Cervical Adenocarcinoma

In order to assess the effect of the corn cob xylan on the cell viability and proliferation rate, xylan solutions at concentrations of 0.1, 0.25, 0.50, 0.75, and 1 mg/ml were placed in contact with human cervical adenocarcinoma cells (HeLa cells) for 24 and 72 h. Finally, the cell viability was determined by the MTT assay. It was observed that regardless of the xylan concentration, the samples tested did not affect the viability of HeLa cells after incubation for 24 h (Figure 13) (Unpublished data). 

Preliminary evidence suggest that c-erbB-2 may also be a prognostic marker for other cancers such as gastric (Y2), ovarian (S7), cervical (K5), and nonsmall cell carcinoma of the lung (K3). Thus, c-erbB-2 has the potential to be a prognostic marker for many different types of adenocarcinomas. 

Gardasil is a noninfectious recombinant vaccine consisting of capsid proteins from four different human papillomaviruses (HPVs) of types 6,11, 16, and 18. HPV causes squamous cell cervical cancer and cervical adenocarcinoma, as well as 35-50% of vulvar and vaginal cancers. 

GardasU Four placebo-controUed, double-blind, randomized Phase II and Phase III trials were conducted to evaluate the efficacy. Cervical intraepithelial neoplasia (CIN) and adenocarcinoma in situ (AIS), vulvar intraepithelial neoplasia (VIN), and genital warts were used as the surrogate markers. 

Breast, ovarian, cervical, bladder and prostate cancer gastrointestinal adenocarcinomas Metastatic pancreatic cancer small cell lung cancer Leukemia Breast cancer... 

Tumor-promoting effect. A 28-year-old man who abused alcohol, nicotine, and cannabis for several years was investigated. He suffered simultaneously from a squamous cell carcinoma of the hypopharynx with bilateral cervical metastases, an adenocarcinoma of the transverse colon and a primary hepatocellular carcinoma. There were occurrences of three separate malignant tumors with different histologies in the aerodigestive tract, which could be related to a chronic abuse of cannabis . 

Lacey JV Jr et al Oral contraceptives as risk factors for cervical adenocarcinomas and squamous cell carcinomas. Cancer Epidemiol Biomarkers Prev 1999 8 1079. [PMID 10613340]... 

The cervical section presented in Fig. 10.7 has been diagnosed as a rare form of neoplasma known as villoglandular adenocarcinoma. Characteristic cytologic features of this condition include the presence of long villous fronds and papillae lined by columnar cells with intact cytoplasmic borders and minimal atypia.32 Three-dimensional ball-like clusters of cells with smooth intact communal cytoplasmic rings are also associated with this condition.32... 

Chiriboga, L., Diem, M. and Wood, B. R. (2003) Letter in response to infrared spectral features of exfoliated cervical cells, cervical adenocarcinoma tissue and adenocarcinoma cell line . Gynecol. Oncol. 91, 275-6. 

Originally isolated from cervical adenocarcinoma. cKeratin pattern is identical to that of normal hepatocytes. 

Houze (8) prepared pentafluorophenylsulfonanilide urea derivatives, (VIII), that were effective in arresting the growth of HeLa cells derived from a human cervical adenocarcinoma tumor cells. 

The antiproliferative and antitubulin activities of libraries of pyranopyridones and pyranoquinolones 147 (Scheme 28) derived from aldehydes, malononitrile and pyridones 146 have been examined [65]. The compounds were evaluated for their ability to reduce cell viability by 50% after 48 h of treatment relative to control. The HeLa and MCE-7 cell fines were used as models for human cervical and breast adenocarcinoma, respectively. Numerous compounds exhibited submicromolar antiproliferative activities with the quinolones being more potent than their pyridine counterparts (Eig. 20). Because of the structural similarity of pyranopyridones with chromene scaffolds known to inhibit tubulin polymerization, compounds 149 and 150 were further evaluated in Jurkat cells for their apoptotic... 

Clear cell adenocarcinoma (40 times more likely than unexposed women), a rare kind of vaginal and cervical cancer. 

Human cervical epithelial adenocarcinoma (HeLa) cells (ATCC). 

For adherent cell cultures, the following protocol for HeLa cells may serve as an example. Cervical adenocarcinoma (HeLa) cells (purchased from the American Tissue and Cell Culture Corp. ATCC Manhasset, VA, USA), cell line CCL-2, were seeded in 75 cm sterile plastic cell culture flasks (Fisher Scientific) at a concentration of approximately 2 X 10 cells cm l Typically, the growth medium consisted of 20ml Dulbecco s Modified Eagle s Medium (DMEM ATCC), supplemented with 10% fetal bovine serum (FBS ATCC). To prevent bacterial contamination, 2.5ggmT of amphotericin B (ATCC) and lOOIUmT penicillin/streptomycin (ATCC) was added to the medium. The cells were incubated at 37 °C in an atmosphere containing 5% COj. 

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