1,2-ethylenediamine derivative

A kind of modification of the Polonovski-Boon synthesis is the reaction of 5,6-dihalopyrimidines with ethylenediamine derivatives. Depending on the bulkiness of the amino substituents a more or less regiospecific condensation may proceed (71CB780), as shown recently in the reaction of 5-bromo-6-chloro-l,3-dimethyluracil (279) with 2-methyl-amino- -propylamine to form l,3,5,6-tetramethyl-5,6,7,8-tetrahydrolumazine (280 equation 99) (80Ba3385). 

The ethylenediamine derivative [31] possesses higher promoting activities than other diamines. This phenomenon may be ascribed to the copromoting effect of the two amino groups on the decomposition of persulfate through a CCT (contact charge transfer complex) formation. So we proposed the initiation mechanism via CCT as the intimate ion pair and deprotonation via CTS (cyclic transition state) as follows ... 

Ethylenediamine derivative of Hercosett Scheme 10.64 About 95% fixation of low- or high-reactivity dyes under slightly acidic conditions without salt, but light fastness still inferior... 

In a study of ethoxylated ethylenediamine derivatives (12.4) in the application of acid dyes to nylon, covering a range of ethoxylation from 40 to 180 units per molecule (average... 

A nickel(II) species is also though to be an intermediate in the carbonyla-tion reaction of iodobenzene with (V-methylbenzaldimine and nickel carbonyl. Two addition modes of an ensuing aroylnickel(II) complex to the C=N double bond can be envisaged as routes to l-methyl-2-phenylindol-3-one and an ethylenediamine derivative (Scheme 47).7 5 The scope of this simple indole synthesis has not been assessed. 

Imidazole nitrones 127 reacted with dimethyl acetylenedicarboxylate to yield imidazo[l,5-fc]isoxazoles 128, which in the presence of base afforded imidazoles 129 <00TL5407>. Chiral imidazoline nitrone 130 participated in a [3+2] cycloaddition reaction with various dienophiles to furnish imidazoisoxazoles 131 <00SL967>. A convenient synthesis of AyvyV -trisubstituted ethylenediamine derivatives from 2-methyl-2-imidazoline has been reported <00SC3307>. Dehydrogenation of 1,3-di- and 1,2,3-trisubstituted imidazolidines afforded l//-4,5-dihydroimidazolium salts <00SC3369>... 

Hj histamine receptor blockers can be grouped according to their chemical structures ethanolamine derivatives (diphenhydramine, clemastine) ethylenediamine derivatives (tripe-lennamine, pyrilamine) alkylamines (chloropheniramine, dexchlorpheniramine, brompheniramine) piperazines (cycUzine, meclizine, hydroxizine) phenothiazines (promethazine, trimeprazine) piperidines (cyproheptadine, diphenylpyraline) and others that do not belong to a specific chemical classification (terfenadine, astemizole). 

By the reaction of Cjq with secondary diamines, dehydrogenated 1,2-diamino-cycloadducts and polyadducts have been isolated. Isomerically pure monoadducts were obtained by the reaction of secondary diamines, for example N,N -dimethyl-ethylenediamine, piperazine, homopiperazine [81], N-ethylethylenediamine and further ethylenediamine derivatives [80], with Cgo between 0 and 110 °C (Figure 3.9) [80,81]. In dilute solutions of the reactants, mono- and bisadducts are predominantly formed even if a large excess of the diamine is used. 

Chemical Class Ethylenediamine derivative Clinical Pharmacology ... 

Octammino-diol-dichromic Salts, [Cr2(NH3)8(OH)2]R4.—These salts correspond to the ethylenediamine derivatives described above, and are prepared in the same manner. Dubsky, in an attempt to ascertain the constitution of the diol salts, prepared a number of salts belonging to the series. Octammino-diol-dichromic sulphate is formed when hydroxo-aquo-tetrammino-chromic sulphate is heated with excess... 

A series of new nitramines, the ethylenediamine derivatives, was prepared by Picard and Meen [24] by the action of acetone cyanohydrin on ethylenediamine and its analogues (i.e. diethylenetriamine etc.), followed by the nitration of the products... 

