Invasive ductal carcinomas

Kato M, Kitayama J, Kazama S, Nagawa H. Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma. Breast Cancer Res 2003 5 144-150. 

MacGrogan G, Soubeyran I, De Mascarel I, et al. Immunohistochemical detection of progesterone receptors in breast invasive ductal carcinomas. Appl. Immunohistochem. 1996 4 219-227. 

Tumor heterogeneity refers to the existence of distinct subpopulations of tumor cells with specific characteristics within a single neoplasm. Breast cancer is a classic example of a heterogeneous disease. First, the term breast cancer does not itself refer to a single disease. Breast cancers include many different diseases including (but not limited to) adenomas, papillomas, invasive ductal carcinoma, ductal carcinoma in situ (DCIS), and lobular carcinoma in situ (LCIS) (6). 

FIGURE 10.7. Immunostained p53 antigen in the moderately differentiated invasive ductal carcinoma of the pancreas of a 54-year-oid female the majority of the nuclei are stained. Sections were microwaved and incubated in mouse monoclonal antibody DO-1. Courtesy of Ming Dong. 

FIGURE 11.4. Immunostained estrogen receptor a in invasive ductal carcinoma of the breast, using microwave heat pretreatment and monoclonal antibody ERID5 specific for ERa (diluted 1 100). This antibody is superior to monoclonal antibody H222. Courtesy of King-Chung Lee. 

Lee, A. H. S., Dublin, E. A., Bobrow, L. G., and Poulsom, R. 1998. Invasive lobular and invasive ductal carcinoma of the breast show distinct patterns of vascular endothelial growth factor expression and angiogenesis. / Pathol. 785 394-401. 

A 62-year-old woman with invasive ductal carcinoma of the breast was treated with epirubicin and cyclophosphamide. She rapidly developed swelling and necrosis of the tongue and consequent airway obstruction necessitating tracheostomy. After excision of the necrosis, the swelling of the tongue and the airway obstruction resolved. 

Most interestingly, lOPNs, typically lack KRAS2 mutations ° 726 stark contrast with any other tumor types in the pancreas characterized by ductal-mucinous differentiation including greater than 90% of invasive ductal carcinomas and almost half of IPMNs. 

Saitou M, Goto M, Horinouchi M, et al. MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. / Clin Pathol. 2005 58 845-852. 

Based on cell cohesiveness, the two broad categories of breast carcinoma (invasive and in situ) are ductal and lobular types. Ductal carcinoma in situ increases the risk of invasive malignancy at the local site. Lobular carcinoma in situ is considered a marker of generalized increased risk of invasive malignancy, although some recent data suggest precursor properties for lobular carcinoma in situJ Invasive ductal carcinomas are often unifocal lesions compared to invasive lobular carcinomas, which are often multifocal or more extensive than... 

Borst MJ, Ingold JA. Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery. 1993 114 637-641 discussion 641-642. 

Mersin H, Yildirim E, Gulben K, et al. Is invasive lobular carcinoma different from invasive ductal carcinoma Eur J Surg Oncol. 2003 29 390-395. 

Frolik D, Caduff R, Varga Z. Pleomorphic lobular carcinoma of the breast Its cell kinetics, expression of oncogenes and tumour suppressor genes compared with invasive ductal carcinomas and classical infiltrating lobular carcinomas. Histopathology. 2001 39 503-513. 

FIGURE 21.21 Fine-needle aspiration biopsy of a breast mass. (A) Papanicolaou stain. (B) Diff-Quik smears of cytomorphologically invasive ductal carcinoma. (C) HER2/neu moderate complete strong membranous staining (score 2+) (FIP). At follow-up fluorescence in situ hybridization showed amplification. Such cytology specimens must be formalin fixed. 

Kalogeraki A, Garbagnati F, Santinami M, et al. E-cadherin expression on fine needle aspiration biopsies of breast invasive ductal carcinomas and its relationship to clinicopathologic factors. Acta Cytol. 2003 47 363-367. 

Studies show that overall about 30% of invasive ductal carcinomas manifest amplification of ErbB-2 (Lipponen et al., 1993 Slamon et al., 1987). No difference was seen in ErbB-2 expression between different ethnic groups in the United States (Elledge et al., 1994 Weiss et al., 1995). While DCIS of the comedo type more frequently shows higher expression than does invasive disease, tumors greater than 1 cm in size tend to show ErbB-2 overexpression more frequently than do smaller tumors (Schimmelpenning et al., 1992), and higher grade tumors more frequently overexpress than do lower... 

About 30% of unselected breast carcinomas are associated with HER-2 overexpression most of them are invasive ductal carcinoma, infiammatory breast cancer, Paget s disease as well as breast cancer arising in pregnant women, whereas invasive lobular carcinoma, mucinous carcinoma and medullary carcinoma of the breast are rarely accompanied by HER-2 overexpression. HER-2 overexpression is also found in a significant percentage of male breast carcinomas (about 30%). 

Tsutsui S, Kume M, Era S. Prognostic value of microvessel density in invasive ductal carcinoma of the breast. Breast Cancer 2003 10 312 319. 

At histopathological examination, the lesion with strong and early enhancement proved to be a ductal carcinoma in situ, whereas the lesion with gradual increasing enhancement proved to be an invasive ductal carcinoma (IDC)... 

Fig. 12.4. Small IDC detected with dual-energy CEDM examination. Mammograms show a small opacity in the upper quadrant of the breast best seen on mediolateral view (a) than on cranio-caudal view (b). Subtracted dual-energy CEDM MLO (c) and CC (d) images, acquired respectively 2 and 4min after injection of an iodinated contrast agent, readily depict a small enhancing nodule corresponding to a 6-mm invasive ductal carcinoma...

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