cause contact dermatitis (Levine 1960 a Fellner 1976) it is therefore no longer used in ointments. Several other cutaneous manifestations of penicillin allergy, such as fixed drug eruption, erythema multiforme, the Stevens-Johnson syndrome, exfoliative dermatitis, epidermal necrolysis, erythema nodosum and cutaneous necrotizing angiitis have been described (Fellner 1976 Soter and Austen 1978 Wintraub et al. 1979 De Swar-TE 1972). The precise immunological mechanisms of these various forms of cutaneous reactions are usually not known. 

Bronchial asthma has been described in a mother who had opened capsules of pancreatic extract, which had been prescribed for her children suffering from cystic fibrosis (Sakula 1977). Piperazine is an anthelmintic drug. Single cases of angioedema, urticaria, exanthema, and erythema multiforme have been reported in Sweden. Suppositories and ointments used for the anal region can cause allergic contact dermatitis. Procaine, benzocaine, cinchocaine, and antimicrobial agents are the most common offenders. We have seen two cases of purpura and one case of urticaria caused by such suppositories. 

Four cases of proved allergic contact dermatitis caused by idoxuridine after application to the eye and skin for ophthalmic and genital herpes simplex infections were reported by Amon et al. (48 ). Patch tests were performed with 0.5%, 1% and 5% idoxuridine in a proprietary ointment base or dimethylacetamide. Cross reactions to brom-inated and chlorinated (but not to fluorin-ated) pyrimidine analogues could be noted. 

Other adverse reactions that have been reported include exfoliative dermatitis due to ointments that contain sorbic acid, and allergic conjunctivitis caused by contact lens solutions preserved with sorbic acid. ... 

It is sometimes recommended that persons subject to allergy should not be allowed to come in contact with epoxy resin systems. This would be an improbably measure to observe, it must be kept in mind that exposure to epoxy resin systems cannot cause anything but skin dermatitis. There has been absolutely no evidence of any carcinogenic effect from contact with these systems. Where slight irritations occur, desensitization should first be attempted. If eczema occurs, standard medical treatment should be provided. Antihistamine drugs may be used only to reduce itching. In severe cases, such as in the second stage of dermatosis, cortisone ointments have been used successfully to relieve the symptoms. It should be kept in mind that if protective measures are scrupulously observed, incidents of dermatoses from epoxy resin systems can be kept to a very low minimum. There is no reason for any concern in the use of these systems in the construction industry. 

Cirmamaldehyde can cause dermatitis in humans and allergic reactions have occurred from contact with products (foods, toothpastes, ointments, mouthwashes) containing either cirmamaldehyde or cirmamon oil (de smet et al.). Cirmamon may cause allergic reactions in some people who are allergic to balsam of Pem. Cassia oil causes mucous... 

---