Several polydentate SBs may act as binucleating ligands see Section 33.5.12.1. Only a few miscellaneous polydentate SBs will be included here. A complex with the SB obtained in the reaction of two moles of benzoyl hydrazide with acetylacetone had v(V=0) = 995 cm 1, Pea =1.7BM and was monomeric square pyramidal (117).792 A few complexes with the ethylenediamine derivatives of 2,2 -dihydroxychalcones (118) were prepared in ethanol.793 The stoichiometry is 1 1 and the atoms involved in the coordination were two deprotonated oxygens and two nitrogen atoms. v(V—O) (970-985 cm-1) and f4 (1.73-1.83 BM) suggest a monomer however, molecular weights in nitrobenzene suggest a dimer. 

Further digging in the literature led us to focus on the simplest, ethylenediamine-derived Co(salen), 18, which used catalytically in the presence of oxygen appeared to offer great promise in that phenols could be oxidized all the way to para-quinones with little, if any, accompanying ort/to-oxidation (Scheme 10).27 Initial studies on model system 19 indicated that while 10% Co(salen) in THF gave a low 19% yield of... 

Molecules A and B were synthesized in order to compare their eventual activity against cerebral dysfunction, namely, memory disruption, with that of reference compound piracetam. Tested on mice, pyrrolizidine (A) delays this dysfunction better than piracetam (27.8% versus 21.7%). The ethylenediamine derivative (B) behaves similarly.501... 

Two complexing agents that form stable complexes with alkali metal ions. The ethylenediamine derivative (left) contains eight potential bonding atoms and the crown ether (right) contains... 

Methotrexate" 134 80 pCi/pg Ethylenediamine derivative of methotrexate reacted with B-H reagent and used in magnetoimmunoassay iodinated tyramine derivative gave better results... 

When 1,3-propanediamine semiclathrochelates have been used instead of ethylenediamine derivatives, the encapsulation of large metal ions in low oxidation states predominated. For instance, the rhodium(III) sarcophaginate was obtained by template condensation of the corresponding semiclathrochelate with formaldehyde and nitromethane in a high yield [5j ... 

Systemic contact dermatitis is a delayed hypersensitivity skin reaction that results from systemic exposure. Exanthematous systemic contact dermatitis from ethylenediamine has been reported with aminophylline. Disodium edetate (ethylenediamine tetra-acetic acid) has caused contact dermatitis after local application (SEDA-23, 242), and ethylenediamine cross-reacted in a patch test in a patient who had had contact dermatitis with hydroxyzine, an ethylenediamine derivative (SEDA-22, 178). Prior sensitization can occur to ethylenediamine in creams and ointments (SED-14, 485). 

Mebhydrolin is an antihistamine, an ethylenediamine derivative, with antimuscarinic and sedative properties. 

It was observed that the ethylenediamine derivative (33a) and its metal complexes undergo hydrolysis in strongly acidic dmso-water 80 20 wt/wt media, induced by the highly basic character of the nitrogen atoms of the aliphatic diamine.126,127 However, solutions in neutral or basic conditions were found to be stable. In contrast, (33q) and (33r), derived from o-phenylenediamine and m-phenylenediamine respectively, do not hydrolyze at pH higher than 2.5.123 124 128 The greater difficulty in protonating aromatic diamines compared to aliphatic diamines is believed to be responsible for the stability of these SBs and their complexes in acidic dmso-water solution. 

Much research have been focused on compartmental SB macrocycles derived from 2,6-diformyl (diacetyl)phenols as head units (see Scheme 19). The coordination chemistry of the phenol-based compartmental ligands was reviewed.2 A series of symmetrical and less extensively asymmetrical macrocycles (having dissimilar lateral chains) have been prepared (Scheme 19). The variation of the lateral chains of the macrocycle gives ligands with different cavity size and flexibility. Thus, the N202 cavity of the ethylenediamine derivative (65a) can accommodate only the small Cu11 and Ni11 ions because it has little flexibility. The replacement of the dimethylene by a trimethylene... 

Ethylenediamine derivatives Pyrilamine maleate Tripelennamine hydrochloride Tripelennamine citrate Alkylamine derivatives... 

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