Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

L-buthionine-S,R-sulfoximine

As noted above, the X-ray sensitization of cells using MGd has been investigated extensively and appears to operate at least in part in an oxygen dependent manner, with cytotoxic activity that is substantially enhanced upon the addition of ascorbate to the media [69], The cytotoxic activity of MGd can also be enhanced with L-buthionine-S,R-sulfoximine (BSO), an irreversible inhibitor of an enzyme involved in glutathione biosynthesis (y-glutamylcysteine synthetase), that serves to suppress the synthesis of ROS-protective glutathione. Presumably, this activity is responsible for the in vitro radiation enhancing effect of BSO [66,71],... [Pg.413]

C8H18N203S L-buthionine-(S,R)-sulfoximine 83730-53-4 25.00 1.1249 2 15787 C9H4CI3IO 3-iodo-2-propynyl-2,4,5-trichlorophenyl ether 777-11-7 25.00 1.9350 2... [Pg.241]

Romero FJ, Sies FI (1984) Subcellular glutathione contents in isolated hepatocytes treated with L-buthionine sulfoximine. Biochem Biophys Res Commun 123 1116-1121 Romieu A, Gasparutto D, Cadet J (1999a) Synthesis and characterization of oligonucleotides containing 5, 8-cyclopurine 2 -deoxyribonucleosides (5 R)-5, 8-cyclo-2 -deoxyadenosine, (5 S)-5, 8-cyclo-2 -deoxyguanosine and (5 R)-5, 8-cyclo-2 -deoxyguanosine. Chem Res Toxicol 12 412-421... [Pg.473]

Sipos EP, Witham TF, Ratan R, Burger PC, Baraban J, Li KW, Piantadosi S, Brem H. L-buthionine sulfoximine potentiates the antitumor effect of 4-hydroperoxycyclophosphamide when administered locally in a rat glioma model. Neurosurgery 2001 48 392-400. [Pg.377]

See other pages where L-buthionine-S,R-sulfoximine is mentioned: [Pg.876]    [Pg.408]    [Pg.477]    [Pg.716]    [Pg.438]    [Pg.876]    [Pg.408]    [Pg.477]    [Pg.716]    [Pg.438]   
See also in sourсe #XX -- [ Pg.408 ]



SEARCH



Buthionine sulfoximine

L-buthionine sulfoximine

Sulfoximine

Sulfoximines

© 2024 chempedia.info