Polyarthritis chronic

Clinical use Oxyphenbutazone is a nonsteroidal antiinflammatory drug used for the acute treatment of ankylosing spondylitis, chronic polyarthritis and gout. 

Clinical use Phenylbutazone (Brogden, 1986) is a nonsteroidal anti-inflammatory drug used for the acute treatment of ankylosing spondylitis, chronic polyarthritis and gout. Phenylbutazone on its own shows only weak inhibition of COX-1 and COX-2 with IC50s >30 pM (Brideau et al., 1996) and active metabolites are mainly responsible for its actions. 

Differential diagnosis Palmar erythema is also found in pregnancy, in hyperthyroidism, collagen diseases, endocarditis, long-standing feverish conditions, tuberculosis, diabetes mellitus, malignant tumours, chronic polyarthritis and in cases of malnutrition — as well as in healthy people. 

Mayr N, Graninger W, Wessely P. Polyneuropathie bei chronischer Polyarthritis unter d-Penicillamin medika-mentos induziert [A chemically induced polyneuropathy in chronic polyarthritis treated with D-penicillamine ] Wien Klin Wochenschr 1983 95(3) 86-8. 

In contradistinction to the various types of chemically-induced and anaphylactic arthritis which have been mentioned above, adjuvant arthritis appears to simulate closely the inflammatory reactions seen in rheumatoid arthritis in humans. Stoerk, Bielinski and Budzilovitch first reported the development of a chronic polyarthritis in rats, and this work was later elaborated by a number of other workers " . The reaction seems to be a type of delayed hypersensitivity response , although recent work suggests that this may not be so. ... 

A. Acute and chronic polyarthritis and other synovial diseases... 

Additional reports of the efficacy of penicillamine in RA have appeared. " The parenteral use of gold was judged efficacious and safe for chronic polyarthritis when used with frequent laboratory checks. Retikinonase a neutral proteinase, and chymostatln, a chymotrypsin... 

Application of trace metal therapy using the influence of trace metals on biochemical processes or reactions, e.g., stimulation of the immune system (Zn, Se, Ge), treatment of chronic polyarthritis (Au), activity against free oxygen radicals (Se, possibly Mn), as well as treatment of manic-depressive diseases (Li) and gastrointestinal infections or gastric ulcer (Bi) [48,61,63]. 

Miscellaneous - Specific amino acids have been studied for anti-inflammatory activity. Thus, the combination of calcium D,L-aspartate/indometha-cin has been repor gd to be effective in primary chronic polyarthritis Dilauroyl-L-lyslne and trans U-aminomethyl-cyclohexane-l-carboxylic acid (tranexamic acid) have anti-inflammatory properties. The activity of tranexamic acid was not attributed to anti-plasmin action. Detailed pharmacology on SKF 17,910-A (X) has been published. This anti-inflammatory and diuretic agent shares some biological properties with glucocorticoids. 

Several small uncontrolled pilot studies have indicated that most patients with psoriatic arthritis improve when treated with etretinate at 0.5-1 mg/kg/day (Brackertz and Muller, 1979 Rosenthal 1979 Stollenwerk et al., 1981 Kaplan etal., 1983). In one report the etretinate-induced improvement allowed patients to decrease or discontinue their use of nonsteroidal anti-inflammatory agents. In another report patients with chronic polyarthritis similarly improved. RePUVA also led to improvement in five of six patients with psoriatic arthritis. However, because healing of cutaneous lesions of psoriasis with PUVA is associated with an improvement in joint disease, controlled studies are needed to confirm that etretinate is effective in psoriatic arthritis and that the effect is not secondary to cutaneous improvement. 

There is a long-standing hypothesis that the microvasculature plays a pathological role in forms of chronic inflammatory polyarthritis, particularly RA (Rothschild and Masi, 1982). One of the proposed mechanisms of vascular damage in connective tissue disease is the direct action of a cytotoxic serum factor inducing endothelial cell damage. Blake et al. (1985) have su ested that the vascular abnormalities associated with RA may be linked to oxidized lipoproteins because they are cytotoxic to endothelial cells. 

Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory joint disease. It is a progressive symmetrical, destructive and deforming polyarthritis affecting proxi-... 

Two commonly used models to detect anti-inflammatory activity are carrageenan-induced paw edema and adjuvant-induced polyarthritis in rats. The former represents an acute and the latter a chronic inflammatory process. Non-steroidal anti-inflammatory agents inhibit the formation of carrageenan-induced paw edema. However, to detect activity in the developing and established phases of chronic inflammation, the polyarthritis model is well accepted. In both tests the measured endpoint is volume of the hind paw. This is done by immersing the hind paw in the well of a mercury displacement... 

Juvenile chronic polyarthropathy (62) and reactive arthritis (63) have been attributed to hepatitis B vaccine. Erythema nodosum and polyarthritis occurred the day after Engerix-B vaccine administration (64). The authors referred to reports of three other cases of polyarthritis in the literature. 

There was an unexpectedly high incidence of rheumatoid and lupus-like symptoms (27 of 137 patients), namely arthralgia, arthritis, myalgia, and Raynaud s phenomenon, in patients with myeloproliferative disorders taking interferon alfa alone or combined with interferon gamma (365). However, only a minority of affected patients fulfilled the diagnostic criteria for systemic lupus erythematosus. By contrast, systemic autoimmune diseases appeared to be genuine but very rare complications of interferon alfa in chronic hepatitis C, with only one case of lupus-like syndrome and two cases of polyarthritis in a survey of 677 patients (18). 

Tausch G, BroU H, Eberl R. D-PeniciUamin (Artamin) als Basistherapie bei chronischer Polyarthritis. [D-penicUlamine (Artamin) as basic therapeutic agent in the treatment of chronic rheumatoid arthritis.] Wien Khn Wochenschr 1973 85(4) 59-63. 

Psoriatic arthritis occurs in approximately 15% of patients with psoriasis. The cause is unknown. Skin lesions are minimal with a polyarthritis affecting particularly the small joints of the hand in an asymmetrical pattern. Usually the disease is mild but chronic. Sometimes the joint involvement is similar to that seen in rheumatoid arthritis, that is, symmetrical polyarthritis. Rarely, the disease is rapidly progressing with joint destruction. The serum is rheumatoid factor negative. 

Mr Lewis is 68 years old. He has a chronic rheumatoid disease called Wegener s granulomatosis. In this condition, there is polyarthritis and vasculitis of small and medium sized blood vessels throughout the body. Mr Lewis also has type 2 diabetes. 

Traditional use A decoction of the root and fresh juice from the leaves are used to treat diarrhea. Juice from the petioles is recommended as a treatment for malaria (Khalmatov 1964). The young petioles and stems, and the fresh juice or compote made from them are used as a tonic, antipyretic and hypotensive to prevent anemia and to detoxify. The plant is used to increase the appetite and to treat gastritis with low acidity, Uver (hepatitis) and gallbladder diseases, tuberculosis, hemorrhoids, chronic constipation, polyarthritis, and fevers (Nuraliev 1989). 

Rheumatoid arthritis (RA) is the commonest inflammatoiy and destructive arthropathy in the world with a prevalence of 1000 per 100000. It is characterized by a chronic symmetrical polyarthritis that leads to joint damage in most patients. The commonest affeaed joints are the small joints of the hands and feet but it can involve any synovial joint. Rheumatoid fector is present in over 70% of the patients. The long-term prognosis of RA is poor as most patients develop significant disability despite treatment (1). Hence it is a major sodo-economical burden. In the UK, the cost of RA was estimated at 1.3 billion/year in 1992 (2). 

The 6-sulfanilamido-indazole (6-Sl)-induced polyarthritis in old rats is receiving increased attention as a chronic test model The zinc test in chickens is also being widely investigated. Although the pathogenesis of the syndrome associated with the spontaneous disease in Hew Zealand... 

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