Polyarthritis

Lipid abnormalities are associated with a wide spectrum of pathological conditions. In particular, recent advances have been made in understanding the role of lipoproteins in coronary heart disease (Davies and Woolf, 1993). However, included within the spectrum of diseases associated with perturbations of lipid metabolism are a number of musculoskeletal problems including inflammatory polyarthritis, tenosynovitis, osteoporosis and bone cysts. 

There is a long-standing hypothesis that the microvasculature plays a pathological role in forms of chronic inflammatory polyarthritis, particularly RA (Rothschild and Masi, 1982). One of the proposed mechanisms of vascular damage in connective tissue disease is the direct action of a cytotoxic serum factor inducing endothelial cell damage. Blake et al. (1985) have su ested that the vascular abnormalities associated with RA may be linked to oxidized lipoproteins because they are cytotoxic to endothelial cells. 

CX3XLI SF ELISA Higher levels compared with OA, JRA, PA, polyarthritis, and gout. 178... 

Pattison D, Symmons D, Lunt M, Welch A, Birngham S, Day N and Silman A. 2005. Dietary (3-cryptoxanthin and inflammatory polyarthritis results from population-based prospective study. Am J Chn Nutr 82 451 155. 

Suggested Alternatives for Differential Diagnosis Foot-and-mouth disease, vesicular stomatitis, peste des petits ruminants, photosensitisation, nasal botfly infestation, pneumonia, akabane infection, epizootic hemorrhagic disease of deer, contagious ecthyma, polyarthritis, footrot, foot abscesses, plant poisonings, and coenurosis. 

Creamer et al. (1994) reported cases of breast cancer where the use of tamoxifen was temporally related to the development of an inflammatory polyarthritis resembling rheumatoid arthritis. Cases of cyclical psoriatic arthritis, however, have positively responded to antiestrogen therapy (Stevens et al. 1993). Tsai and Liu (1992) have shown that tamoxifen concurrently injected with estradiol benzoate antagonizes the condrodestructive effects of estradiol at the early stage of knee osteoarthritis in rabbits. 

Creamer P, Lim K, George E, Dieppe P (1994) Acute inflammatory polyarthritis in association with tamoxifen. Br J Rheumatol 33 998... 

K3. Kluthe, R., and Muller, W., Veranderungen der ctj-Globulin-Unterfraktionen bei chronischer Polyarthritis. Congr. Lega Intern, contro il Reumatismo. Roma 2, 185 (1961). 

Indomethacin is used in rheumatoid arthritis, nonspecific infectious polyarthritis, gouty arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, neuralgia, myalgia, and other diseases accompanied by inflammation. Synonyms for indomethacin are, among others, metindol, indacide, and rumacide. 

Prednisolone is used for the same indications as aU corticosteroids rheumatism, polyarthritis, bronchial asthma, neurodermatitis, and eczema. Synonyms of this drug are anti-solon, decortin, cortolon, precortilon, and many others. 

Serum sickness-like reactions (erythema multiforme or skin rashes accompanied by polyarthritis, arthralgia and, frequently, fever) have been reported these reactions usually occurred following a second course of therapy. Signs and symptoms occur after a few days of therapy and resolve a few days after drug discontinuation with no serious sequelae. 

Viral arthritis is rather common and usually selflimited within a few weeks. The most common pathophysiological mechanism is not a direct virus invasion in the synovium but deposition of immune complexes. Viral infections frequently involve multiple joints and produce inflammation without suppuration. The typical clinical presentation is a peripheral and symmetrical polyarthritis, undistin-guishable from other inflammatory arthritis. Virtually all viruses can cause arthritis. There is no specific treatment and simple symptomatic measures are sufficient. 

Fluorination of corticosteroids at C-9 or/and C-6 increases glucocorticoid activity, while mineralocorticoid activity, responsible for sodium retention (the main adverse effect of corticoids), is decreased (cf. Chapter 4). Fluorocorticoster-oids were the first fluorinated compounds to be used clinically. They are still major drugs against many inflammatory disorders rheumatoid polyarthritis, ORL (asthma, rhinitis), brain edema, dermatological, allergies, anaphylactic shock, Quincke s edema). 

Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory joint disease. It is a progressive symmetrical, destructive and deforming polyarthritis affecting proxi-... 

Lincomycin is reported to cause gastrointestinal disturbances including diarrhea, vomiting, nausea, and colitis that may prove fatal. Other adverse effects include skin rashes, urticaria, polyarthritis, hepatic damage, and hematological disturbances. 

Clinical use Oxyphenbutazone is a nonsteroidal antiinflammatory drug used for the acute treatment of ankylosing spondylitis, chronic polyarthritis and gout. 

Clinical use Phenylbutazone (Brogden, 1986) is a nonsteroidal anti-inflammatory drug used for the acute treatment of ankylosing spondylitis, chronic polyarthritis and gout. Phenylbutazone on its own shows only weak inhibition of COX-1 and COX-2 with IC50s >30 pM (Brideau et al., 1996) and active metabolites are mainly responsible for its actions. 

Braz, J., Beaufour, C., Coutaux, A., Epstein, A.L., Cesselin, F., Hamon, M., Pohl, M. Therapeutic efficacy in experimental polyarthritis of viral-driven enkephalin overproduction in sensory neurons, J. Neurosci. 2001, 21, 7881-7888. 

An acute inflammatory polyarthritis resembling rheumatoid arthritis has been reported in three women temporally related to the use of tamoxifen (89). 

Vasculitis, Raynaud s phenomenon, and polyarthritis have been reported with gemfibrozil (65). 

Smith GW, Hurst NP. Vasculitis, Raynaud s phenomenon and polyarthritis associated with gemfibrozil therapy. Br J Rheumatol 1993 32(l) 84-5. 

Delrieu F, Menkes Cl, Sainte-Croix A, Babinet P, Chesneau AM, Delbarre F. Myasthenie et thyroidite auto-immune au course du traitements de la polyarthrite rhumato ide par la D-penicillamine. Etude anatomo-clini-que d un cas. [Myasthenia gravis and autoimmune thyroiditis during the treatment of rheumatoid polyarthritis with D-penicillamine. Anatomoclinical study of 1 case.] Ann Med Interne (Paris) 1976 127(10) 739-43. 

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