Therapeutic strategies

Es gibt nur eine Gesundheit end eine Menge von Krankheiten. 

Bioinorganic Photochemistry Grazyna Stochel, Malgorzata Brindell, Wojciech Macyk, Zofia Stasicka, Konrad Szacilowski 2009 Grazyna Stochel, Malgoizata Brindell, Wojciech Macyk, Zofia Stasicka, Konrad Szacilowski. ISBN 978-1-405-16172-5 

Biomedical photonics has the potential to revolutionize medicine as we know it, especially by application of nanotechnology and nanomaterials, leading to diagnostics and therapy at the molecular level. 

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By similar logic, protein affinity Hbraries have been constmcted to identify protein—protein combining sites, as in antibody—antigen interaction (19) and recombinant Hbraries have been made which produce a repertoire of antibodies in E. coli (20). In another case, a potential DNA-based therapeutic strategy has been studied (21). DNAs from a partially randomized Hbrary were selected to bind thrombin in vitro. Oligonucleotides, termed aptamers that bound thrombin shared a conserved sequence 14—17 nucleotides long. 

Angiogenesis and Vascular Morphogenesis. Table 2 Antiangiogenic therapeutic strategies (noncomprehensive list)... 

Ahima RS, Osei SY (2001) Molecular regulation of eating behavior new insights and prospects for therapeutic strategies. Trends Mol Med 7 205-213... 

Based on the role of endocannabinoids and cannabinoid receptors in several pathological conditions, the pharmacological manipulation of their levels or action is being developed as a therapeutic strategy. Enhancement of endocannabinoid signalling when this plays uniquely a protective role can be effected in a safer way using (i) cannabis extracts in which the presence of non-psychotropic cannabinoids with therapeutic activity per... 

In conclusion, the discovery of incretins has now come to an end in terms of therapeutic strategy of metabolic diseases since new medicines will be put on the market these coming years. However, a lot more needs to be done with regard to the physiological role of the hormones. Whereas the major filed of investigation for GLP-1 now relates to the effect of the peptide on the central nervous system and on (3-cell proliferation, for GIP it remains to understand its role in the numerous tissues where the corresponding receptor is expressed. 

Gene Therapeutic Strategies that Act via Host Immune Effector Mechanisms.283... 

To onr knowledge, all antiviral gene-therapeutic strategies tested in clinical trials to date target HIV-infection. 

HavUr DV, Richman DD (1996) Viral dynamics of HIV implications for drug development and therapeutic strategies. Ann Intern Med 124(11) 984—994 Hinrichsen H, Benhamou Y, Wedemeyer H, Reiser M, Sentjens RE, Calleja JL, Foms X, Erhardt A, Cronlein J, Chaves RL, Yong CL, Nehmiz G, Steinmann GG (2004) Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype I patients. Gastroenterology 127(5) 1347-1355... 

Harloff A, Handke M, Reinhard M, Geibel A, Hetzel A. Therapeutic strategies after examination by transesophageal echocardiography in 503 patients with ischemic stroke. Stroke 2006 37 859-864. 

Neurotransmitter receptors have evolved as one of the key components in the ability of the central nervous system to coordinate the behaviour of the whole animal, to process and respond to sensory input, and to adapt to change in the environment. These same receptors are therefore ideal targets for drug action because of their central role in the activity of the nervous system. A rational approach to the development of new therapeutic strategies involving the action of drugs at receptors in the nervous system is based on knowledge of receptor structure, distribution and function. 

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