Non steroidal anti-inflammatory agents

Non-steroidal anti-inflammatory agents, aspirin, and acetaminophen have been suggested for use in the prevention of different cancers, especially hereditary non-polyposis colon cancer.14 While there have been observational studies linked to a reduction of ovarian carcinoma risk, evidence is still lacking. Potential... 

Evaluate patient comorbidities and medications to determine if additional work-up is necessary prior to tumor debulking surgery. Do any medications need to be stopped or changed prior to surgery (e.g., aspirin, warfarin, or non-steroidal anti-inflammatory agents) ... 

Among recent examples that highlight the synthetic utility of transition metal-catalyzed hydroborations are its direction toward a formal syntheses of the non-steroidal anti-inflammatory agents Ibuprofen 131 and Naproxen 13214 15 139 as well as the anti-depressant Sertraline 133 (Figure 14).140 In the majority of cases, rhodium-catalyzed hydroboration is utilized and the rhodium(i) source generally is Wilkinson s catalyst RhCl(PPh3)3. 

Electrochemistry offers new routes to the production of several commercially relevant a-arylpropionic acids, used as non-steroidal anti-inflammatory agents (NSAI) [178,182]. A preparative method based on sacrificial Al-electrodes has been set up for the electrocarboxylation of ketones [117,183-187] and successfully applied to the electrocarboxylation of aldehydes, which failed with conventional systems. The electrocarboxylation of 6-methoxy-acetonaphthone to 2-hydroxy-2-(6-methoxynaphthyl)propionic acid, followed by chemical hydrogenation to 2-(6-methoxynaphthyl)-2-propionic acid - one of the most active NSAI acids - has been developed up to the pilot stage [184,186],... 

Khawaja, A.M., Liu, Y.C., and Rogers, D.F., Effect of fenspiride, a non-steroidal anti-inflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro, Pulm. Pharmacol. Then, 12, 363-368, 1999. 

Naproxen is a non-steroidal anti-inflammatory agent classified as a propionic acid derivative. 

Many interactions with lithium have been described. Thiazide and loop diuretics decrease lithium excretion predisposing to serious lithium toxicity. Also non-steroidal anti-inflammatory agents, especially indomethacin can increase the risks for lithium toxicity due to decreased renal excretion. 

Acetyl salicylic acid and related non-steroidal anti-inflammatory agents can cause severe asthma... 

R. Nickander, E. G. McMahon, A. S. Ridollo (1979). Non-steroidal anti-inflammatory agents Annu. Rev. Pharmacol. Toxicol. 19 649-690. 

Cleavage at the benzylic position has likewise been observed in a variety of (hetero) aromatic derivatives such as chloramphenicol (Sch. 13) (31) or methotrexate (32). An important case is that of the decarboxylation of arylacetic or arylpropionic acids used as non-steroidal anti-inflammatory agents (Sch. 14) (33-35). 

Indomethacin is a non-steroidal, anti-inflammatory agent with anti-pyretic and analgesic properties discovered and developed by the Merck Sharp and Dohme Research Laboratories(1). 

N.K. Jagota and J.T. Stewart, Separation of non-steroidal anti-inflammatory agents using supercritical fluid chromatography, J. Chromatogr., 604 255 (1992). 

C. Sarbu, Detection of some non-steroidal anti-inflammatory agents by thin-layer chromatographic plates coated with fluorescent mixtures, J. Chromatogr., 367 286 (1986). 

Experimental and clinical observations indicate that non-steroidal anti-inflammatory agents (NSAIDs, see p. 403) such as aspirin and indomethacin are effective in controlling diarrhea. This antidiarrheal action is probably due to inhibition of prostaglandin synthesis. Bismuth subsalicylate (pepto-bismol), used for traveler s diarrhea, decreases fluid secretion in the bowel its action may be due to its salicylate component. 

Non-Steroidal Anti-Inflammatory Agents (NASID), like indomethacin and acetyl-salicylic acid (aspirin), induce gastric lesions in man and in experimental animals by inhibition of gastric cyclooxygenase (COX) resulting in less formation of prostacyclin, the predominant prostanoid produced in the gastric mucosa. 

Q9 Some women s symptoms are helped by non-steroidal anti-inflammatory agents such as ibuprofen, and in some women a combined oral contraceptive... 

Danion JM, Schmidt M, Welsch M, Imbs JL, Singer L. Interaction entre les anti-inflammatoires non steroidiens et les sels de lithium. [Interaction between non-steroidal anti-inflammatory agents and lithium salts.] Encephale 1987 13(4) 255-60. 

The profens are non-steroidal anti-inflammatory agents based on arylpropionic acids the best known is ibuprofen. The BHC company (Boots-Hoechst-Celanese) developed a commercial route to ibuprofen which involves a... 

Henry D, Lim LL, Garcia-Rodriguez LA, et al. (1996) Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory agents - results of a collaborative meta-analysis. Br Med J 312 1563-1566. 

Non-steroidal anti-inflammatory agents, including ibuprofen and selective Cox-2 inhibitors (cyclo-oxygenase 2), can increase plasma lithium concentrations add with caution to patients stabilized on lithium... 

Thiazolyl and benzothiazolyl derivatives are known for their anti-inflammatory, analgesic, and antipyretic activities [72-77], for example Meloxicam (Fig. 3) is a known non-steroidal anti-inflammatory agent with a thiazolyl... 

Srimal, R.C., and Dhawan, B.N., Pharmacology of diferuloylmethane (curcumin), a non-steroidal anti-inflammatory agent, J. Pharm. Pharmacol, 25, 447, 1973. Satoskar, R.R., Shah, S.J., and Shenoy, S.G., Evaluation of antiinflammatory property of curcumin (diferuloylmethane) in patients with postoperative inflammation, Int. J. Clin. Pharmacol Then Toxicol, 24, 651, 1986. 

Sivaprasad S, Bunce C, Patel N. Non-steroidal anti-inflammatory agents for treating cystoid macular oedema following cataract surgery. Cochrane Database of Systematic Reviews 2004, Issue 3.Art. No. CD004239. 

Swaisland et al. reported a comparison of silica and reversed-phase material of non-steroidal anti-inflammatory agents 1137). 

---