Lymph node metastasis cancer

Formation of regional lymph node metastasis can be an important step in dissemination of cancer cells. In colorectal cancer, lymph node metastasis frequently occurs in patients (7, 8) and is an important factor in staging the disease. In particular, the metastatic lymph node ratio (LNR number of metastatic lymph nodes/number of examined lymph nodes) is predictive of overall survival (OS) and disease-free survival (DFS) in colorectal cancer patients (9, 10). Hence, an animal model of colorectal cancer with measurable lymphatic metastasis that allows for rapid evaluation of the effects of candidate treatment regimens on primary tumor growth and lymph node metastasis would be of great value. [Pg.236]

Kato M, Kitayama J, Kazama S, Nagawa H. Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma. Breast Cancer Res 2003 5 144-150. [Pg.345]

Ding Y, Shimada Y, Maeda M, et al. Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin Cancer Res 2003 9 3406-3412. [Pg.347]

Mashino K, Sadanaga N, Yamaguchi H, et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res 2002 62 2937-2941. [Pg.347]

Takanami, I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer correlation with lymph node metastasis. Int J Cancer 2003 105 186-189. [Pg.347]

Wiley HE, Gonzalez EB, Maki W, Wu M-T, Hwang ST. Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. J Nat Cancer Inst 2001 93 1638-1643. [Pg.347]

Roder JD, Bottcher K, Busch R, Wittekind C, Hermanek P, Siewert JR. Classification of regional lymph node metastasis from gastric carcinoma. German Gastric Cancer Study Group. Cancer 1998 82(4) 621-631. [Pg.233]

K. Yutani, E. Shiba, H. Kusuoka, M. Tatsumi, T. Uehara, T. Taguchi, S.l. Takai, T. Nishimura, Comparison of FDG-PET with MIBI-SPECT in the detection of breast cancer and axillary lymph node metastasis, J. Comput. Assist. Tomogr. 24(2) (2000) 274-280. [Pg.185]

T. Hara, K. Inagaki, N. Kosaka, T. Morita, Sensitive detection of mediastinal lymph node metastasis of lung cancer with IlC-choline PET, J. Nucl. Med. 41(9) (2000) 1507-1513. [Pg.193]

Ichiki K, Mitani N, Doki Y, Hara H, Misaki T, Saiki I. 2000. Regulation of activator protein-1 activity in the mediastinal lymph node metastasis of lung cancer. Clin Exp Metastasis 18 539-545. [Pg.390]

We have developed a firefly luciferase-expressing HT-29 colorectal cancer cell line, HT-29LP, to realize the benefits of BLI with an orthotopic colorectal cancer model. Primary tumors were established by implantation of HT-29LP cells into the submucosal layer of the rectum of mice, and tumor growth and lymph node metastasis were evaluated. A positive control treatment... [Pg.236]

Tsutsumi S., Kuwano H., Morinaga N., Shimura T., Aso T. (2001) Animal model of para-aortic lymph node metastasis. Cancer Lett 169, 77-85. [Pg.252]

Kikuchi T, Daigo Y, Katagiri T, Tsunoda T, Okada K, Kakiuchi S, Zembutsu H, Furukawa Y, Kawamura M, Kobayashi K, Imai K, Nakamura Y, Expression profiles of nonsmall cell lung cancers on cDNA microarrays Identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs, Oncogene, 22 2192-2205, 2003. [Pg.565]

Uchida, S., Shimada, Y, Watanabe, G., Li, Z. G., Hong, T., Miyake, M. and Imamura, M. (1999). Motility-related protein (MRP-1/CD9). and KAI1/CD82 expression inversely correlate with lymph node metastasis in oesophageal squamous cell carcinoma. Br. J. Cancer 79, 1168-1173. [Pg.339]

MMPs also act as predictors of recurrence or metastatic risk. High preoperative serum levels of MMP-2 or MMP-3 are predictive of recurrence in patients with advanced urotheliai carcinoma. Furthermore, high levels of MMP-2 in ovarian tumor cells can predict tumor recurrence. The expression of certain MMPs is predictive of metastatic risk. For example, expression of MMP-1 is associated with lymph node metastasis in cervical and peritoneal metastasis in gastric cancer. MMP inhibition may be a therapeutic strategy for cancer. ... [Pg.763]

Hatakeyama, K. et al. (2004) Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma. Cancer Letters, 212 (2), 253-259. [Pg.273]

Overexpression of Ll-cadherin in gastric cancer is associated with lymph node metastasis. Biochemical and Biophysical Research Communications,... [Pg.273]

Sulzer MA, Leers MP, van Noord JA, et al. Reduced E-cadherin expression is associated with increased lymph node metastasis and unfavorable prognosis in non-small cell lung cancer. Am J Res Crit Care Med 1998 157 1319-1323. [Pg.2379]

Radiographic imaging studies evaluate the extent of disease involvement. A chest x-ray should be performed to rule out the presence of metastatic spread to the lungs. A CT scan of the abdomen and pelvis is often performed to evaluate hepatic and retroperitoneal involvement and occult abdominal and pelvic disease, and to determine the depth of tumor penetration into the bowel wall and/or invasion to adjacent organs. Detection of lymph node involvement with either smdy is limited by the difficulty of distinguishing inflammatory or reactive lymph nodes from those infiltrated with tumor. Because CT scans may not adequately detect peritoneal seeding, small distant lymph node metastasis, or liver metastasis in colon cancer, an occasional patient may... [Pg.2394]

Cheng L, Pisansky TM, Sebo TJ, et al. Cell proliferation in prostate cancer patients with lymph node metastasis a marker for progression. Clin Cancer Res. 1999 5 2820. [Pg.654]

Kodama J., Flasengaowa, Kusumoto T., et al. (2007) Association of CXCR4 and CCR7 chemokine receptor expression and lymph node metastasis in human cervical cancer. Ann Oncol., 18, 70-6. [Pg.44]

Zhang J. P., LuW. G., Ye F., et al. (2007) Study on CXCR4/SDF-1 alpha axis in lymph node metastasis of cervical squamous cell carcinoma. Ini J Gynecol Cancer., 17, 478-83. [Pg.44]

Fukunaga S, Maeda K, Noda E, et al. (2006) Association between expression of vascular endothelial growth factor C, chemokine receptor CXCR4 and lymph node metastasis in colorectal cancer. Oncology 71 204-211... [Pg.57]

Woo S, Bae J, Kim C, et al. (2007) A significant correlation between nuclear CXCR4 expression and axillary lymph node metastasis in hormonal receptor negative breast cancer. Ann Surg Oncol 15 281-285... [Pg.62]

Yang YC, Lee ZY, Wu CC, et al. (2007b) CXCR4 expression is associated with pelvic lymph node metastasis in cervical adenocarcinoma. Int J Gynecol Cancer 17 676 686... [Pg.62]

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