Adjuvant induced polyarthritis

Two commonly used models to detect anti-inflammatory activity are carrageenan-induced paw edema and adjuvant-induced polyarthritis in rats. The former represents an acute and the latter a chronic inflammatory process. Non-steroidal anti-inflammatory agents inhibit the formation of carrageenan-induced paw edema. However, to detect activity in the developing and established phases of chronic inflammation, the polyarthritis model is well accepted. In both tests the measured endpoint is volume of the hind paw. This is done by immersing the hind paw in the well of a mercury displacement... 

Under suitable experimental conditions all major non-steroidal antiinflammatory drugs inhibit multiplication of different viruses in cell cultures. The synthetic polyanionic pyran copolymer has been found to induce interferon and to inhibit adjuvant-induced arthritis in rats. These data suggest that a virus may be Implicated in the pathogenesis of adjuvant-induced polyarthritis. 

In contradistinction to the various types of chemically-induced and anaphylactic arthritis which have been mentioned above, adjuvant arthritis appears to simulate closely the inflammatory reactions seen in rheumatoid arthritis in humans. Stoerk, Bielinski and Budzilovitch first reported the development of a chronic polyarthritis in rats, and this work was later elaborated by a number of other workers " . The reaction seems to be a type of delayed hypersensitivity response , although recent work suggests that this may not be so. ... 

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