Delayed hypersensitivity,

Beryllium (Be) Lung, hypersensitivity, delayed and progressive effects (berylliosis), contact dermatitis Nuclear power plants, alloy in metals, coal combustion... 

See also Cholinesterase Inhibition Hypersensitivity, Delayed Type. 

Hypersensitivity, Delayed Type, Pages 559-561, Leigh Ann Bums-Naas... 

HYPERSENSITIVITY, DELAYED DERMATITIS, CONTACT POISON IVY DERMATITIS HYPERSENSITIVITY, IMMEDIATE ANAPHYLAXIS ANGIONEUROTIC EDEMA ARTHUS PHENOMENON ASTHMA... 

ANIMAL EXPERIMENTS ANTIBODY FORMATION/DRUG EFF CYCLOPHOSPHAMIDE/THER USE ENGLISH ABSTRACT HYPERSENSITIVITY HYPERSENSITIVITY DELAYE/DRUG THY IMMUNIZATION IMMUNOSUPPRESSION IMMUNOSUPPRESSIVE AGENTS/THER USE MALE RATS SKIN TESTS TOXlNS/PHARMACO... 

Asthma is an extremely complex condition characterized by variable and reversible airways obstmction combiaed with nonspecific bronchial hypersensitivity (1 3). The cause of asthma, which is not always readily diagnosed (4), remains unknown. Days, if not weeks, ate needed to document the spontaneous reversal of the airways obstmction ia some patients. Asthmatics experience both an immediate hypersensitivity response and a delayed late-phase reaction, each mediated by a different pathway. Chronic asthma has come to be viewed as an inflammatory disease (5). The late-phase reaction plays a key role ia iaduciag and maintaining the inflammatory state which ia turn is thought to iaduce the bronchial hyperresponsiveness (6). The airways obstmction results from both contraction of airways smooth muscle and excessive bronchial edema. Edema, a characteristic of inflammatory states, is accompanied, ia this case, by the formation of a viscous mucus which can completely block the small airways. 

Chelated complexes such as sodium zirconium lactate [15529-67-6] or ammonium zirconium carbonate [22829-17-0] and acidic forms such as zirconium hydroxy oxide chloride [18428-88-1] have been used in preparations in deodorants or for treatment for poison oak and poison ivy dermatitis. In such occasions, when the skin had been cut or abraded, a few users developed granulomas which have been identified as a delayed hypersensitivity to zirconium (99). These may take several weeks to develop, and commonly persist for 6 months to over a year. 

Oral corrosion of metallic restorations does not, per se, generally result in serious damage to the structure. Corrosion can result, however, in various local and systemic effects, notably the hypersensitivity and allergic reactions reported by many workers. Galvanic cells created by mixed metal couples can delay fracture healing and induce oral lesions and cancer. 

Type IVb Reactions Delayed Type Hypersensitivity Reactions... 

Ross, P.S., de Swart, R.L., and Reijnders, P.J.H. et al. (1995). Contaminant related suppression of delayed type hypersensitivity and antibody responses in harbor seals from the Baltic Sea. Environmental Health Perspectives 103, 162. 

Not all symptoms after RCM exposure do resemble a hypersensitivity reaction. Toxic reactions related to the toxicity of RCM, imspecific reactions of unknown origin and or factors unrelated to RCM, such as chronic idiopathic urticaria, may occur (fig. 1) [3]. Hypersensitivity reactions to RCM may both present either under the clinical picture of anaphylaxis with the potential to result in fataUties or as delayed occurring... 

Romano A, Artesani M. Andriolo M. et al Effective prophylactic protocol in delayed hypersensitivity to contrast media report of a case involving lymphocyte transformation studies with different compounds. Radiology 2002 225 466-470. 

Beeler A, Zaccaria L, Kawabata T, et al CD69 upregulation on T cells as an in vitro marker for delayed-type drug hypersensitivity. Allergy 2008 63 181-188. 

Pichler WJ Delayed drug hypersensitivity reactions. Ann Intern Med 2003 139 683-693. 

Courvoisier S. Bircher AJ Delayed-type hypersensitivity to a nonionic, radiopaque contrast medium. Allergy 1998 53 1221-1224. 

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