Contact system

Counter-current rinsing and rinse-water reuse are useful tips for reducing usage. Counter-current contact systems are more efficient in promoting heat and mass exchanges, which are important to gas absorption, extraction, and many types of chemical reactions. 

Contactor design is important in order to maximize the ozone-transfer efficiency and to minimize the net cost for treatment. The three major obstacles to efficient ozone utilization are ozone s relatively low solubility in water, the low concentrations and amounts of ozone produced from ozone generators, and the instability of ozone. Several contacting devices are currently in use including positive-pressure injectors, diffusers, and venturi units. Specific contact systems must be designed for each different application of ozone to wastewater. Further development in this area of gas-liquid contacting needs to be done despite its importance in waste treatment applications. In order to define the appropriate contactor, the following should be specified ... 

In rare cases of a systemic release, kinins have the potential to cause severe hypotension. Uncontrolled activation of the contact system (Fig. 3) is thought to trigger a massive formation of kinins under certain pathological conditions [3]. For instance, this situation is seen in patients with underlying diseases such as systemic inflammatory response syndrome (SIRS) due to sepsis or trauma. SIRS progression is accompanied by depletion of contact system factors and low levels of H-kininogen and plasma kallikrein are indicative of a... 

Colman RW, Schmaier AH (1997) Contact system a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes. Blood 90 3819-3843... 

The model in its present form cannot be used for the design of gas-liquid contacting systems, for several reasons. The model requires a knowledge of the average bubble velocity relative to the fluid, U, a variable that is not available in most cases. This model only permits the calculation of the average rate per unit of area, and unless data are available from other sources on the total surface area available in the vessel, the model by itself does not permit the calculation of the overall absorption rate. 

These are often vertically mounted cylindrical tanks, up to 10 m in diameter, which typically are filled to a depth equal to about one diameter, although in some gas-liquid contacting systems tall vessels are used and the liquid depth is up to about three tank diameters multiple impellers fitted on a single shaft are then frequently used. The base of the tanks may be flat, dished, or conical, or specially contoured, depending upon factors such as ease of emptying, or the need to suspend solids, etc., and so on. 

Kaplan A, Silverberg M Contact system and its dis- 8 orders in Handin R, Lux S, Stossel T (eds) Blood -Principles Practice of Hematology. Philadelphia, 9 Lippincott Williams Wilkins, 1995, pp 1131-1155. 

Zahedi R. Wisnieski J, Davis AE 3rd Role of the P2 residue of complement-1 inhibitor (Ala443) in determination of target protease specificity inhibi- 93 tion of complement and contact system proteases. J Immunol 1997 159 983-988. 

Gas-liquid contacting systems can be modelled in a manner similar to liquid-liquid contactors. There are however some modelling features which are peculiar to gas-liquid systems. The single well-mixed contacting stage is shown in Fig 3.56. 

At present, the activation of the extrinsic coagulation system is considered to be of more importance in the initiation of DIC than the activation of the contact system (LI2, Cl 3). The activation of the extrinsic system starts with the release of tissue factor (TF) from endothelial cells. TF is a macromolecule, composed of a protein and a lipid fraction, that is synthesized by endothelial cells and monocytes. TF... 

Bacterial products such as lipopolysaccharides (endotoxins) and cytokines (IL-2) are able to activate the contact system in vitro and in vivo (D9, H4, H7, M41). Immediately after severe trauma or after surgical intervention and particularly during sepsis, a reduction of plasma contact system proteins has been found (C10, K1, N9). Gel filtration studies of plasma demonstrated that plasma PK after activation becomes complexed with a2-M and Cl-Inh (W4). These complexes are rapidly eliminated from the circulation in vivo. In experimental studies in which pulmonary insufficiency was induced in dogs, a significant reduction of plasma kallikrein inhibitors was observed together with reduced HMK. Analysis of the relation be-... 

H7. Hack, C. E., Wagstaff, J., Strack Van Schijndel, R Eerenberg, A., Pinedo, H Thijs, L., and Nuijens, J., Studies on the contact system of coagulation during therapy with high doses of recombinant IL-2 Implications for septic shock. Thromb. Haemost. 65,497-503 (1991). 

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